Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1097/MPG.0000000000000224 http://repositorio.unifesp.br/handle/11600/37459 |
Resumo: | Objectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency. |
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Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipationchildconstipationfiberrandomized controlled trialObjectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency.Universidade Federal de São Paulo, Div Pediat Gastroenterol, São Paulo, BrazilSanta Casa São Paulo, Dept Pediat, Sch Med, BR-01234001 São Paulo, BrazilUniversidade Federal de São Paulo, Div Pediat Gastroenterol, São Paulo, BrazilWeb of ScienceSupport Produtos NutricionaisLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Santa Casa São PauloWeber, Thabata K. [UNIFESP]Toporovski, Mauro S.Tahan, Soraia [UNIFESP]Neufeld, Clarice B.Morais, Mauro B. de [UNIFESP]2016-01-24T14:35:20Z2016-01-24T14:35:20Z2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion297-302http://dx.doi.org/10.1097/MPG.0000000000000224Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014.10.1097/MPG.00000000000002240277-2116http://repositorio.unifesp.br/handle/11600/37459WOS:000333297300010engJournal of Pediatric Gastroenterology and Nutritioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T12:35:20Zoai:repositorio.unifesp.br/:11600/37459Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T12:35:20Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
title |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
spellingShingle |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation Weber, Thabata K. [UNIFESP] child constipation fiber randomized controlled trial |
title_short |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
title_full |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
title_fullStr |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
title_full_unstemmed |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
title_sort |
Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation |
author |
Weber, Thabata K. [UNIFESP] |
author_facet |
Weber, Thabata K. [UNIFESP] Toporovski, Mauro S. Tahan, Soraia [UNIFESP] Neufeld, Clarice B. Morais, Mauro B. de [UNIFESP] |
author_role |
author |
author2 |
Toporovski, Mauro S. Tahan, Soraia [UNIFESP] Neufeld, Clarice B. Morais, Mauro B. de [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Santa Casa São Paulo |
dc.contributor.author.fl_str_mv |
Weber, Thabata K. [UNIFESP] Toporovski, Mauro S. Tahan, Soraia [UNIFESP] Neufeld, Clarice B. Morais, Mauro B. de [UNIFESP] |
dc.subject.por.fl_str_mv |
child constipation fiber randomized controlled trial |
topic |
child constipation fiber randomized controlled trial |
description |
Objectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 2016-01-24T14:35:20Z 2016-01-24T14:35:20Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/MPG.0000000000000224 Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014. 10.1097/MPG.0000000000000224 0277-2116 http://repositorio.unifesp.br/handle/11600/37459 WOS:000333297300010 |
url |
http://dx.doi.org/10.1097/MPG.0000000000000224 http://repositorio.unifesp.br/handle/11600/37459 |
identifier_str_mv |
Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014. 10.1097/MPG.0000000000000224 0277-2116 WOS:000333297300010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Pediatric Gastroenterology and Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
297-302 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268382855299072 |