Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium

Detalhes bibliográficos
Autor(a) principal: Prior, Pedro Luis [UNIFESP]
Data de Publicação: 2011
Outros Autores: Galduróz, José Carlos Fernandes [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.mehy.2011.05.017
http://repositorio.unifesp.br/handle/11600/33973
Resumo: It is known that the glutamatergic pathways are hyperfunctioning during alcohol withdrawal syndrome. It has been demonstrated that hyperfunctioning of this system causes a great damage to the superior cortical activity, the ability to concentrate and the control of impulses. Recent studies show that the cations zinc and magnesium modulate the glutamatergic function, reducing it to non-toxic levels, yet not reducing it to the point of depriving this neurotransmitter of its normal activity. New perspectives of treatment focus on the modulation of this system, having, as a result, reestablishment of impulse control abilities, damage prevention to the hippocampus and the amygdala and prevention of future relapses. (C) 2011 Elsevier B.V. All rights reserved.
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spelling Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesiumIt is known that the glutamatergic pathways are hyperfunctioning during alcohol withdrawal syndrome. It has been demonstrated that hyperfunctioning of this system causes a great damage to the superior cortical activity, the ability to concentrate and the control of impulses. Recent studies show that the cations zinc and magnesium modulate the glutamatergic function, reducing it to non-toxic levels, yet not reducing it to the point of depriving this neurotransmitter of its normal activity. New perspectives of treatment focus on the modulation of this system, having, as a result, reestablishment of impulse control abilities, damage prevention to the hippocampus and the amygdala and prevention of future relapses. (C) 2011 Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, BR-04024002 São Paulo, BrazilWeb of ScienceChurchill LivingstoneUniversidade Federal de São Paulo (UNIFESP)Prior, Pedro Luis [UNIFESP]Galduróz, José Carlos Fernandes [UNIFESP]2016-01-24T14:17:07Z2016-01-24T14:17:07Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion368-370application/pdfhttp://dx.doi.org/10.1016/j.mehy.2011.05.017Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 3, p. 368-370, 2011.10.1016/j.mehy.2011.05.017WOS000295183500014.pdf0306-9877http://repositorio.unifesp.br/handle/11600/33973WOS:000295183500014engMedical Hypothesesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T21:02:36Zoai:repositorio.unifesp.br/:11600/33973Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T21:02:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
title Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
spellingShingle Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
Prior, Pedro Luis [UNIFESP]
title_short Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
title_full Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
title_fullStr Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
title_full_unstemmed Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
title_sort Glutamatergic hyperfunctioning during alcohol withdrawal syndrome: Therapeutic perspective with zinc and magnesium
author Prior, Pedro Luis [UNIFESP]
author_facet Prior, Pedro Luis [UNIFESP]
Galduróz, José Carlos Fernandes [UNIFESP]
author_role author
author2 Galduróz, José Carlos Fernandes [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Prior, Pedro Luis [UNIFESP]
Galduróz, José Carlos Fernandes [UNIFESP]
description It is known that the glutamatergic pathways are hyperfunctioning during alcohol withdrawal syndrome. It has been demonstrated that hyperfunctioning of this system causes a great damage to the superior cortical activity, the ability to concentrate and the control of impulses. Recent studies show that the cations zinc and magnesium modulate the glutamatergic function, reducing it to non-toxic levels, yet not reducing it to the point of depriving this neurotransmitter of its normal activity. New perspectives of treatment focus on the modulation of this system, having, as a result, reestablishment of impulse control abilities, damage prevention to the hippocampus and the amygdala and prevention of future relapses. (C) 2011 Elsevier B.V. All rights reserved.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
2016-01-24T14:17:07Z
2016-01-24T14:17:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.mehy.2011.05.017
Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 3, p. 368-370, 2011.
10.1016/j.mehy.2011.05.017
WOS000295183500014.pdf
0306-9877
http://repositorio.unifesp.br/handle/11600/33973
WOS:000295183500014
url http://dx.doi.org/10.1016/j.mehy.2011.05.017
http://repositorio.unifesp.br/handle/11600/33973
identifier_str_mv Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 3, p. 368-370, 2011.
10.1016/j.mehy.2011.05.017
WOS000295183500014.pdf
0306-9877
WOS:000295183500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Hypotheses
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 368-370
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268274974654464

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