Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.jneuroim.2012.03.012 http://repositorio.unifesp.br/handle/11600/34995 |
Resumo: | Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved. |
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Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's diseaseAlzheimer's diseaseInterleukin-1 betaPolymorphismsHaplotypesReceptor antagonistOur study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved.USC, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Morfol, Disciplina Genet, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Ambulatorio Neurol Comportament, São Paulo, BrazilFac Med Marilia FAMEMA, Hemoctr, Disciplina Genet, São Paulo, BrazilFac Med Sao Jose do Rio Preto, Nucleo Pesquisa Bioquim & Biol Mol, São Paulo, BrazilUniv Marilia UNIMAR, Fac Med, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Dept Morfol, Disciplina Genet, São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Ambulatorio Neurol Comportament, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade do Sagrado Coracao de BauruConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Faculdade de Medicina de Marilia (FAMEMA)FAPESP: 06/07240-3FAPESP: 09/15857-9FAPESP: 04/15273-3Elsevier B.V.USCUniversidade Federal de São Paulo (UNIFESP)Fac Med Marilia FAMEMAFac Med Sao Jose do Rio PretoUniv Marilia UNIMARPayão, Spencer Luiz Marques [UNIFESP]Gonçalves, Gisela MoraesLábio, Roger Willian deHoriguchi, LieMizumoto, IgorRasmussen, Lucas Trevizani [UNIFESP]Pinhel, Marcela Augusta de SouzaSouza, Dorotéia Rossi SilvaBechara, Marcelo DibChen, Elizabeth Suchi [UNIFESP]Mazzotti, Diego Robles [UNIFESP]Bertolucci, Paulo Henrique Ferreira [UNIFESP]Smith, Marilia de Arruda Cardoso [UNIFESP]2016-01-24T14:27:22Z2016-01-24T14:27:22Z2012-06-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion59-62application/pdfhttp://dx.doi.org/10.1016/j.jneuroim.2012.03.012Journal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 247, n. 1-2, p. 59-62, 2012.10.1016/j.jneuroim.2012.03.012WOS000304792900008.pdf0165-5728http://repositorio.unifesp.br/handle/11600/34995WOS:000304792900008engJournal of Neuroimmunologyinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T01:41:31Zoai:repositorio.unifesp.br/:11600/34995Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T01:41:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| title |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| spellingShingle |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease Payão, Spencer Luiz Marques [UNIFESP] Alzheimer's disease Interleukin-1 beta Polymorphisms Haplotypes Receptor antagonist |
| title_short |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| title_full |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| title_fullStr |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| title_full_unstemmed |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| title_sort |
Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease |
| author |
Payão, Spencer Luiz Marques [UNIFESP] |
| author_facet |
Payão, Spencer Luiz Marques [UNIFESP] Gonçalves, Gisela Moraes Lábio, Roger Willian de Horiguchi, Lie Mizumoto, Igor Rasmussen, Lucas Trevizani [UNIFESP] Pinhel, Marcela Augusta de Souza Souza, Dorotéia Rossi Silva Bechara, Marcelo Dib Chen, Elizabeth Suchi [UNIFESP] Mazzotti, Diego Robles [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] |
| author_role |
author |
| author2 |
Gonçalves, Gisela Moraes Lábio, Roger Willian de Horiguchi, Lie Mizumoto, Igor Rasmussen, Lucas Trevizani [UNIFESP] Pinhel, Marcela Augusta de Souza Souza, Dorotéia Rossi Silva Bechara, Marcelo Dib Chen, Elizabeth Suchi [UNIFESP] Mazzotti, Diego Robles [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
USC Universidade Federal de São Paulo (UNIFESP) Fac Med Marilia FAMEMA Fac Med Sao Jose do Rio Preto Univ Marilia UNIMAR |
| dc.contributor.author.fl_str_mv |
Payão, Spencer Luiz Marques [UNIFESP] Gonçalves, Gisela Moraes Lábio, Roger Willian de Horiguchi, Lie Mizumoto, Igor Rasmussen, Lucas Trevizani [UNIFESP] Pinhel, Marcela Augusta de Souza Souza, Dorotéia Rossi Silva Bechara, Marcelo Dib Chen, Elizabeth Suchi [UNIFESP] Mazzotti, Diego Robles [UNIFESP] Bertolucci, Paulo Henrique Ferreira [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] |
| dc.subject.por.fl_str_mv |
Alzheimer's disease Interleukin-1 beta Polymorphisms Haplotypes Receptor antagonist |
| topic |
Alzheimer's disease Interleukin-1 beta Polymorphisms Haplotypes Receptor antagonist |
| description |
Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-06-15 2016-01-24T14:27:22Z 2016-01-24T14:27:22Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jneuroim.2012.03.012 Journal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 247, n. 1-2, p. 59-62, 2012. 10.1016/j.jneuroim.2012.03.012 WOS000304792900008.pdf 0165-5728 http://repositorio.unifesp.br/handle/11600/34995 WOS:000304792900008 |
| url |
http://dx.doi.org/10.1016/j.jneuroim.2012.03.012 http://repositorio.unifesp.br/handle/11600/34995 |
| identifier_str_mv |
Journal of Neuroimmunology. Amsterdam: Elsevier B.V., v. 247, n. 1-2, p. 59-62, 2012. 10.1016/j.jneuroim.2012.03.012 WOS000304792900008.pdf 0165-5728 WOS:000304792900008 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Neuroimmunology |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
| dc.format.none.fl_str_mv |
59-62 application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268307817103360 |