Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death

Detalhes bibliográficos
Autor(a) principal: Bezerra, Andreia Gomes [UNIFESP]
Data de Publicação: 2016
Outros Autores: Negri, Giuseppina [UNIFESP], Duarte-Almeida, Joaquim Mauricio, Smaili, Soraya Soubhi [UNIFESP], Carlini, Elisaldo Araujo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/49379
http://dx.doi.org/10.1590/S1679-45082016AO3386
Resumo: Objective: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae
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spelling Bezerra, Andreia Gomes [UNIFESP]Negri, Giuseppina [UNIFESP]Duarte-Almeida, Joaquim MauricioSmaili, Soraya Soubhi [UNIFESP]Carlini, Elisaldo Araujo [UNIFESP]2019-01-21T10:29:46Z2019-01-21T10:29:46Z2016Einstein-Sao Paulo. Sao paulo sp, v. 14, n. 1, p. 56-63, 2016.1679-4508http://repositorio.unifesp.br/handle/11600/49379http://dx.doi.org/10.1590/S1679-45082016AO3386S1679-45082016000100056.pdfS1679-4508201600010005610.1590/S1679-45082016AO3386WOS:000385715800012Objective: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (TurneraceaeT. diffusa), as well as its toxicity in astrocytes. Methods: Chemical analyses of hydroethanolic extract from powdered aerial parts of T. diffusa were carried out using HPLC-DAD-ESI-MS/MS. In vitro assays using astrocytes culture were performed to evaluate cell death. Results: Flavone-C, O-diglycosides, such as, luteolin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside, apigenin-8-C-[ 6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside and apigenin-7-O-6"-p-coumaroylglucoside were the main compounds found in this hydroethanolic extract. Concentration time-effect demonstrated the toxicity of this extract at a concentration of 1,000 mu g/mL in astrocyte culture, after 6 and 24 hours of incubation. Conclusion: In phytochemical analyses, important antioxidants (mainly flavonoids) were observed. T. diffusa extracts presented cytotoxic effect in high concentrations, leading to increased cell death in astrocyte culture.Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)Centro Brasileiro de Informacoes sobre Drogas Psicotropicas (CEBRID)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Universidade Federal de São Paulo, São Paulo, SP, BrasilUniversidade Federal de São João del-Rei, Divinópolis, MG, BrasilUniversidade Federal de São Paulo, Rua Napoleao de Barros 925, BR-04024002 Sao Paulo, SP, Brazil.Web of Science56-63engElsevier Science BvEinstein-Sao PauloCognition/Drug EffectsPlant Extracts/ToxicityProtective Agents/ToxicityAntioxidantsCell Death/Drug EffectsPerformance Liquid-ChromatographyQuadrupole Mass-SpectrometryUltraviolet Uv RadiationIn-Vitro ModelPhenolic-CompoundsElectrospray-IonizationAntioxidant PropertiesAcid-DerivativesOxidative StressQuality-ControlPhytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell deathAnálise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/493792021-10-05 22:12:43.459metadata only accessoai:repositorio.unifesp.br:11600/49379Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T01:12:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
dc.title.pt.fl_str_mv Análise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitos
title Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
spellingShingle Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
Bezerra, Andreia Gomes [UNIFESP]
Cognition/Drug Effects
Plant Extracts/Toxicity
Protective Agents/Toxicity
Antioxidants
Cell Death/Drug EffectsPerformance Liquid-Chromatography
Quadrupole Mass-Spectrometry
Ultraviolet Uv Radiation
In-Vitro Model
Phenolic-Compounds
Electrospray-Ionization
Antioxidant Properties
Acid-Derivatives
Oxidative Stress
Quality-Control
title_short Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
title_full Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
title_fullStr Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
title_full_unstemmed Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
title_sort Phytochemical analysis of hydroethanolic extract of turnera diffusa willd and evaluation of its effects on astrocyte cell death
author Bezerra, Andreia Gomes [UNIFESP]
author_facet Bezerra, Andreia Gomes [UNIFESP]
Negri, Giuseppina [UNIFESP]
Duarte-Almeida, Joaquim Mauricio
Smaili, Soraya Soubhi [UNIFESP]
Carlini, Elisaldo Araujo [UNIFESP]
author_role author
author2 Negri, Giuseppina [UNIFESP]
Duarte-Almeida, Joaquim Mauricio
Smaili, Soraya Soubhi [UNIFESP]
Carlini, Elisaldo Araujo [UNIFESP]
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, Andreia Gomes [UNIFESP]
Negri, Giuseppina [UNIFESP]
Duarte-Almeida, Joaquim Mauricio
Smaili, Soraya Soubhi [UNIFESP]
Carlini, Elisaldo Araujo [UNIFESP]
dc.subject.eng.fl_str_mv Cognition/Drug Effects
Plant Extracts/Toxicity
Protective Agents/Toxicity
Antioxidants
Cell Death/Drug EffectsPerformance Liquid-Chromatography
Quadrupole Mass-Spectrometry
Ultraviolet Uv Radiation
In-Vitro Model
Phenolic-Compounds
Electrospray-Ionization
Antioxidant Properties
Acid-Derivatives
Oxidative Stress
Quality-Control
topic Cognition/Drug Effects
Plant Extracts/Toxicity
Protective Agents/Toxicity
Antioxidants
Cell Death/Drug EffectsPerformance Liquid-Chromatography
Quadrupole Mass-Spectrometry
Ultraviolet Uv Radiation
In-Vitro Model
Phenolic-Compounds
Electrospray-Ionization
Antioxidant Properties
Acid-Derivatives
Oxidative Stress
Quality-Control
description Objective: To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-01-21T10:29:46Z
dc.date.available.fl_str_mv 2019-01-21T10:29:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Einstein-Sao Paulo. Sao paulo sp, v. 14, n. 1, p. 56-63, 2016.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/49379
http://dx.doi.org/10.1590/S1679-45082016AO3386
dc.identifier.issn.none.fl_str_mv 1679-4508
dc.identifier.file.none.fl_str_mv S1679-45082016000100056.pdf
dc.identifier.scielo.none.fl_str_mv S1679-45082016000100056
dc.identifier.doi.none.fl_str_mv 10.1590/S1679-45082016AO3386
dc.identifier.wos.none.fl_str_mv WOS:000385715800012
identifier_str_mv Einstein-Sao Paulo. Sao paulo sp, v. 14, n. 1, p. 56-63, 2016.
1679-4508
S1679-45082016000100056.pdf
S1679-45082016000100056
10.1590/S1679-45082016AO3386
WOS:000385715800012
url http://repositorio.unifesp.br/handle/11600/49379
http://dx.doi.org/10.1590/S1679-45082016AO3386
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Einstein-Sao Paulo
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 56-63
dc.publisher.none.fl_str_mv Elsevier Science Bv
publisher.none.fl_str_mv Elsevier Science Bv
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1802764137139273728

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