Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency

Detalhes bibliográficos
Autor(a) principal: Santos-Miranda, Artur
Data de Publicação: 2015
Outros Autores: Cruz, Jader Santos, Roman-Campos, Danilo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.5935/abc.20150010
http://repositorio.unifesp.br/handle/11600/38806
Resumo: In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. in order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells.
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spelling Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine DeficiencyPropriedades Elétricas de Cardiomiócitos Isolados em um Modelo Animal em Ratos com Deficiência de TiaminaMyocytes, CardiacElectric StimulationThiamine Deficiency/physiopathologyAction PotentialsRats, Heart FailureIn modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. in order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells.Universidade Federal de São Paulo, São Paulo, BrazilUniv Fed Minas Gerais, Minas Gerais, MG, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Arquivos Brasileiros CardiologiaUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de Minas Gerais (UFMG)Santos-Miranda, ArturCruz, Jader SantosRoman-Campos, Danilo [UNIFESP]2016-01-24T14:40:08Z2016-01-24T14:40:08Z2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion242-245application/pdfhttp://dx.doi.org/10.5935/abc.20150010Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 104, n. 3, p. 242-245, 2015.10.5935/abc.20150010S0066-782X2015000300010.pdf0066-782XS0066-782X2015000300010http://repositorio.unifesp.br/handle/11600/38806WOS:000353056200014engArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T19:57:25Zoai:repositorio.unifesp.br/:11600/38806Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T19:57:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
Propriedades Elétricas de Cardiomiócitos Isolados em um Modelo Animal em Ratos com Deficiência de Tiamina
title Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
spellingShingle Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
Santos-Miranda, Artur
Myocytes, Cardiac
Electric Stimulation
Thiamine Deficiency/physiopathology
Action Potentials
Rats, Heart Failure
title_short Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
title_full Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
title_fullStr Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
title_full_unstemmed Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
title_sort Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
author Santos-Miranda, Artur
author_facet Santos-Miranda, Artur
Cruz, Jader Santos
Roman-Campos, Danilo [UNIFESP]
author_role author
author2 Cruz, Jader Santos
Roman-Campos, Danilo [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
dc.contributor.author.fl_str_mv Santos-Miranda, Artur
Cruz, Jader Santos
Roman-Campos, Danilo [UNIFESP]
dc.subject.por.fl_str_mv Myocytes, Cardiac
Electric Stimulation
Thiamine Deficiency/physiopathology
Action Potentials
Rats, Heart Failure
topic Myocytes, Cardiac
Electric Stimulation
Thiamine Deficiency/physiopathology
Action Potentials
Rats, Heart Failure
description In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. in order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
2016-01-24T14:40:08Z
2016-01-24T14:40:08Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/abc.20150010
Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 104, n. 3, p. 242-245, 2015.
10.5935/abc.20150010
S0066-782X2015000300010.pdf
0066-782X
S0066-782X2015000300010
http://repositorio.unifesp.br/handle/11600/38806
WOS:000353056200014
url http://dx.doi.org/10.5935/abc.20150010
http://repositorio.unifesp.br/handle/11600/38806
identifier_str_mv Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 104, n. 3, p. 242-245, 2015.
10.5935/abc.20150010
S0066-782X2015000300010.pdf
0066-782X
S0066-782X2015000300010
WOS:000353056200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 242-245
application/pdf
dc.publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268323487023104

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