Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Mauricio Martins [UNIFESP]
Data de Publicação: 1991
Outros Autores: Dutra, Araripe P., Yoshida, Nobuko [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/00130000151qb
DOI: 10.1590/S0074-02761991000200003
Texto Completo: http://dx.doi.org/10.1590/S0074-02761991000200003
http://repositorio.unifesp.br/handle/11600/281
Resumo: The cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.
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spelling Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivaxcircumsporozoite proteinsporozoite immunitymalariaT cell epitopesThe cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.New York University Department of Medical and Molecular ParasitologySuperintendência de Controle de EndemiasEscola Paulista de Medicina Disciplina de ParasitologiaUNIFESP, EPM, Disciplina de ParasitologiaSciELOInstituto Oswaldo Cruz, Ministério da SaúdeNew York University Department of Medical and Molecular ParasitologySuperintendência de Controle de EndemiasUniversidade Federal de São Paulo (UNIFESP)Rodrigues, Mauricio Martins [UNIFESP]Dutra, Araripe P.Yoshida, Nobuko [UNIFESP]2015-06-14T13:24:21Z2015-06-14T13:24:21Z1991-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion153-158application/pdfhttp://dx.doi.org/10.1590/S0074-02761991000200003Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.10.1590/S0074-02761991000200003S0074-02761991000200003.pdf0074-0276S0074-02761991000200003http://repositorio.unifesp.br/handle/11600/281WOS:A1991GB98100003ark:/48912/00130000151qbengMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T21:11:54Zoai:repositorio.unifesp.br/:11600/281Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:56:40.866995Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
title Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
spellingShingle Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
Rodrigues, Mauricio Martins [UNIFESP]
circumsporozoite protein
sporozoite immunity
malaria
T cell epitopes
Rodrigues, Mauricio Martins [UNIFESP]
circumsporozoite protein
sporozoite immunity
malaria
T cell epitopes
title_short Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
title_full Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
title_fullStr Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
title_full_unstemmed Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
title_sort Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax
author Rodrigues, Mauricio Martins [UNIFESP]
author_facet Rodrigues, Mauricio Martins [UNIFESP]
Rodrigues, Mauricio Martins [UNIFESP]
Dutra, Araripe P.
Yoshida, Nobuko [UNIFESP]
Dutra, Araripe P.
Yoshida, Nobuko [UNIFESP]
author_role author
author2 Dutra, Araripe P.
Yoshida, Nobuko [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv New York University Department of Medical and Molecular Parasitology
Superintendência de Controle de Endemias
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Rodrigues, Mauricio Martins [UNIFESP]
Dutra, Araripe P.
Yoshida, Nobuko [UNIFESP]
dc.subject.por.fl_str_mv circumsporozoite protein
sporozoite immunity
malaria
T cell epitopes
topic circumsporozoite protein
sporozoite immunity
malaria
T cell epitopes
description The cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.
publishDate 1991
dc.date.none.fl_str_mv 1991-06-01
2015-06-14T13:24:21Z
2015-06-14T13:24:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0074-02761991000200003
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.
10.1590/S0074-02761991000200003
S0074-02761991000200003.pdf
0074-0276
S0074-02761991000200003
http://repositorio.unifesp.br/handle/11600/281
WOS:A1991GB98100003
dc.identifier.dark.fl_str_mv ark:/48912/00130000151qb
url http://dx.doi.org/10.1590/S0074-02761991000200003
http://repositorio.unifesp.br/handle/11600/281
identifier_str_mv Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.
10.1590/S0074-02761991000200003
S0074-02761991000200003.pdf
0074-0276
S0074-02761991000200003
WOS:A1991GB98100003
ark:/48912/00130000151qb
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 153-158
application/pdf
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822183987691388928
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761991000200003

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