Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation

Detalhes bibliográficos
Autor(a) principal: Weber, Thabata K. [UNIFESP]
Data de Publicação: 2014
Outros Autores: Toporovski, Mauro S., Tahan, Soraia [UNIFESP], Neufeld, Clarice B., Morais, Mauro B. de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1097/MPG.0000000000000224
http://repositorio.unifesp.br/handle/11600/37459
Resumo: Objectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency.
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spelling Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipationchildconstipationfiberrandomized controlled trialObjectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency.Universidade Federal de São Paulo, Div Pediat Gastroenterol, São Paulo, BrazilSanta Casa São Paulo, Dept Pediat, Sch Med, BR-01234001 São Paulo, BrazilUniversidade Federal de São Paulo, Div Pediat Gastroenterol, São Paulo, BrazilWeb of ScienceSupport Produtos NutricionaisLippincott Williams & WilkinsUniversidade Federal de São Paulo (UNIFESP)Santa Casa São PauloWeber, Thabata K. [UNIFESP]Toporovski, Mauro S.Tahan, Soraia [UNIFESP]Neufeld, Clarice B.Morais, Mauro B. de [UNIFESP]2016-01-24T14:35:20Z2016-01-24T14:35:20Z2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion297-302http://dx.doi.org/10.1097/MPG.0000000000000224Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014.10.1097/MPG.00000000000002240277-2116http://repositorio.unifesp.br/handle/11600/37459WOS:000333297300010engJournal of Pediatric Gastroenterology and Nutritioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2016-01-24T12:35:20Zoai:repositorio.unifesp.br/:11600/37459Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652016-01-24T12:35:20Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
title Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
spellingShingle Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
Weber, Thabata K. [UNIFESP]
child
constipation
fiber
randomized controlled trial
title_short Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
title_full Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
title_fullStr Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
title_full_unstemmed Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
title_sort Dietary Fiber Mixture in Pediatric Patients With Controlled Chronic Constipation
author Weber, Thabata K. [UNIFESP]
author_facet Weber, Thabata K. [UNIFESP]
Toporovski, Mauro S.
Tahan, Soraia [UNIFESP]
Neufeld, Clarice B.
Morais, Mauro B. de [UNIFESP]
author_role author
author2 Toporovski, Mauro S.
Tahan, Soraia [UNIFESP]
Neufeld, Clarice B.
Morais, Mauro B. de [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Santa Casa São Paulo
dc.contributor.author.fl_str_mv Weber, Thabata K. [UNIFESP]
Toporovski, Mauro S.
Tahan, Soraia [UNIFESP]
Neufeld, Clarice B.
Morais, Mauro B. de [UNIFESP]
dc.subject.por.fl_str_mv child
constipation
fiber
randomized controlled trial
topic child
constipation
fiber
randomized controlled trial
description Objectives:The aim of the study was to test the clinical efficacy and effect on colonic transit time (CTT) of a dietary fiber mixture given to children with controlled chronic constipation (CC) after the withdrawal of stool softeners and enemas.Methods:This randomized, placebo-controlled, double-blind clinical trial involved 54 patients aged 4 to 12 years and had CC that was controlled by the use of low-dose stool softeners. the use of these softeners was discontinued when the patients were admitted to the clinical trial. the patients were randomized into 2 groups for the 4-week study period. One group received a dietary fiber mixture and the other group received a placebo (maltodextrin). the primary outcome was therapeutic failure (oral stool softeners or enemas was required to prescribe during the trial). Secondary outcomes included defecation frequency, stool consistency (measured using the Bristol Stool Form Scale), and CTT.Results:Therapeutic failure was observed in 34.6% (9/26) of the patients in the dietary fiber mixture group and in 35.7% (10/28) in the control group (P=0.933). the mean increase in daily bowel movements was 0.53 in the dietary fiber mixture group and 0.23 in the control group (P=0.014). the patients in the dietary fiber mixture group (60.0%) passed nonhardened stools more frequently than did those in the control group (16.7%, P=0.003). the CTT was similar for both groups.Conclusions:The fiber mixture did not prevent the suspension of stool softeners or lead to reduced CTT; however, the mixture promoted an increased frequency of defecation and an improvement in the stool consistency.
publishDate 2014
dc.date.none.fl_str_mv 2014-03-01
2016-01-24T14:35:20Z
2016-01-24T14:35:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1097/MPG.0000000000000224
Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014.
10.1097/MPG.0000000000000224
0277-2116
http://repositorio.unifesp.br/handle/11600/37459
WOS:000333297300010
url http://dx.doi.org/10.1097/MPG.0000000000000224
http://repositorio.unifesp.br/handle/11600/37459
identifier_str_mv Journal of Pediatric Gastroenterology and Nutrition. Philadelphia: Lippincott Williams & Wilkins, v. 58, n. 3, p. 297-302, 2014.
10.1097/MPG.0000000000000224
0277-2116
WOS:000333297300010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Pediatric Gastroenterology and Nutrition
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 297-302
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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