Comparison between endoscopic brush cytology performed before and after biliary stricture dilation for cancer detection

• Autor(a) principal: Ornellas, Laura Cotta
• Data de Publicação: 2006
• Outros Autores: Santos, Gilda Da Cunha [UNIFESP], Nakao, Frank Shigueo, Ferrari, Angelo Paulo [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-28032006000100007; http://repositorio.unifesp.br/handle/11600/2960
• topic: Cytological techniques; Balloon dilatation; Cholangiopancreatography, endoscopic retrograde; Bile duct neoplasms; Pancreatic ducts; Técnicas citológicas; Dilatação com balão; Pancreatocolangiografia retrógrada endoscópica; Neoplasia das vias biliares; Ductos pancreáticos

BACKGROUND: Confirmation of malignancy within biliary strictures is endoscopically challenging. Dilation of strictures has been reported to enhance cytological diagnosis. AIM: To compare brush cytology results before and after biliary stricture dilation. PATIENTS AND METHODS: Patients with extra-hepatic biliary stricture at endoscopic retrograde cholangiopancreatography were included in the study. Brushing was performed before and immediately after dilation using a 10 Fr dilating catheter. Cytology samples were classified as: negative for malignancy, presence of atypical cells, insufficient material, suspicious for malignancy or positive for malignancy. Final diagnosis was established by surgery, biopsy or follow-up. RESULTS: Biliary brush cytology was performed in 50 patients, with an overall sensitivity of 40% and 27.5%, before and after dilation, respectively. The combination of results increased cancer detection rate to 45%. There were 5/50 (10%) minor complications and one death related to the procedure. CONCLUSIONS: Brush cytology performed before biliary stricture dilation has a similar cancer detection rate to that following dilation, although the combination of results enhances sensitivity.