Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration

Detalhes bibliográficos
Autor(a) principal: Graim, Jair Francisco de Santana
Data de Publicação: 2008
Outros Autores: Lopes Filho, Gaspar de Jesus [UNIFESP], Brito, Marcus Vinicius Henriques, Matos, Lia Tavares de Moura Brasil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502008000200004
http://repositorio.unifesp.br/handle/11600/4335
Resumo: PURPOSE: To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats. METHODS: 60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment. RESULTS: Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups CONCLUSION: The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.
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spelling Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administrationEstudo histológico do fígado de ratos após administração de Croton Cajucara Benth (sacaca)PlantsMedicinalLiverPhytotherapic DrugsRatsPlantas MedicinaisFígadoMedicamentos FitoterápicosRatosPURPOSE: To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats. METHODS: 60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment. RESULTS: Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups CONCLUSION: The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.OBJETIVO: Avaliar histologicamente os efeitos do infuso, por gavagem, do Extrato Bruto Aquoso Seco (EBAS) do Croton cajucara Benth no fígado de ratos. MÉTODOS: Foram utilizados 60 ratos (Rattus novergicus albinus Wistar), pesando entre 250 e 350g. Os animais foram distribuídos de maneira aleatória em 2 grupos: GS - Grupo de animais que receberam 0,1ml/100g do infuso de sacaca, pela via oral e GA - Grupo de animais que recebeu 0,1ml/100g de água destilada, pela via oral. Estes foram distribuídos em 3 subgrupos de acordo com o dia da eutanásia, sendo esta realizada no 14º, 28º e 56º dia, cada um com 10 animais. RESULTADOS: Os resultados obtidos demonstraram que, microscopicamente, não houve alterações arquiteturais, porém quando se analisou a necrose hepatocitária, esta esteve presente em 50% do subgrupo GS28 e 90% do subgrupo GS56; as alterações inflamatórias puderam ser observadas tanto no subgrupo GS28 como no subgrupo GS56, sendo que neste último se fez presente em 80%, enquanto que no primeiro em apenas 20% dos animais submetidos ao experimento; 50% dos animais do subgrupo GS28 e 90% dos do subgrupo GS56 apresentaram extensa área de degeneração e necrose focal do hepatócito; em 100% dos animais tanto do GA como do GS não apresentaram qualquer alteração da veia centro-lobular. CONCLUSÃO: O infuso de Croton cajucara Benth (sacaca), nas condições deste experimento, foi capaz de determinar degeneração e necrose hepatocitária, sugerindo que a hepatotoxicidade à sacaca é dose dependente.State University of Pará Integrated Health DepartmentFederal University of São Paulo School of Medicine Surgical Gastroenterology DivisionUEPA Department of Integrated HealthUNIFESP, EPM, Surgical Gastroenterology DivisionSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaState University of Pará Integrated Health DepartmentUniversidade Federal de São Paulo (UNIFESP)UEPA Department of Integrated HealthGraim, Jair Francisco de SantanaLopes Filho, Gaspar de Jesus [UNIFESP]Brito, Marcus Vinicius HenriquesMatos, Lia Tavares de Moura Brasil2015-06-14T13:38:30Z2015-06-14T13:38:30Z2008-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion130-134application/pdfhttp://dx.doi.org/10.1590/S0102-86502008000200004Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 23, n. 2, p. 130-134, 2008.10.1590/S0102-86502008000200004S0102-86502008000200004.pdf0102-8650S0102-86502008000200004http://repositorio.unifesp.br/handle/11600/4335engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T22:47:43Zoai:repositorio.unifesp.br/:11600/4335Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T22:47:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
Estudo histológico do fígado de ratos após administração de Croton Cajucara Benth (sacaca)
title Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
spellingShingle Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
Graim, Jair Francisco de Santana
Plants
Medicinal
Liver
Phytotherapic Drugs
Rats
Plantas Medicinais
Fígado
Medicamentos Fitoterápicos
Ratos
title_short Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
title_full Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
title_fullStr Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
title_full_unstemmed Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
title_sort Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration
author Graim, Jair Francisco de Santana
author_facet Graim, Jair Francisco de Santana
Lopes Filho, Gaspar de Jesus [UNIFESP]
Brito, Marcus Vinicius Henriques
Matos, Lia Tavares de Moura Brasil
author_role author
author2 Lopes Filho, Gaspar de Jesus [UNIFESP]
Brito, Marcus Vinicius Henriques
Matos, Lia Tavares de Moura Brasil
author2_role author
author
author
dc.contributor.none.fl_str_mv State University of Pará Integrated Health Department
Universidade Federal de São Paulo (UNIFESP)
UEPA Department of Integrated Health
dc.contributor.author.fl_str_mv Graim, Jair Francisco de Santana
Lopes Filho, Gaspar de Jesus [UNIFESP]
Brito, Marcus Vinicius Henriques
Matos, Lia Tavares de Moura Brasil
dc.subject.por.fl_str_mv Plants
Medicinal
Liver
Phytotherapic Drugs
Rats
Plantas Medicinais
Fígado
Medicamentos Fitoterápicos
Ratos
topic Plants
Medicinal
Liver
Phytotherapic Drugs
Rats
Plantas Medicinais
Fígado
Medicamentos Fitoterápicos
Ratos
description PURPOSE: To evaluate the hepatic effect of Croton cajucara Benth (sacaca) herbal extract in rats. METHODS: 60 Wistar rats (Rattus novergicus albinus) were used, weighing between 250 and 350 g. The animals were distributed randomically in 2 groups: GS - animals which received daily 0,1 ml/ 100 g of sacaca herbal extract through gavage, and GA -animals which received daily 0,1 ml/100g of distilled water through gavage. These were distributed in 3 subgroups with 10 animals, according to theirs euthanasia dates, which were 14th, 28th and 56th day of treatment. RESULTS: Architectural alterations were not observed, however when it was analyzed the presence or absence of necrosis, it was observed in 50% of GS28 subgroup and 90% of subgroup. In 50% of the animals from GS28 subgroup and 90% of GS56 subgroup was observed vast degeneration areas and zonal necrosis, regarding center-lobular veins alterations, there were no alterations in any of the groups CONCLUSION: The Croton cajucara Benth (sacaca) herbal extract in this experiment caused degeneration and hepatic necrosis, suggesting dose-dependent action.
publishDate 2008
dc.date.none.fl_str_mv 2008-04-01
2015-06-14T13:38:30Z
2015-06-14T13:38:30Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502008000200004
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 23, n. 2, p. 130-134, 2008.
10.1590/S0102-86502008000200004
S0102-86502008000200004.pdf
0102-8650
S0102-86502008000200004
http://repositorio.unifesp.br/handle/11600/4335
url http://dx.doi.org/10.1590/S0102-86502008000200004
http://repositorio.unifesp.br/handle/11600/4335
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 23, n. 2, p. 130-134, 2008.
10.1590/S0102-86502008000200004
S0102-86502008000200004.pdf
0102-8650
S0102-86502008000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 130-134
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268274181931008

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