From yeast killer toxins to antibiobodies and beyond
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x http://repositorio.unifesp.br/handle/11600/30984 |
Resumo: | Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed. |
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From yeast killer toxins to antibiobodies and beyondantibiobodieskiller peptideskiller toxinsmicrobicidal antibodiesmicrobicidal peptidesAntibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed.Univ Parma, Sez Microbiol, Dipartimento Patol & Med Lab, I-43100 Parma, ItalyUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Unidade Oncol Expt, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Imunol & Parasitol, Unidade Oncol Expt, São Paulo, BrazilWeb of ScienceIstituto Superiore di SanitaWiley-BlackwellUniv ParmaUniversidade Federal de São Paulo (UNIFESP)Magliani, WalterConti, StefaniaTravassos, Luiz R. [UNIFESP]Polonelli, Luciano2016-01-24T13:51:49Z2016-01-24T13:51:49Z2008-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1-8http://dx.doi.org/10.1111/j.1574-6968.2008.01340.xFems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008.10.1111/j.1574-6968.2008.01340.x0378-1097http://repositorio.unifesp.br/handle/11600/30984WOS:000259524600001engFems Microbiology Lettersinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-03-27T16:19:31Zoai:repositorio.unifesp.br/:11600/30984Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-27T16:19:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
From yeast killer toxins to antibiobodies and beyond |
title |
From yeast killer toxins to antibiobodies and beyond |
spellingShingle |
From yeast killer toxins to antibiobodies and beyond Magliani, Walter antibiobodies killer peptides killer toxins microbicidal antibodies microbicidal peptides |
title_short |
From yeast killer toxins to antibiobodies and beyond |
title_full |
From yeast killer toxins to antibiobodies and beyond |
title_fullStr |
From yeast killer toxins to antibiobodies and beyond |
title_full_unstemmed |
From yeast killer toxins to antibiobodies and beyond |
title_sort |
From yeast killer toxins to antibiobodies and beyond |
author |
Magliani, Walter |
author_facet |
Magliani, Walter Conti, Stefania Travassos, Luiz R. [UNIFESP] Polonelli, Luciano |
author_role |
author |
author2 |
Conti, Stefania Travassos, Luiz R. [UNIFESP] Polonelli, Luciano |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Univ Parma Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Magliani, Walter Conti, Stefania Travassos, Luiz R. [UNIFESP] Polonelli, Luciano |
dc.subject.por.fl_str_mv |
antibiobodies killer peptides killer toxins microbicidal antibodies microbicidal peptides |
topic |
antibiobodies killer peptides killer toxins microbicidal antibodies microbicidal peptides |
description |
Antibiobodies are paradigmatic of yeast killer toxin (KT)-like antibodies (KAbs) mimicking the antimicrobial activity of KTs in the frame of the yeast killer phenomenon. Polyclonal, monoclonal and recombinant anti-idiotypic antibiobodies (anti-idiotypic KAbs), internal images of a wide-spectrum KT produced by the yeast Pichia anomala (PaKT), have been produced by immunization with the idiotype of a PaKT-neutralizing monoclonal antibody. Anti-idiotypic KAbs showed microbicidal activity against eukaryotic and prokaryotic pathogenic agents through the interaction with specific KT receptors (KTRs), putatively constituted by beta-glucans. Natural KAbs have been found in animals and humans experimentally or naturally infected by KTR-bearing microorganisms. Recombinant KAb-derived synthetic killer peptides showed further antiviral and immunomodulatory activities. the perspectives of KAbs and killer peptides as potential sources of novel therapeutic agents, and of KTRs and idiotypes as vaccines against infectious diseases are discussed. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-11-01 2016-01-24T13:51:49Z 2016-01-24T13:51:49Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x Fems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008. 10.1111/j.1574-6968.2008.01340.x 0378-1097 http://repositorio.unifesp.br/handle/11600/30984 WOS:000259524600001 |
url |
http://dx.doi.org/10.1111/j.1574-6968.2008.01340.x http://repositorio.unifesp.br/handle/11600/30984 |
identifier_str_mv |
Fems Microbiology Letters. Malden: Wiley-Blackwell, v. 288, n. 1, p. 1-8, 2008. 10.1111/j.1574-6968.2008.01340.x 0378-1097 WOS:000259524600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fems Microbiology Letters |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
dc.format.none.fl_str_mv |
1-8 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268448138592256 |