From yeast killer toxins to antibiobodies and beyond

Detalhes bibliográficos
Autor(a) principal: Magliani, Walter
Data de Publicação: 2008
Outros Autores: Conti, Stefania, Travassos, Luiz R. [UNIFESP], Polonelli, Luciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x
http://repositorio.unifesp.br/handle/11600/30984
Resumo: Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.
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spelling From yeast killer toxins to antibiobodies and beyondantibiobodieskiller peptideskiller toxinsmicrobicidal antibodiesmicrobicidal peptidesAntibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.Univ Parma, Sez Microbiol, Dipartimento Patol & Med Lab, I-43100 Parma, ItalyUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Unidade Oncol Expt, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Unidade Oncol Expt, São Paulo, BrazilWeb of ScienceIstituto Superiore di SanitaWiley-BlackwellUniv ParmaUniversidade Federal de São Paulo (UNIFESP)Magliani, WalterConti, StefaniaTravassos, Luiz R. [UNIFESP]Polonelli, Luciano2016-01-24T13:51:49Z2016-01-24T13:51:49Z2008-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1-8http://dx.doi.org/10.1111/j.1574-6968.2008.01340.xFems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008.10.1111/j.1574-6968.2008.01340.x0378-1097http://repositorio.unifesp.br/handle/11600/30984WOS:000259524600001engFems Microbiology Lettersinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-03-27T16:19:31Zoai:repositorio.unifesp.br/:11600/30984Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-27T16:19:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv From yeast killer toxins to antibiobodies and beyond
title From yeast killer toxins to antibiobodies and beyond
spellingShingle From yeast killer toxins to antibiobodies and beyond
Magliani, Walter
antibiobodies
killer peptides
killer toxins
microbicidal antibodies
microbicidal peptides
title_short From yeast killer toxins to antibiobodies and beyond
title_full From yeast killer toxins to antibiobodies and beyond
title_fullStr From yeast killer toxins to antibiobodies and beyond
title_full_unstemmed From yeast killer toxins to antibiobodies and beyond
title_sort From yeast killer toxins to antibiobodies and beyond
author Magliani, Walter
author_facet Magliani, Walter
Conti, Stefania
Travassos, Luiz R. [UNIFESP]
Polonelli, Luciano
author_role author
author2 Conti, Stefania
Travassos, Luiz R. [UNIFESP]
Polonelli, Luciano
author2_role author
author
author
dc.contributor.none.fl_str_mv Univ Parma
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Magliani, Walter
Conti, Stefania
Travassos, Luiz R. [UNIFESP]
Polonelli, Luciano
dc.subject.por.fl_str_mv antibiobodies
killer peptides
killer toxins
microbicidal antibodies
microbicidal peptides
topic antibiobodies
killer peptides
killer toxins
microbicidal antibodies
microbicidal peptides
description Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.
publishDate 2008
dc.date.none.fl_str_mv 2008-11-01
2016-01-24T13:51:49Z
2016-01-24T13:51:49Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x
Fems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008.
10.1111/j.1574-6968.2008.01340.x
0378-1097
http://repositorio.unifesp.br/handle/11600/30984
WOS:000259524600001
url http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x
http://repositorio.unifesp.br/handle/11600/30984
identifier_str_mv Fems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008.
10.1111/j.1574-6968.2008.01340.x
0378-1097
WOS:000259524600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fems Microbiology Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 1-8
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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