Short and long term impact of adenotonsillectomy on the immune system

Detalhes bibliográficos
Autor(a) principal: Santos, Fabio Pires [UNIFESP]
Data de Publicação: 2013
Outros Autores: Weber, Raimar, Fortes, Bibiana Callegaro, Nagata Pignatari, Shirley Shizue [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.5935/1808-8694.20130006
http://repositorio.unifesp.br/handle/11600/35760
Resumo: Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.
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spelling Short and long term impact of adenotonsillectomy on the immune systemRepercussão da adenotonsilectomia sobre o sistema imune a curto e longo prazoadenoidectomychildimmune systemPalatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.UNIFESP EPM, Otol & Ear Surg Serv, São Paulo, BrazilProf Edmundo Vasconcelos Hosp, ENT Clin, Brazilian ENT HNS Assoc ENT, Moema, SP, BrazilFMUSP, São Paulo, BrazilProf Edmund Vasconcelos Hosp, ENT Clin, Moema, SP, BrazilUNIFESP EPM, São Paulo, BrazilBrazilian ENT HNS Assoc, São Paulo, BrazilProf Edmundo Vasconcelos Hosp, ENT Clin, UNIFESP EPM ENT, Dept ENT, Moema, SP, BrazilProf Edmundo Vasconcelos Hosp, ENT Clin, Moema, SP, BrazilUNIFESP EPM, Otol & Ear Surg Serv, São Paulo, BrazilUNIFESP EPM, São Paulo, BrazilProf Edmundo Vasconcelos Hosp, ENT Clin, UNIFESP EPM ENT, Dept ENT, Moema, SP, BrazilWeb of ScienceAssoc Brasileira Otorrinolaringologia & Cirurgia CervicofacialUniversidade Federal de São Paulo (UNIFESP)Prof Edmundo Vasconcelos HospUniversidade de São Paulo (USP)Prof Edmund Vasconcelos HospBrazilian ENT HNS AssocSantos, Fabio Pires [UNIFESP]Weber, RaimarFortes, Bibiana CallegaroNagata Pignatari, Shirley Shizue [UNIFESP]2016-01-24T14:30:58Z2016-01-24T14:30:58Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion28-34application/pdfhttp://dx.doi.org/10.5935/1808-8694.20130006Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.10.5935/1808-8694.20130006S1808-86942013000100006.pdf1808-8694S1808-86942013000100006http://repositorio.unifesp.br/handle/11600/35760WOS:000315660800006engBrazilian Journal of Otorhinolaryngologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T17:43:07Zoai:repositorio.unifesp.br/:11600/35760Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T17:43:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Short and long term impact of adenotonsillectomy on the immune system
Repercussão da adenotonsilectomia sobre o sistema imune a curto e longo prazo
title Short and long term impact of adenotonsillectomy on the immune system
spellingShingle Short and long term impact of adenotonsillectomy on the immune system
Santos, Fabio Pires [UNIFESP]
adenoidectomy
child
immune system
title_short Short and long term impact of adenotonsillectomy on the immune system
title_full Short and long term impact of adenotonsillectomy on the immune system
title_fullStr Short and long term impact of adenotonsillectomy on the immune system
title_full_unstemmed Short and long term impact of adenotonsillectomy on the immune system
title_sort Short and long term impact of adenotonsillectomy on the immune system
author Santos, Fabio Pires [UNIFESP]
author_facet Santos, Fabio Pires [UNIFESP]
Weber, Raimar
Fortes, Bibiana Callegaro
Nagata Pignatari, Shirley Shizue [UNIFESP]
author_role author
author2 Weber, Raimar
Fortes, Bibiana Callegaro
Nagata Pignatari, Shirley Shizue [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Prof Edmundo Vasconcelos Hosp
Universidade de São Paulo (USP)
Prof Edmund Vasconcelos Hosp
Brazilian ENT HNS Assoc
dc.contributor.author.fl_str_mv Santos, Fabio Pires [UNIFESP]
Weber, Raimar
Fortes, Bibiana Callegaro
Nagata Pignatari, Shirley Shizue [UNIFESP]
dc.subject.por.fl_str_mv adenoidectomy
child
immune system
topic adenoidectomy
child
immune system
description Palatine and pharyngeal tonsils are immune reactive lymphoid organs that manifest specific antibodies and B/T-cell activity to respond to a variety of antigens. They perform humoral and cellular immune functions. the possible effects of adenotonsillectomy upon the immune system remain controversial.Objective: To study the short and long-term impacts of tonsillectomy upon the cellular and humoral immunity of children.Method: This longitudinal prospective study included 29 children referred to adenotonsillectomy for adenotonsillar hypertrophy. Serum IgA, IgM, and IgG and lymphocyte counts were analyzed at three points in time: before surgery, 1-2 month's after surgery (short term), and 12-14 months after surgery (long term).Results: TCD4+ cell counts were significantly increased shortly after surgery. IgA and IgG values were significantly reduced in the long run, but were within normal ranges for this age group.Conclusion: 'This study indicated that adenotonsillectomy does not pose negative short or long term impacts upon the cellular and humoral immunity of children submitted to the procedure.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2016-01-24T14:30:58Z
2016-01-24T14:30:58Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/1808-8694.20130006
Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.
10.5935/1808-8694.20130006
S1808-86942013000100006.pdf
1808-8694
S1808-86942013000100006
http://repositorio.unifesp.br/handle/11600/35760
WOS:000315660800006
url http://dx.doi.org/10.5935/1808-8694.20130006
http://repositorio.unifesp.br/handle/11600/35760
identifier_str_mv Brazilian Journal of Otorhinolaryngology. São Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 79, n. 1, p. 28-34, 2013.
10.5935/1808-8694.20130006
S1808-86942013000100006.pdf
1808-8694
S1808-86942013000100006
WOS:000315660800006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Otorhinolaryngology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28-34
application/pdf
dc.publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
publisher.none.fl_str_mv Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268416072089600

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