Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35700 http://dx.doi.org/10.1155/2013/609019 |
Resumo: | Alzheimer's disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains. AD is the outcome of a complex interaction among several factors which are not fully understood yet; nevertheless, it is clear that oxidative stress and inflammatory pathways are among these factors. 65 elderly subjects (42 cognitively intact and 23 with probable Alzheimer's disease) were selected for this study. We evaluated erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase as well as plasma levels of total glutathione, alpha-tocopherol, beta-carotene, lycopene, and coenzyme Q10. These antioxidant parameters were confronted with plasmatic levels of protein and lipid oxidation products. Additionally, we measured basal expression of monocyte HLA-DR and CD-11b, as well as monocyte production of cytokines IL1-alpha, IL-6, and TNF-alpha. AD patients presented lower plasmatic levels of alpha-tocopherol when compared to control ones and also higher basal monocyte HLA-DR expression associated with higher IL-1 alpha production when stimulated by LPS. These findings support the inflammatory theory of AD and point out that this disease is associated with a higher basal activation of circulating monocytes that may be a result of alpha-tocopherol stock depletion. |
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Giavarotti, LeandroSimon, Karin A. [UNIFESP]Azzalis, Ligia A. [UNIFESP]Fonseca, Fernando L. A. [UNIFESP]Lima, Alessandra F. [UNIFESP]Freitas, Maria C. V. [UNIFESP]Brunialti, Milena K. C. [UNIFESP]Salomao, Reinaldo [UNIFESP]Moscardi, Alcione A. V. S. [UNIFESP]Montano, Maria B. M. M. [UNIFESP]Ramos, Luiz R. [UNIFESP]Junqueira, Virginia B. C. [UNIFESP]Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)FMABC2016-01-24T14:30:54Z2016-01-24T14:30:54Z2013-01-01Oxidative Medicine and Cellular Longevity. New York: Hindawi Publishing Corporation, 8 p., 2013.1942-0900http://repositorio.unifesp.br/handle/11600/35700http://dx.doi.org/10.1155/2013/609019WOS000328995200001.pdf10.1155/2013/609019WOS:000328995200001Alzheimer's disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains. AD is the outcome of a complex interaction among several factors which are not fully understood yet; nevertheless, it is clear that oxidative stress and inflammatory pathways are among these factors. 65 elderly subjects (42 cognitively intact and 23 with probable Alzheimer's disease) were selected for this study. We evaluated erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase as well as plasma levels of total glutathione, alpha-tocopherol, beta-carotene, lycopene, and coenzyme Q10. These antioxidant parameters were confronted with plasmatic levels of protein and lipid oxidation products. Additionally, we measured basal expression of monocyte HLA-DR and CD-11b, as well as monocyte production of cytokines IL1-alpha, IL-6, and TNF-alpha. AD patients presented lower plasmatic levels of alpha-tocopherol when compared to control ones and also higher basal monocyte HLA-DR expression associated with higher IL-1 alpha production when stimulated by LPS. These findings support the inflammatory theory of AD and point out that this disease is associated with a higher basal activation of circulating monocytes that may be a result of alpha-tocopherol stock depletion.Univ São Paulo, Inst Quim, BR-05508900 São Paulo, BrazilUNIFESP, Inst Ciencias Ambientais Quim Farmaceut, BR-09972270 Diadema, SP, BrazilFMABC, Dept Hematol & Oncol, BR-09060650 Santo Andre, SP, BrazilUniversidade Federal de São Paulo, Dept Med, BR-04021001 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med Prevent, BR-04021001 São Paulo, BrazilUNIFESP, Inst Ciencias Ambientais Quim Farmaceut, BR-09972270 Diadema, SP, BrazilUniversidade Federal de São Paulo, Dept Med, BR-04021001 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med Prevent, BR-04021001 São Paulo, BrazilWeb of Science8engHindawi Publishing CorporationOxidative Medicine and Cellular LongevityMild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000328995200001.pdfapplication/pdf2548434${dspace.ui.url}/bitstream/11600/35700/1/WOS000328995200001.pdfdeb50980eeaee3e8718263b411f47cc8MD51open accessTEXTWOS000328995200001.pdf.txtWOS000328995200001.pdf.txtExtracted texttext/plain38319${dspace.ui.url}/bitstream/11600/35700/9/WOS000328995200001.pdf.txt27b0cdb4d3e9f773f314ced0bf3a0b3fMD59open accessTHUMBNAILWOS000328995200001.pdf.jpgWOS000328995200001.pdf.jpgIM Thumbnailimage/jpeg7034${dspace.ui.url}/bitstream/11600/35700/11/WOS000328995200001.pdf.jpg752ece0129c5aa425467ad4dc775ff25MD511open access11600/357002023-06-05 19:26:11.62open accessoai:repositorio.unifesp.br:11600/35700Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:26:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
title |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
spellingShingle |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease Giavarotti, Leandro |
title_short |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
title_full |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
title_fullStr |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
title_full_unstemmed |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
title_sort |
Mild Systemic Oxidative Stress in the Subclinical Stage of Alzheimer's Disease |
author |
Giavarotti, Leandro |
author_facet |
Giavarotti, Leandro Simon, Karin A. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] Lima, Alessandra F. [UNIFESP] Freitas, Maria C. V. [UNIFESP] Brunialti, Milena K. C. [UNIFESP] Salomao, Reinaldo [UNIFESP] Moscardi, Alcione A. V. S. [UNIFESP] Montano, Maria B. M. M. [UNIFESP] Ramos, Luiz R. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] |
author_role |
author |
author2 |
Simon, Karin A. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] Lima, Alessandra F. [UNIFESP] Freitas, Maria C. V. [UNIFESP] Brunialti, Milena K. C. [UNIFESP] Salomao, Reinaldo [UNIFESP] Moscardi, Alcione A. V. S. [UNIFESP] Montano, Maria B. M. M. [UNIFESP] Ramos, Luiz R. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) FMABC |
dc.contributor.author.fl_str_mv |
Giavarotti, Leandro Simon, Karin A. [UNIFESP] Azzalis, Ligia A. [UNIFESP] Fonseca, Fernando L. A. [UNIFESP] Lima, Alessandra F. [UNIFESP] Freitas, Maria C. V. [UNIFESP] Brunialti, Milena K. C. [UNIFESP] Salomao, Reinaldo [UNIFESP] Moscardi, Alcione A. V. S. [UNIFESP] Montano, Maria B. M. M. [UNIFESP] Ramos, Luiz R. [UNIFESP] Junqueira, Virginia B. C. [UNIFESP] |
description |
Alzheimer's disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains. AD is the outcome of a complex interaction among several factors which are not fully understood yet; nevertheless, it is clear that oxidative stress and inflammatory pathways are among these factors. 65 elderly subjects (42 cognitively intact and 23 with probable Alzheimer's disease) were selected for this study. We evaluated erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase as well as plasma levels of total glutathione, alpha-tocopherol, beta-carotene, lycopene, and coenzyme Q10. These antioxidant parameters were confronted with plasmatic levels of protein and lipid oxidation products. Additionally, we measured basal expression of monocyte HLA-DR and CD-11b, as well as monocyte production of cytokines IL1-alpha, IL-6, and TNF-alpha. AD patients presented lower plasmatic levels of alpha-tocopherol when compared to control ones and also higher basal monocyte HLA-DR expression associated with higher IL-1 alpha production when stimulated by LPS. These findings support the inflammatory theory of AD and point out that this disease is associated with a higher basal activation of circulating monocytes that may be a result of alpha-tocopherol stock depletion. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:30:54Z |
dc.date.available.fl_str_mv |
2016-01-24T14:30:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Oxidative Medicine and Cellular Longevity. New York: Hindawi Publishing Corporation, 8 p., 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35700 http://dx.doi.org/10.1155/2013/609019 |
dc.identifier.issn.none.fl_str_mv |
1942-0900 |
dc.identifier.file.none.fl_str_mv |
WOS000328995200001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2013/609019 |
dc.identifier.wos.none.fl_str_mv |
WOS:000328995200001 |
identifier_str_mv |
Oxidative Medicine and Cellular Longevity. New York: Hindawi Publishing Corporation, 8 p., 2013. 1942-0900 WOS000328995200001.pdf 10.1155/2013/609019 WOS:000328995200001 |
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http://repositorio.unifesp.br/handle/11600/35700 http://dx.doi.org/10.1155/2013/609019 |
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eng |
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Oxidative Medicine and Cellular Longevity |
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Hindawi Publishing Corporation |
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