Inflammatory fibroid polyp: an immunohistochemical study
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0004-28032004000200007 http://repositorio.unifesp.br/handle/11600/2144 |
Resumo: | BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction. |
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Inflammatory fibroid polyp: an immunohistochemical studyPólipo inflamatório fibróide: estudo imunoistoquímicoPolypsImmunohistochemistryGastric mucosaGastrointestinal diseasesPóliposImunoistoquímicaMucosa gástricaGastroenteropatiasBACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.RACIONAL: O pólipo inflamatório fibróide é uma lesão localizada que se origina na submucosa do trato gastrointestinal, mais freqüentemente do estômago. Embora se acredite que represente condição reativa e não neoplásica, sua histogênese permanece controversa. OBJETIVO: Estudar o pólipo inflamatório fibróide por imunoistoquímica na tentativa de contribuir para o entendimento de sua histogênese. PACIENTES AND MÉTODOS: Foram estudados nove casos por imunoistoquímica usando-se um painel de anticorpos contra actina de músculo liso, vimentina, proteína S-100, fator VIII e macrófago (HAM-56). RESULTADOS: Houve um padrão difuso de coloração nas células fusiformes, fortemente positivo para vimentina. Um padrão focal de positividade para actina de músculo liso foi observado nessas células. O estudo revelou reação heterogênea com HAM-56. Nas áreas edematosas, as células positivas para HAM-56 mostraram citoplasma volumoso e núcleos reniformes. Nas áreas ricamente celulares, as células positivas para HAM-56 apresentaram citoplasma fusiforme. As reações para S-100 e fator VIII foram negativas nos elementos proliferantes. CONCLUSÕES: O presente estudo imunoistoquímico afasta a hipótese de natureza neural ou vascular da lesão. A forte positividade para vimentina em todos os casos sugere um componente principal de células fusiformes, melhor reconhecidas como fibroblastos. Estes resultados favoreceriam a existência de um espectro de padrões morfológicos e imunoistoquímicos, indicando, possivelmente, fases evolutivas de uma reação inflamatória.Federal University of São Paulo School of Medicine Department of PathologyAdolfo Lutz Institute Division of PathologyUniversity of São Paulo Faculty of Medicine of Ribeirão Preto Department of PathologyUNIFESP, EPM, Department of PathologySciELOInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBEDUniversidade Federal de São Paulo (UNIFESP)Adolfo Lutz Institute Division of PathologyUniversity of São Paulo Faculty of Medicine of Ribeirão Preto Department of PathologySantos, Gilda Da Cunha [UNIFESP]Alves, Venâncio A.f.Wakamatsu, AldaZucoloto, Sérgio2015-06-14T13:31:11Z2015-06-14T13:31:11Z2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion104-107application/pdfhttp://dx.doi.org/10.1590/S0004-28032004000200007Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004.10.1590/S0004-28032004000200007S0004-28032004000200007.pdf0004-2803S0004-28032004000200007http://repositorio.unifesp.br/handle/11600/2144engArquivos de Gastroenterologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T12:29:16Zoai:repositorio.unifesp.br/:11600/2144Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T12:29:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Inflammatory fibroid polyp: an immunohistochemical study Pólipo inflamatório fibróide: estudo imunoistoquímico |
title |
Inflammatory fibroid polyp: an immunohistochemical study |
spellingShingle |
Inflammatory fibroid polyp: an immunohistochemical study Santos, Gilda Da Cunha [UNIFESP] Polyps Immunohistochemistry Gastric mucosa Gastrointestinal diseases Pólipos Imunoistoquímica Mucosa gástrica Gastroenteropatias |
title_short |
Inflammatory fibroid polyp: an immunohistochemical study |
title_full |
Inflammatory fibroid polyp: an immunohistochemical study |
title_fullStr |
Inflammatory fibroid polyp: an immunohistochemical study |
title_full_unstemmed |
Inflammatory fibroid polyp: an immunohistochemical study |
title_sort |
Inflammatory fibroid polyp: an immunohistochemical study |
author |
Santos, Gilda Da Cunha [UNIFESP] |
author_facet |
Santos, Gilda Da Cunha [UNIFESP] Alves, Venâncio A.f. Wakamatsu, Alda Zucoloto, Sérgio |
author_role |
author |
author2 |
Alves, Venâncio A.f. Wakamatsu, Alda Zucoloto, Sérgio |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Adolfo Lutz Institute Division of Pathology University of São Paulo Faculty of Medicine of Ribeirão Preto Department of Pathology |
dc.contributor.author.fl_str_mv |
Santos, Gilda Da Cunha [UNIFESP] Alves, Venâncio A.f. Wakamatsu, Alda Zucoloto, Sérgio |
dc.subject.por.fl_str_mv |
Polyps Immunohistochemistry Gastric mucosa Gastrointestinal diseases Pólipos Imunoistoquímica Mucosa gástrica Gastroenteropatias |
topic |
Polyps Immunohistochemistry Gastric mucosa Gastrointestinal diseases Pólipos Imunoistoquímica Mucosa gástrica Gastroenteropatias |
description |
BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-06-01 2015-06-14T13:31:11Z 2015-06-14T13:31:11Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-28032004000200007 Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004. 10.1590/S0004-28032004000200007 S0004-28032004000200007.pdf 0004-2803 S0004-28032004000200007 http://repositorio.unifesp.br/handle/11600/2144 |
url |
http://dx.doi.org/10.1590/S0004-28032004000200007 http://repositorio.unifesp.br/handle/11600/2144 |
identifier_str_mv |
Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004. 10.1590/S0004-28032004000200007 S0004-28032004000200007.pdf 0004-2803 S0004-28032004000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Gastroenterologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
104-107 application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED |
publisher.none.fl_str_mv |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268347331641344 |