Inflammatory fibroid polyp: an immunohistochemical study

Detalhes bibliográficos
Autor(a) principal: Santos, Gilda Da Cunha [UNIFESP]
Data de Publicação: 2004
Outros Autores: Alves, Venâncio A.f., Wakamatsu, Alda, Zucoloto, Sérgio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-28032004000200007
http://repositorio.unifesp.br/handle/11600/2144
Resumo: BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.
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spelling Inflammatory fibroid polyp: an immunohistochemical studyPólipo inflamatório fibróide: estudo imunoistoquímicoPolypsImmunohistochemistryGastric mucosaGastrointestinal diseasesPóliposImunoistoquímicaMucosa gástricaGastroenteropatiasBACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.RACIONAL: O pólipo inflamatório fibróide é uma lesão localizada que se origina na submucosa do trato gastrointestinal, mais freqüentemente do estômago. Embora se acredite que represente condição reativa e não neoplásica, sua histogênese permanece controversa. OBJETIVO: Estudar o pólipo inflamatório fibróide por imunoistoquímica na tentativa de contribuir para o entendimento de sua histogênese. PACIENTES AND MÉTODOS: Foram estudados nove casos por imunoistoquímica usando-se um painel de anticorpos contra actina de músculo liso, vimentina, proteína S-100, fator VIII e macrófago (HAM-56). RESULTADOS: Houve um padrão difuso de coloração nas células fusiformes, fortemente positivo para vimentina. Um padrão focal de positividade para actina de músculo liso foi observado nessas células. O estudo revelou reação heterogênea com HAM-56. Nas áreas edematosas, as células positivas para HAM-56 mostraram citoplasma volumoso e núcleos reniformes. Nas áreas ricamente celulares, as células positivas para HAM-56 apresentaram citoplasma fusiforme. As reações para S-100 e fator VIII foram negativas nos elementos proliferantes. CONCLUSÕES: O presente estudo imunoistoquímico afasta a hipótese de natureza neural ou vascular da lesão. A forte positividade para vimentina em todos os casos sugere um componente principal de células fusiformes, melhor reconhecidas como fibroblastos. Estes resultados favoreceriam a existência de um espectro de padrões morfológicos e imunoistoquímicos, indicando, possivelmente, fases evolutivas de uma reação inflamatória.Federal University of São Paulo School of Medicine Department of PathologyAdolfo Lutz Institute Division of PathologyUniversity of São Paulo Faculty of Medicine of Ribeirão Preto Department of PathologyUNIFESP, EPM, Department of PathologySciELOInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBEDUniversidade Federal de São Paulo (UNIFESP)Adolfo Lutz Institute Division of PathologyUniversity of São Paulo Faculty of Medicine of Ribeirão Preto Department of PathologySantos, Gilda Da Cunha [UNIFESP]Alves, Venâncio A.f.Wakamatsu, AldaZucoloto, Sérgio2015-06-14T13:31:11Z2015-06-14T13:31:11Z2004-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion104-107application/pdfhttp://dx.doi.org/10.1590/S0004-28032004000200007Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004.10.1590/S0004-28032004000200007S0004-28032004000200007.pdf0004-2803S0004-28032004000200007http://repositorio.unifesp.br/handle/11600/2144engArquivos de Gastroenterologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T12:29:16Zoai:repositorio.unifesp.br/:11600/2144Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T12:29:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Inflammatory fibroid polyp: an immunohistochemical study
Pólipo inflamatório fibróide: estudo imunoistoquímico
title Inflammatory fibroid polyp: an immunohistochemical study
spellingShingle Inflammatory fibroid polyp: an immunohistochemical study
Santos, Gilda Da Cunha [UNIFESP]
Polyps
Immunohistochemistry
Gastric mucosa
Gastrointestinal diseases
Pólipos
Imunoistoquímica
Mucosa gástrica
Gastroenteropatias
title_short Inflammatory fibroid polyp: an immunohistochemical study
title_full Inflammatory fibroid polyp: an immunohistochemical study
title_fullStr Inflammatory fibroid polyp: an immunohistochemical study
title_full_unstemmed Inflammatory fibroid polyp: an immunohistochemical study
title_sort Inflammatory fibroid polyp: an immunohistochemical study
author Santos, Gilda Da Cunha [UNIFESP]
author_facet Santos, Gilda Da Cunha [UNIFESP]
Alves, Venâncio A.f.
Wakamatsu, Alda
Zucoloto, Sérgio
author_role author
author2 Alves, Venâncio A.f.
Wakamatsu, Alda
Zucoloto, Sérgio
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Adolfo Lutz Institute Division of Pathology
University of São Paulo Faculty of Medicine of Ribeirão Preto Department of Pathology
dc.contributor.author.fl_str_mv Santos, Gilda Da Cunha [UNIFESP]
Alves, Venâncio A.f.
Wakamatsu, Alda
Zucoloto, Sérgio
dc.subject.por.fl_str_mv Polyps
Immunohistochemistry
Gastric mucosa
Gastrointestinal diseases
Pólipos
Imunoistoquímica
Mucosa gástrica
Gastroenteropatias
topic Polyps
Immunohistochemistry
Gastric mucosa
Gastrointestinal diseases
Pólipos
Imunoistoquímica
Mucosa gástrica
Gastroenteropatias
description BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.
publishDate 2004
dc.date.none.fl_str_mv 2004-06-01
2015-06-14T13:31:11Z
2015-06-14T13:31:11Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-28032004000200007
Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004.
10.1590/S0004-28032004000200007
S0004-28032004000200007.pdf
0004-2803
S0004-28032004000200007
http://repositorio.unifesp.br/handle/11600/2144
url http://dx.doi.org/10.1590/S0004-28032004000200007
http://repositorio.unifesp.br/handle/11600/2144
identifier_str_mv Arquivos de Gastroenterologia. Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED, v. 41, n. 2, p. 104-107, 2004.
10.1590/S0004-28032004000200007
S0004-28032004000200007.pdf
0004-2803
S0004-28032004000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Gastroenterologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 104-107
application/pdf
dc.publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED
publisher.none.fl_str_mv Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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