INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-86501999000200007 http://repositorio.unifesp.br/handle/11600/763 |
Resumo: | The purpose of this study is to evaluate the effect of the regional heparinization during temporary arterial ischemia performed in rabbits. The evaluated parameters served for measuring were activated partial thromboplastin times (aPTT) as well as the presence or absence of thrombi or endothelial edema in the analyzed vessels. Forty New Zealand rabbits were utilized. They were distributed into two groups of twenty animals. After dissection and repair of the left illiac artery, an arteriotomy was carried out and then a polyethylene catheter was fitted in so that heparin solution could be injected into the experimental group and physiological serum into the control group. The aPTT was measured at the beginning of the experiment and after ninety minutes of ischemia. There were no significant differences found from the initial values to the end of the experiment. Throughout microscopic evaluation the presence of thrombi in the vessels of the animals from both groups was not found. Intimal thickening as well as disruption of the middle layer regarded as endothelial edema ocurred in only one animal from the control group, however it was not considered a significant data. It was concluded that the injection of heparin (60 UI/kg weight) did not provoke significant alterations in the systemic coagulation of the rabbit. Furthermore, in the absence of endothelial lesion thrombosis of the analyzed vessels did not occur, neither with nor without the utilization of heparin. |
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INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOSInvestigation of the use of regional heparinization during temporary arterial ischemia performed in rabbitsHeparinIntra-arterial infusionsIschemiaArteriaRabbitsHeparinaInfusões intra-arteriaisIsquemiaArtériaCoelhoThe purpose of this study is to evaluate the effect of the regional heparinization during temporary arterial ischemia performed in rabbits. The evaluated parameters served for measuring were activated partial thromboplastin times (aPTT) as well as the presence or absence of thrombi or endothelial edema in the analyzed vessels. Forty New Zealand rabbits were utilized. They were distributed into two groups of twenty animals. After dissection and repair of the left illiac artery, an arteriotomy was carried out and then a polyethylene catheter was fitted in so that heparin solution could be injected into the experimental group and physiological serum into the control group. The aPTT was measured at the beginning of the experiment and after ninety minutes of ischemia. There were no significant differences found from the initial values to the end of the experiment. Throughout microscopic evaluation the presence of thrombi in the vessels of the animals from both groups was not found. Intimal thickening as well as disruption of the middle layer regarded as endothelial edema ocurred in only one animal from the control group, however it was not considered a significant data. It was concluded that the injection of heparin (60 UI/kg weight) did not provoke significant alterations in the systemic coagulation of the rabbit. Furthermore, in the absence of endothelial lesion thrombosis of the analyzed vessels did not occur, neither with nor without the utilization of heparin.O objetivo deste trabalho foi avaliar o efeito da heparinização regional durante a isquemia arterial temporária em coelhos. Os parâmetros avaliados foram a medida do tempo de tromboplastina parcial ativada (TTPa) e a presença ou ausência de trombos ou edema endotelial nos vasos estudados. Foram utilizados 40 coelhos Nova Zelândia, distribuídos em dois grupos de 20 animais. Após dissecção e reparo da artéria ilíaca esquerda, realizou uma arteriotomia e introduziu-se um cateter de polietileno para injeção de solução de heparina no grupo experimento ou de soro fisiológico no grupo controle. O TTPa foi medido no início do experimento e após 90 minutos de isquemia, não sendo encontrado diferenças significantes entre os valores iniciais e ao final do experimento. Na avaliação microscópica não foi encontrada a presença de trombos nos vasos dos animais de ambos os grupos. Em apenas um animal do grupo controle houve a ocorrência de espessamento intimal e desarranjo da camada média, interpretado como edema endotelial, porém este dado não foi significante. Concluiu-se que a injeção intra-arterial de heparina na dose de 60 UI/kg peso não provocou alterações significantes na coagulação sistêmica do coelho, e que na ausência de lesão endotelial não ocorreu trombose dos vasos estudados, com ou sem a utilização de heparina.Universidade Estadual de Maringá (UEM)UNIFESPEPMUEMUNIFESPEPMSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual de Maringá (UEM)Universidade Federal de São Paulo (UNIFESP)UEMMoreschi Junior, DorivalNigro, Amaury José Teixeira [UNIFESP]Bandeira, César Orlando PeraltaSeidel, Amélia Cristina [UNIFESP]Tormena, Eloísa de Brida2015-06-14T13:24:52Z2015-06-14T13:24:52Z1999-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://dx.doi.org/10.1590/S0102-86501999000200007Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 14, n. 2, p. 00-00, 1999.10.1590/S0102-86501999000200007S0102-86501999000200007.pdf0102-8650S0102-86501999000200007http://repositorio.unifesp.br/handle/11600/763porActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T19:53:46Zoai:repositorio.unifesp.br/:11600/763Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T19:53:46Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS Investigation of the use of regional heparinization during temporary arterial ischemia performed in rabbits |
title |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
spellingShingle |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS Moreschi Junior, Dorival Heparin Intra-arterial infusions Ischemia Arteria Rabbits Heparina Infusões intra-arteriais Isquemia Artéria Coelho |
title_short |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
title_full |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
title_fullStr |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
title_full_unstemmed |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
title_sort |
INVESTIGAÇÃO DO USO DE HEPARINIZAÇÃO REGIONAL DURANTE ISQUEMIA ARTERIAL TEMPORÁRIA EM COELHOS |
author |
Moreschi Junior, Dorival |
author_facet |
Moreschi Junior, Dorival Nigro, Amaury José Teixeira [UNIFESP] Bandeira, César Orlando Peralta Seidel, Amélia Cristina [UNIFESP] Tormena, Eloísa de Brida |
author_role |
author |
author2 |
Nigro, Amaury José Teixeira [UNIFESP] Bandeira, César Orlando Peralta Seidel, Amélia Cristina [UNIFESP] Tormena, Eloísa de Brida |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Maringá (UEM) Universidade Federal de São Paulo (UNIFESP) UEM |
dc.contributor.author.fl_str_mv |
Moreschi Junior, Dorival Nigro, Amaury José Teixeira [UNIFESP] Bandeira, César Orlando Peralta Seidel, Amélia Cristina [UNIFESP] Tormena, Eloísa de Brida |
dc.subject.por.fl_str_mv |
Heparin Intra-arterial infusions Ischemia Arteria Rabbits Heparina Infusões intra-arteriais Isquemia Artéria Coelho |
topic |
Heparin Intra-arterial infusions Ischemia Arteria Rabbits Heparina Infusões intra-arteriais Isquemia Artéria Coelho |
description |
The purpose of this study is to evaluate the effect of the regional heparinization during temporary arterial ischemia performed in rabbits. The evaluated parameters served for measuring were activated partial thromboplastin times (aPTT) as well as the presence or absence of thrombi or endothelial edema in the analyzed vessels. Forty New Zealand rabbits were utilized. They were distributed into two groups of twenty animals. After dissection and repair of the left illiac artery, an arteriotomy was carried out and then a polyethylene catheter was fitted in so that heparin solution could be injected into the experimental group and physiological serum into the control group. The aPTT was measured at the beginning of the experiment and after ninety minutes of ischemia. There were no significant differences found from the initial values to the end of the experiment. Throughout microscopic evaluation the presence of thrombi in the vessels of the animals from both groups was not found. Intimal thickening as well as disruption of the middle layer regarded as endothelial edema ocurred in only one animal from the control group, however it was not considered a significant data. It was concluded that the injection of heparin (60 UI/kg weight) did not provoke significant alterations in the systemic coagulation of the rabbit. Furthermore, in the absence of endothelial lesion thrombosis of the analyzed vessels did not occur, neither with nor without the utilization of heparin. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-04-01 2015-06-14T13:24:52Z 2015-06-14T13:24:52Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86501999000200007 Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 14, n. 2, p. 00-00, 1999. 10.1590/S0102-86501999000200007 S0102-86501999000200007.pdf 0102-8650 S0102-86501999000200007 http://repositorio.unifesp.br/handle/11600/763 |
url |
http://dx.doi.org/10.1590/S0102-86501999000200007 http://repositorio.unifesp.br/handle/11600/763 |
identifier_str_mv |
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 14, n. 2, p. 00-00, 1999. 10.1590/S0102-86501999000200007 S0102-86501999000200007.pdf 0102-8650 S0102-86501999000200007 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268413073162240 |