A glimpse on biological activities of tellurium compounds

Detalhes bibliográficos
Autor(a) principal: Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]
Data de Publicação: 2009
Outros Autores: Gouvea, Iuri Estrada [UNIFESP], Juliano, Luiz [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0001-37652009000300006
http://repositorio.unifesp.br/handle/11600/5205
Resumo: Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organic derivatives have been studied, leading to a set of interesting and promising applications. As an example, it can be highlighted the uses of alkali-metal tellurites and tellurates in microbiology, the antioxidant effects of organotellurides and diorganoditellurides and the immunomodulatory effects of the non-toxic inorganic tellurane, named AS-101, and the plethora of its uses. Inasmuch, the nascent applications of organic telluranes (organotelluranes) as protease inhibitors and its applications in disease models are the most recent contribution to the scenario of the biological effects and applications of tellurium and its compounds discussed in this manuscript.
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spelling A glimpse on biological activities of tellurium compoundsantitumoralsbiological applicationsenzyme inhibitorsorganotelluriumproteasestelluriumantitumoraisaplicações biológicasenzimas inibidorascompostos orgânicos de telúrioproteasestelúrioTellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organic derivatives have been studied, leading to a set of interesting and promising applications. As an example, it can be highlighted the uses of alkali-metal tellurites and tellurates in microbiology, the antioxidant effects of organotellurides and diorganoditellurides and the immunomodulatory effects of the non-toxic inorganic tellurane, named AS-101, and the plethora of its uses. Inasmuch, the nascent applications of organic telluranes (organotelluranes) as protease inhibitors and its applications in disease models are the most recent contribution to the scenario of the biological effects and applications of tellurium and its compounds discussed in this manuscript.O telúrio é um elemento não-essencial raro que vem sendo considerado tóxico, e o seu papel biológico é ainda pouco esclarecido. Apesar disso, os efeitos biológicos do telúrio elementar e de alguns derivados inorgânicos e orgânicos que têm sido estudados revelam um conjunto de aplicações diversificadas interessantes e promissoras. Como exemplo, pode-se destacar os usos de teluritos e teluratos de metais alcalinos em microbiologia, o efeito antioxidante de teluretos e diteluretos orgânicos, os efeitos imunomodulatórios e a diversidade de usos correlacionados a este efeito de uma telurana inorgânica denominada AS-101. Ademais, as aplicações de teluranas orgânicas (organoteluranas) como inibidoras de proteases e as aplicações em modelos de doenças compõem a mais recente contribuição ao cenário dos efeitos e aplicações biológicas do telúrio e seus compostos discutidas neste manuscrito.UNIFESP Departamento de Ciências Exatas e da TerraUNIFESP Departamento de BiofísicaUNIFESP, Depto. de Ciências Exatas e da TerraUNIFESP, Depto. de BiofísicaSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Academia Brasileira de CiênciasUniversidade Federal de São Paulo (UNIFESP)Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]Gouvea, Iuri Estrada [UNIFESP]Juliano, Luiz [UNIFESP]2015-06-14T13:41:07Z2015-06-14T13:41:07Z2009-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion393-407application/pdfhttp://dx.doi.org/10.1590/S0001-37652009000300006Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 393-407, 2009.10.1590/S0001-37652009000300006S0001-37652009000300006.pdf0001-3765S0001-37652009000300006http://repositorio.unifesp.br/handle/11600/5205WOS:000269462300006engAnais da Academia Brasileira de Ciênciasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T08:53:49Zoai:repositorio.unifesp.br/:11600/5205Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T08:53:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv A glimpse on biological activities of tellurium compounds
title A glimpse on biological activities of tellurium compounds
spellingShingle A glimpse on biological activities of tellurium compounds
Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]
antitumorals
biological applications
enzyme inhibitors
organotellurium
proteases
tellurium
antitumorais
aplicações biológicas
enzimas inibidoras
compostos orgânicos de telúrio
proteases
telúrio
title_short A glimpse on biological activities of tellurium compounds
title_full A glimpse on biological activities of tellurium compounds
title_fullStr A glimpse on biological activities of tellurium compounds
title_full_unstemmed A glimpse on biological activities of tellurium compounds
title_sort A glimpse on biological activities of tellurium compounds
author Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]
author_facet Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]
Gouvea, Iuri Estrada [UNIFESP]
Juliano, Luiz [UNIFESP]
author_role author
author2 Gouvea, Iuri Estrada [UNIFESP]
Juliano, Luiz [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Cunha, Rodrigo Luiz Oliveira Rodrigues [UNIFESP]
Gouvea, Iuri Estrada [UNIFESP]
Juliano, Luiz [UNIFESP]
dc.subject.por.fl_str_mv antitumorals
biological applications
enzyme inhibitors
organotellurium
proteases
tellurium
antitumorais
aplicações biológicas
enzimas inibidoras
compostos orgânicos de telúrio
proteases
telúrio
topic antitumorals
biological applications
enzyme inhibitors
organotellurium
proteases
tellurium
antitumorais
aplicações biológicas
enzimas inibidoras
compostos orgânicos de telúrio
proteases
telúrio
description Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and some of its inorganic and organic derivatives have been studied, leading to a set of interesting and promising applications. As an example, it can be highlighted the uses of alkali-metal tellurites and tellurates in microbiology, the antioxidant effects of organotellurides and diorganoditellurides and the immunomodulatory effects of the non-toxic inorganic tellurane, named AS-101, and the plethora of its uses. Inasmuch, the nascent applications of organic telluranes (organotelluranes) as protease inhibitors and its applications in disease models are the most recent contribution to the scenario of the biological effects and applications of tellurium and its compounds discussed in this manuscript.
publishDate 2009
dc.date.none.fl_str_mv 2009-09-01
2015-06-14T13:41:07Z
2015-06-14T13:41:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0001-37652009000300006
Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 393-407, 2009.
10.1590/S0001-37652009000300006
S0001-37652009000300006.pdf
0001-3765
S0001-37652009000300006
http://repositorio.unifesp.br/handle/11600/5205
WOS:000269462300006
url http://dx.doi.org/10.1590/S0001-37652009000300006
http://repositorio.unifesp.br/handle/11600/5205
identifier_str_mv Anais da Academia Brasileira de Ciências. Academia Brasileira de Ciências, v. 81, n. 3, p. 393-407, 2009.
10.1590/S0001-37652009000300006
S0001-37652009000300006.pdf
0001-3765
S0001-37652009000300006
WOS:000269462300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Anais da Academia Brasileira de Ciências
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 393-407
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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