Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36877 http://dx.doi.org/10.1186/1471-2431-13-168 |
Resumo: | Background: the project proposes three innovative intervention techniques (treadmill training, mobility training with virtual reality and transcranial direct current stimulation that can be safely administered to children with cerebral palsy. the combination of transcranial stimulation and physical therapy resources will provide the training of a specific task with multiple rhythmic repetitions of the phases of the gait cycle, providing rich sensory stimuli with a modified excitability threshold of the primary motor cortex to enhance local synaptic efficacy and potentiate motor learning.Methods/design: A prospective, double-blind, randomized, controlled, analytical, clinical trial will be carried out. Eligible participants will be children with cerebral palsy classified on levels I, II and III of the Gross Motor Function Classification System between four and ten years of age. the participants will be randomly allocated to four groups: 1) gait training on a treadmill with placebo transcranial stimulation; 2) gait training on a treadmill with active transcranial stimulation; 3) mobility training with virtual reality and placebo transcranial stimulation; 4) mobility training with virtual reality and active transcranial stimulation. Transcranial direct current stimulation will be applied with the anodal electrode positioned in the region of the dominant hemisphere over C3, corresponding to the primary motor cortex, and the cathode positioned in the supraorbital region contralateral to the anode. A 1 mA current will be applied for 20 minutes. Treadmill training and mobility training with virtual reality will be performed in 30-minute sessions five times a week for two weeks (total of 10 sessions). Evaluations will be performed on four occasions: one week prior to the intervention; one week following the intervention; one month after the end of the intervention; and 3 months after the end of the intervention. the evaluations will involve three-dimensional gait analysis, analysis of cortex excitability (motor threshold and motor evoked potential), Six-Minute Walk Test, Timed Up-and-Go Test, Pediatric Evaluation Disability Inventory, Gross Motor Function Measure, Berg Balance Scale, stabilometry, maximum respiratory pressure and an effort test.Discussion: This paper offers a detailed description of a prospective, double-blind, randomized, controlled, analytical, clinical trial aimed at demonstrating the effect combining transcranial stimulation with treadmill and mobility training on functionality and primary cortex excitability in children with Cerebral Palsy classified on Gross Motor Function Classification System levels I, II and III. the results will be published and will contribute to evidence regarding the use of treadmill training on this population. |
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Grecco, Luanda Andre CollangeDuarte, Natalia de Almeida CarvalhoMendonca, Mariana Emerenciano dePasini, HugoLima, Vania Lucia Costa de Carvalho [UNIFESP]Franco, Renata CalhesOliveira, Luis Vicente Franco deCarvalho, Paulo de Tarso Camilo deCorrea, Joao Carlos FerrariCollange, Nelci ZanonSampaio, Luciana Maria MalosaGalli, ManuelaFregni, FelipeOliveira, Claudia SantosUniv Nove Julho UNINOVEUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Fed Pediat Neurosurg Ctr CENEPEPolitecn MilanSpaulding Rehabil HospHarvard Univ2016-01-24T14:34:35Z2016-01-24T14:34:35Z2013-10-11Bmc Pediatrics. London: Biomed Central Ltd, v. 13, 11 p., 2013.1471-2431http://repositorio.unifesp.br/handle/11600/36877http://dx.doi.org/10.1186/1471-2431-13-168WOS000327494300001.pdf10.1186/1471-2431-13-168WOS:000327494300001Background: the project proposes three innovative intervention techniques (treadmill training, mobility training with virtual reality and transcranial direct current stimulation that can be safely administered to children with cerebral palsy. the combination of transcranial stimulation and physical therapy resources will provide the training of a specific task with multiple rhythmic repetitions of the phases of the gait cycle, providing rich sensory stimuli with a modified excitability threshold of the primary motor cortex to enhance local synaptic efficacy and potentiate motor learning.Methods/design: A prospective, double-blind, randomized, controlled, analytical, clinical trial will be carried out. Eligible participants will be children with cerebral palsy classified on levels I, II and III of the Gross Motor Function Classification System between four and ten years of age. the participants will be randomly allocated to four groups: 1) gait training on a treadmill with placebo transcranial stimulation; 2) gait training on a treadmill with active transcranial stimulation; 3) mobility training with virtual reality and placebo transcranial stimulation; 4) mobility training with virtual reality and active transcranial stimulation. Transcranial direct current stimulation will be applied with the anodal electrode positioned in the region of the dominant hemisphere over C3, corresponding to the primary motor cortex, and the cathode positioned in the supraorbital region contralateral to the anode. A 1 mA current will be applied for 20 minutes. Treadmill training and mobility training with virtual reality will be performed in 30-minute sessions five times a week for two weeks (total of 10 sessions). Evaluations will be performed on four occasions: one week prior to the intervention; one week following the intervention; one month after the end of the intervention; and 3 months after the end of the intervention. the evaluations will involve three-dimensional gait analysis, analysis of cortex excitability (motor threshold and motor evoked potential), Six-Minute Walk Test, Timed Up-and-Go Test, Pediatric Evaluation Disability Inventory, Gross Motor Function Measure, Berg Balance Scale, stabilometry, maximum respiratory pressure and an effort test.Discussion: This paper offers a detailed description of a prospective, double-blind, randomized, controlled, analytical, clinical trial aimed at demonstrating the effect combining transcranial stimulation with treadmill and mobility training on functionality and primary cortex excitability in children with Cerebral Palsy classified on Gross Motor Function Classification System levels I, II and III. the results will be published and will contribute to evidence regarding the use of treadmill training on this population.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Nove Julho UNINOVE, Masters & Doctoral Programs Rehabil Sci, São Paulo, BrazilUniv São Paulo, Inst Psychol, Doctoral Program, São Paulo, BrazilUniversidade Federal de São Paulo, Masters & Doctoral Programs Commun Disordes Speec, São Paulo, BrazilUniv São Paulo, São Paulo, BrazilFed Pediat Neurosurg Ctr CENEPE, São Paulo, BrazilPolitecn Milan, Dipartimento Bioingn, I-20133 Milan, ItalySpaulding Rehabil Hosp, Lab Neuromodulat, Boston, MA USASpaulding Rehabil Hosp, Ctr Clin Res Learning, Dept Phys Med & Rehabil, Boston, MA USAHarvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USAUniversidade Federal de São Paulo, Masters & Doctoral Programs Commun Disordes Speec, São Paulo, BrazilWeb of Science11engBiomed Central LtdBmc PediatricsCerebral palsyChildPhysiotherapyCerebral cortexElectrical stimulationEffect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000327494300001.pdfapplication/pdf367924${dspace.ui.url}/bitstream/11600/36877/1/WOS000327494300001.pdfc13693baaf363d059f5d9a537047ee85MD51open accessTEXTWOS000327494300001.pdf.txtWOS000327494300001.pdf.txtExtracted texttext/plain60132${dspace.ui.url}/bitstream/11600/36877/2/WOS000327494300001.pdf.txt794588273a039a843745fd3123dc0b18MD52open access11600/368772022-09-27 09:48:35.601open accessoai:repositorio.unifesp.br:11600/36877Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:23:36.982267Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
title |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
spellingShingle |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial Grecco, Luanda Andre Collange Cerebral palsy Child Physiotherapy Cerebral cortex Electrical stimulation |
title_short |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
title_full |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
title_fullStr |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
title_full_unstemmed |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
title_sort |
Effect of transcranial direct current stimulation combined with gait and mobility training on functionality in children with cerebral palsy: study protocol for a double-blind randomized controlled clinical trial |
author |
Grecco, Luanda Andre Collange |
author_facet |
Grecco, Luanda Andre Collange Duarte, Natalia de Almeida Carvalho Mendonca, Mariana Emerenciano de Pasini, Hugo Lima, Vania Lucia Costa de Carvalho [UNIFESP] Franco, Renata Calhes Oliveira, Luis Vicente Franco de Carvalho, Paulo de Tarso Camilo de Correa, Joao Carlos Ferrari Collange, Nelci Zanon Sampaio, Luciana Maria Malosa Galli, Manuela Fregni, Felipe Oliveira, Claudia Santos |
author_role |
author |
author2 |
Duarte, Natalia de Almeida Carvalho Mendonca, Mariana Emerenciano de Pasini, Hugo Lima, Vania Lucia Costa de Carvalho [UNIFESP] Franco, Renata Calhes Oliveira, Luis Vicente Franco de Carvalho, Paulo de Tarso Camilo de Correa, Joao Carlos Ferrari Collange, Nelci Zanon Sampaio, Luciana Maria Malosa Galli, Manuela Fregni, Felipe Oliveira, Claudia Santos |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Nove Julho UNINOVE Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Fed Pediat Neurosurg Ctr CENEPE Politecn Milan Spaulding Rehabil Hosp Harvard Univ |
dc.contributor.author.fl_str_mv |
Grecco, Luanda Andre Collange Duarte, Natalia de Almeida Carvalho Mendonca, Mariana Emerenciano de Pasini, Hugo Lima, Vania Lucia Costa de Carvalho [UNIFESP] Franco, Renata Calhes Oliveira, Luis Vicente Franco de Carvalho, Paulo de Tarso Camilo de Correa, Joao Carlos Ferrari Collange, Nelci Zanon Sampaio, Luciana Maria Malosa Galli, Manuela Fregni, Felipe Oliveira, Claudia Santos |
dc.subject.eng.fl_str_mv |
Cerebral palsy Child Physiotherapy Cerebral cortex Electrical stimulation |
topic |
Cerebral palsy Child Physiotherapy Cerebral cortex Electrical stimulation |
description |
Background: the project proposes three innovative intervention techniques (treadmill training, mobility training with virtual reality and transcranial direct current stimulation that can be safely administered to children with cerebral palsy. the combination of transcranial stimulation and physical therapy resources will provide the training of a specific task with multiple rhythmic repetitions of the phases of the gait cycle, providing rich sensory stimuli with a modified excitability threshold of the primary motor cortex to enhance local synaptic efficacy and potentiate motor learning.Methods/design: A prospective, double-blind, randomized, controlled, analytical, clinical trial will be carried out. Eligible participants will be children with cerebral palsy classified on levels I, II and III of the Gross Motor Function Classification System between four and ten years of age. the participants will be randomly allocated to four groups: 1) gait training on a treadmill with placebo transcranial stimulation; 2) gait training on a treadmill with active transcranial stimulation; 3) mobility training with virtual reality and placebo transcranial stimulation; 4) mobility training with virtual reality and active transcranial stimulation. Transcranial direct current stimulation will be applied with the anodal electrode positioned in the region of the dominant hemisphere over C3, corresponding to the primary motor cortex, and the cathode positioned in the supraorbital region contralateral to the anode. A 1 mA current will be applied for 20 minutes. Treadmill training and mobility training with virtual reality will be performed in 30-minute sessions five times a week for two weeks (total of 10 sessions). Evaluations will be performed on four occasions: one week prior to the intervention; one week following the intervention; one month after the end of the intervention; and 3 months after the end of the intervention. the evaluations will involve three-dimensional gait analysis, analysis of cortex excitability (motor threshold and motor evoked potential), Six-Minute Walk Test, Timed Up-and-Go Test, Pediatric Evaluation Disability Inventory, Gross Motor Function Measure, Berg Balance Scale, stabilometry, maximum respiratory pressure and an effort test.Discussion: This paper offers a detailed description of a prospective, double-blind, randomized, controlled, analytical, clinical trial aimed at demonstrating the effect combining transcranial stimulation with treadmill and mobility training on functionality and primary cortex excitability in children with Cerebral Palsy classified on Gross Motor Function Classification System levels I, II and III. the results will be published and will contribute to evidence regarding the use of treadmill training on this population. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-10-11 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:35Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:35Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Bmc Pediatrics. London: Biomed Central Ltd, v. 13, 11 p., 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36877 http://dx.doi.org/10.1186/1471-2431-13-168 |
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1471-2431 |
dc.identifier.file.none.fl_str_mv |
WOS000327494300001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1186/1471-2431-13-168 |
dc.identifier.wos.none.fl_str_mv |
WOS:000327494300001 |
identifier_str_mv |
Bmc Pediatrics. London: Biomed Central Ltd, v. 13, 11 p., 2013. 1471-2431 WOS000327494300001.pdf 10.1186/1471-2431-13-168 WOS:000327494300001 |
url |
http://repositorio.unifesp.br/handle/11600/36877 http://dx.doi.org/10.1186/1471-2431-13-168 |
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eng |
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Biomed Central Ltd |
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Biomed Central Ltd |
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