Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects

Detalhes bibliográficos
Autor(a) principal: Barros, Elizabete Ribeiro [UNIFESP]
Data de Publicação: 2002
Outros Autores: Kasamatsu, Teresa Sayoko [UNIFESP], Ramalho, Ana Claudia Rebouças [UNIFESP], Hauache, Omar Magid [UNIFESP], Vieira, Jose Gilberto Henriques [UNIFESP], Lazaretti-Castro, Marise [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2002000800005
http://repositorio.unifesp.br/handle/11600/1480
Resumo: Osteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and femoral or lumbar spine BMD was detected. There was a positive association between lumbar spine BMD and weight (P<0.0001), height (P<0.0156), and body mass index (BMI) (P<0.0156), and a negative association with age at menarche (P<0.0026). There was also a positive association between femoral BMD and weight (P<0.0001), height (P<0.0001), and BMI (P<0.0001), and a negative correlation with family history for osteoporosis (P<0.041). There was no association between the presence of allele s and reduced BMD. We conclude that a family history of osteoporosis and age at menarche are factors that may influence bone mass in our population.
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spelling Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspectsCOLIA1Bone mineral densityRisk factorsPolymorphismOsteoporosisOsteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and femoral or lumbar spine BMD was detected. There was a positive association between lumbar spine BMD and weight (P<0.0001), height (P<0.0156), and body mass index (BMI) (P<0.0156), and a negative association with age at menarche (P<0.0026). There was also a positive association between femoral BMD and weight (P<0.0001), height (P<0.0001), and BMI (P<0.0001), and a negative correlation with family history for osteoporosis (P<0.041). There was no association between the presence of allele s and reduced BMD. We conclude that a family history of osteoporosis and age at menarche are factors that may influence bone mass in our population.Universidade Federal de São Paulo (UNIFESP) Setor de Doença Ósteo-Metabólica Disciplina de EndocrinologiaUniversidade Federal de São Paulo (UNIFESP) Laboratório de Endocrinologia Molecular Disciplina de EndocrinologiaFaculdade Baiana de Medicina e Saúde PúblicaUNIFESP, Setor de Doença Ósteo-Metabólica Disciplina de EndocrinologiaUNIFESP, Laboratório de Endocrinologia Molecular Disciplina de EndocrinologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Faculdade Baiana de Medicina e Saúde PúblicaBarros, Elizabete Ribeiro [UNIFESP]Kasamatsu, Teresa Sayoko [UNIFESP]Ramalho, Ana Claudia Rebouças [UNIFESP]Hauache, Omar Magid [UNIFESP]Vieira, Jose Gilberto Henriques [UNIFESP]Lazaretti-Castro, Marise [UNIFESP]2015-06-14T13:29:45Z2015-06-14T13:29:45Z2002-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion885-893application/pdfhttp://dx.doi.org/10.1590/S0100-879X2002000800005Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 8, p. 885-893, 2002.10.1590/S0100-879X2002000800005S0100-879X2002000800005.pdf0100-879XS0100-879X2002000800005http://repositorio.unifesp.br/handle/11600/1480WOS:000179079400005engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T17:42:31Zoai:repositorio.unifesp.br/:11600/1480Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T17:42:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
title Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
spellingShingle Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
Barros, Elizabete Ribeiro [UNIFESP]
COLIA1
Bone mineral density
Risk factors
Polymorphism
Osteoporosis
title_short Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
title_full Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
title_fullStr Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
title_full_unstemmed Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
title_sort Bone mineral density in young women of the city of São Paulo, Brazil: correlation with both collagen type I alpha 1 gene polymorphism and clinical aspects
author Barros, Elizabete Ribeiro [UNIFESP]
author_facet Barros, Elizabete Ribeiro [UNIFESP]
Kasamatsu, Teresa Sayoko [UNIFESP]
Ramalho, Ana Claudia Rebouças [UNIFESP]
Hauache, Omar Magid [UNIFESP]
Vieira, Jose Gilberto Henriques [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
author_role author
author2 Kasamatsu, Teresa Sayoko [UNIFESP]
Ramalho, Ana Claudia Rebouças [UNIFESP]
Hauache, Omar Magid [UNIFESP]
Vieira, Jose Gilberto Henriques [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Faculdade Baiana de Medicina e Saúde Pública
dc.contributor.author.fl_str_mv Barros, Elizabete Ribeiro [UNIFESP]
Kasamatsu, Teresa Sayoko [UNIFESP]
Ramalho, Ana Claudia Rebouças [UNIFESP]
Hauache, Omar Magid [UNIFESP]
Vieira, Jose Gilberto Henriques [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
dc.subject.por.fl_str_mv COLIA1
Bone mineral density
Risk factors
Polymorphism
Osteoporosis
topic COLIA1
Bone mineral density
Risk factors
Polymorphism
Osteoporosis
description Osteoporosis is a multifactorial disease with great impact on morbidity and mortality mainly in postmenopausal women. Although it is recognized that factors related to life-style and habits may influence bone mass formation leading to greater or lower bone mass, more than 85% of the variation in bone mineral density (BMD) is genetically determined. The collagen type I alpha 1 (COLIA1) gene is a possible risk factor for osteoporosis. We studied a population of 220 young women from the city of São Paulo, Brazil, with respect to BMD and its correlation with both COLIA1 genotype and clinical aspects. The distribution of COLIA1 genotype SS, Ss and ss in the population studied was 73.6, 24.1 and 2.3%, respectively. No association between these genotypes and femoral or lumbar spine BMD was detected. There was a positive association between lumbar spine BMD and weight (P<0.0001), height (P<0.0156), and body mass index (BMI) (P<0.0156), and a negative association with age at menarche (P<0.0026). There was also a positive association between femoral BMD and weight (P<0.0001), height (P<0.0001), and BMI (P<0.0001), and a negative correlation with family history for osteoporosis (P<0.041). There was no association between the presence of allele s and reduced BMD. We conclude that a family history of osteoporosis and age at menarche are factors that may influence bone mass in our population.
publishDate 2002
dc.date.none.fl_str_mv 2002-08-01
2015-06-14T13:29:45Z
2015-06-14T13:29:45Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2002000800005
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 8, p. 885-893, 2002.
10.1590/S0100-879X2002000800005
S0100-879X2002000800005.pdf
0100-879X
S0100-879X2002000800005
http://repositorio.unifesp.br/handle/11600/1480
WOS:000179079400005
url http://dx.doi.org/10.1590/S0100-879X2002000800005
http://repositorio.unifesp.br/handle/11600/1480
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 8, p. 885-893, 2002.
10.1590/S0100-879X2002000800005
S0100-879X2002000800005.pdf
0100-879X
S0100-879X2002000800005
WOS:000179079400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 885-893
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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