TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/55833 http://dx.doi.org/10.1038/s41598-017-08299-x |
Resumo: | Malaria-associate pregnancy has a signifcant impact on infant morbidity and mortality. The detrimental efects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the efect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65GFP infection model. We observed that activation of the innate immune system by parasites leads to PM due to local infammation. We identifed TLR4 activation as the main pathway involved in the infammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-infammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe infammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus. |
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Barboza, Renato [UNIFESP]Lima, Flavia AfonsoReis, Aramys SilvaMurillo, Oscar JavierPeixoto, Erika Paula MachadoBandeira, Carla LeticiaFotoran, Wesley LuzettiSardinha, Luis RobertoWunderlich, GerhardBevilacqua, EstelaD'Imperio Lima, Maria ReginaAlvarez, Jose MariaMaranhao Costa, Fabio TrindadeGoncalves, Ligia AntunesEpiphanio, SabrinaMarinho, Claudio Romero Farias2020-07-20T16:31:16Z2020-07-20T16:31:16Z2018Scientific Reports. London, v. 7 2018.2045-2322https://repositorio.unifesp.br/handle/11600/55833http://dx.doi.org/10.1038/s41598-017-08299-xWOS000426652400004a.pdf10.1038/s41598-017-08299-xWOS:000426652400004aMalaria-associate pregnancy has a signifcant impact on infant morbidity and mortality. The detrimental efects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the efect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65GFP infection model. We observed that activation of the innate immune system by parasites leads to PM due to local infammation. We identifed TLR4 activation as the main pathway involved in the infammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-infammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe infammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus.Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilUniv Sao Paulo, Dept Biol Celular & Desenvolvimento, Sao Paulo, BrazilUniv Estadual Campinas, Inst Biol, Dept Genet Evolucao & Bioagentes, Campinas, SP, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, BrazilUniv Sao aulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Ciencias Biol, Diadema, BrazilWeb of ScienceengNature Publishing GroupScientific ReportsTLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondonv. 8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000426652400004a.pdfapplication/pdf10532894${dspace.ui.url}/bitstream/11600/55833/1/WOS000426652400004a.pdf04bfa25993020f0b28870c6493e4c0adMD51open accessTEXTWOS000426652400004a.pdf.txtWOS000426652400004a.pdf.txtExtracted texttext/plain51824${dspace.ui.url}/bitstream/11600/55833/8/WOS000426652400004a.pdf.txt36bc4de4e295ae809ce126c23aa83ca9MD58open accessTHUMBNAILWOS000426652400004a.pdf.jpgWOS000426652400004a.pdf.jpgIM Thumbnailimage/jpeg7565${dspace.ui.url}/bitstream/11600/55833/10/WOS000426652400004a.pdf.jpg55eb1cf00e348a29be4eb4370e0e46a2MD510open access11600/558332023-06-05 19:20:47.903open accessoai:repositorio.unifesp.br:11600/55833Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:20:47Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
title |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
spellingShingle |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) Barboza, Renato [UNIFESP] |
title_short |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
title_full |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
title_fullStr |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
title_full_unstemmed |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
title_sort |
TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017) |
author |
Barboza, Renato [UNIFESP] |
author_facet |
Barboza, Renato [UNIFESP] Lima, Flavia Afonso Reis, Aramys Silva Murillo, Oscar Javier Peixoto, Erika Paula Machado Bandeira, Carla Leticia Fotoran, Wesley Luzetti Sardinha, Luis Roberto Wunderlich, Gerhard Bevilacqua, Estela D'Imperio Lima, Maria Regina Alvarez, Jose Maria Maranhao Costa, Fabio Trindade Goncalves, Ligia Antunes Epiphanio, Sabrina Marinho, Claudio Romero Farias |
author_role |
author |
author2 |
Lima, Flavia Afonso Reis, Aramys Silva Murillo, Oscar Javier Peixoto, Erika Paula Machado Bandeira, Carla Leticia Fotoran, Wesley Luzetti Sardinha, Luis Roberto Wunderlich, Gerhard Bevilacqua, Estela D'Imperio Lima, Maria Regina Alvarez, Jose Maria Maranhao Costa, Fabio Trindade Goncalves, Ligia Antunes Epiphanio, Sabrina Marinho, Claudio Romero Farias |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Barboza, Renato [UNIFESP] Lima, Flavia Afonso Reis, Aramys Silva Murillo, Oscar Javier Peixoto, Erika Paula Machado Bandeira, Carla Leticia Fotoran, Wesley Luzetti Sardinha, Luis Roberto Wunderlich, Gerhard Bevilacqua, Estela D'Imperio Lima, Maria Regina Alvarez, Jose Maria Maranhao Costa, Fabio Trindade Goncalves, Ligia Antunes Epiphanio, Sabrina Marinho, Claudio Romero Farias |
description |
Malaria-associate pregnancy has a signifcant impact on infant morbidity and mortality. The detrimental efects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the efect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65GFP infection model. We observed that activation of the innate immune system by parasites leads to PM due to local infammation. We identifed TLR4 activation as the main pathway involved in the infammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-infammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe infammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-20T16:31:16Z |
dc.date.available.fl_str_mv |
2020-07-20T16:31:16Z |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Scientific Reports. London, v. 7 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/55833 http://dx.doi.org/10.1038/s41598-017-08299-x |
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2045-2322 |
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WOS000426652400004a.pdf |
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10.1038/s41598-017-08299-x |
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WOS:000426652400004a |
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Scientific Reports. London, v. 7 2018. 2045-2322 WOS000426652400004a.pdf 10.1038/s41598-017-08299-x WOS:000426652400004a |
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