Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet

Detalhes bibliográficos
Autor(a) principal: Chang, Eun Hyuk
Data de Publicação: 2016
Outros Autores: Adorjan, Istvan, Mundim, Mayara V. [UNIFESP], Sun, Bin, Dizon, Maria L. V., Szele, Francis G.
Tipo de documento: Artigo (review)
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3339/fnins.2016.00332
http://repositorio.unifesp.br/handle/11600/51177
Resumo: Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.
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spelling Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichetadult neurogenesisstem cellstraumatic brain injury (TBI)regenerationproliferationTraumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.Samsung Elect Co Ltd, Samsung Biomed Res Inst, Samsung Adv Inst Technol, Seoul, South KoreaUniv Oxford, Dept Physiol Anat & Genet, Oxford, EnglandSemmelweis Univ, Dept Anat Histol & Embryol, Budapest, HungaryUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, BrazilNorthwestern Univ, Dept Pediat, Prentice Womens Hosp, Feinbera Sch Med, Chicago, IL 60611 USAUniv Fed Sao Paulo, Dept Biochem, Sao Paulo, BrazilWeb of ScienceNIH RO1 NIH/NINDS [R01NS086945-01]MRC/NNSFC project [MR/M010554/1]China Scholarship CouncilHenry Lester TrustFAPESP [2012/06810-1, 2014/00927-0]NIH/NINDS:R01NS086945-01MRC/NNSFC project:MR/M010554/1FAPESP:2012/06810-12014/00927-0Frontiers Media Sa2019-07-22T15:46:55Z2019-07-22T15:46:55Z2016info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.3339/fnins.2016.00332Frontiers In Neuroscience. Lausanne, v. 10, p. -, 2016.10.3339/fnins.2016.00332WOS000381085600001.pdf1662-453Xhttp://repositorio.unifesp.br/handle/11600/51177WOS:000381085600001enginfo:eu-repo/semantics/openAccessChang, Eun HyukAdorjan, IstvanMundim, Mayara V. [UNIFESP]Sun, BinDizon, Maria L. V.Szele, Francis G.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-29T14:56:23Zoai:repositorio.unifesp.br/:11600/51177Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-29T14:56:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
title Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
spellingShingle Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
Chang, Eun Hyuk
adult neurogenesis
stem cells
traumatic brain injury (TBI)
regeneration
proliferation
title_short Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
title_full Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
title_fullStr Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
title_full_unstemmed Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
title_sort Traumatic Brain Injury Activation of the Adult Subventricular Zone Neurogenic Nichet
author Chang, Eun Hyuk
author_facet Chang, Eun Hyuk
Adorjan, Istvan
Mundim, Mayara V. [UNIFESP]
Sun, Bin
Dizon, Maria L. V.
Szele, Francis G.
author_role author
author2 Adorjan, Istvan
Mundim, Mayara V. [UNIFESP]
Sun, Bin
Dizon, Maria L. V.
Szele, Francis G.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Chang, Eun Hyuk
Adorjan, Istvan
Mundim, Mayara V. [UNIFESP]
Sun, Bin
Dizon, Maria L. V.
Szele, Francis G.
dc.subject.por.fl_str_mv adult neurogenesis
stem cells
traumatic brain injury (TBI)
regeneration
proliferation
topic adult neurogenesis
stem cells
traumatic brain injury (TBI)
regeneration
proliferation
description Traumatic brain injury (TBI) is common in both civilian and military life, placing a large burden on survivors and society. However, with the recognition of neural stem cells in adult mammals, including humans, came the possibility to harness these cells for repair of damaged brain, whereas previously this was thought to be impossible. In this review, we focus on the rodent adult subventricular zone (SVZ), an important neurogenic niche within the mature brain in which neural stem cells continue to reside. We review how the SVZ is perturbed following various animal TBI models with regards to cell proliferation, emigration, survival, and differentiation, and we review specific molecules involved in these processes. Together, this information suggests next steps in attempting to translate knowledge from TBI animal models into human therapies for TBI.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019-07-22T15:46:55Z
2019-07-22T15:46:55Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/review
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format review
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3339/fnins.2016.00332
Frontiers In Neuroscience. Lausanne, v. 10, p. -, 2016.
10.3339/fnins.2016.00332
WOS000381085600001.pdf
1662-453X
http://repositorio.unifesp.br/handle/11600/51177
WOS:000381085600001
url http://dx.doi.org/10.3339/fnins.2016.00332
http://repositorio.unifesp.br/handle/11600/51177
identifier_str_mv Frontiers In Neuroscience. Lausanne, v. 10, p. -, 2016.
10.3339/fnins.2016.00332
WOS000381085600001.pdf
1662-453X
WOS:000381085600001
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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