Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination

Detalhes bibliográficos
Autor(a) principal: Miotto Junior, Ari [UNIFESP]
Data de Publicação: 2004
Outros Autores: Srougi, Miguel [UNIFESP], Brito, George A. de [UNIFESP], Leite, Kátia Ramos Moreira [UNIFESP], Nesrallah, Adriano J. [UNIFESP], Ortiz, Valdemar [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1677-55382004000200004
http://repositorio.unifesp.br/handle/11600/2055
Resumo: OBJECTIVES: The risks of identifying prostate cancer (PCa) in patients with serum total PSA (tPSA) between 4 and 10 ng/dl are between 25 and 35%. There are no data in Brazil showing the incidence of disease when all variables for PSA assessment are considered altogether, specifically tPSA, free fraction, PSA velocity and PSA stratified by age. The objective in this work was to define the incidence of disease in a population of men with abnormal values of PSA variables and normal digital rectal examination. MATERIALS AND METHODS: Between 1998 and 2003, 273 prostate biopsies were performed by the same radiologist and analyzed by the same pathologist. All patients had a normal digital rectal examination and biopsy had been indicated due to tPSA above 4 ng/dl or free-to-total PSA ratio (F/T PSA) below 15% or PSA velocity higher than 25% per year or a PSA level regarded as high for the age range. The relationship between these parameters and the positivity for prostate caner was determined. RESULTS: Patients' mean age was 63.8 years, and PCa was identified in 135 cases (49.5%). The incidence of PCa, related to unitary variations in tPSA, ranged from the limits of 33 to 80%, respectively, in tPSA < 3 and PSA between 15.1 to 20. When the other PSA parameters were assessed (free PSA, PSA according to age, rise velocity) PCa was detected in more than 25.3% of cases. CONCLUSION: When patients with normal digital rectal examination are selected for prostate biopsy due to tPSA levels above 4 or F/T PSA ratio lower than 15% or PSA velocity higher than 25% per year or high PSA for the age range, the incidence of PCa is quite higher than that observed in a population selected exclusively with basis on total PSA value.
id UFSP_9cdeb8a5b5bc2f019b31d94201e46d15
oai_identifier_str oai:repositorio.unifesp.br/:11600/2055
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examinationprostatic neoplasmsdiagnosisprostate-specific antigenbiopsyOBJECTIVES: The risks of identifying prostate cancer (PCa) in patients with serum total PSA (tPSA) between 4 and 10 ng/dl are between 25 and 35%. There are no data in Brazil showing the incidence of disease when all variables for PSA assessment are considered altogether, specifically tPSA, free fraction, PSA velocity and PSA stratified by age. The objective in this work was to define the incidence of disease in a population of men with abnormal values of PSA variables and normal digital rectal examination. MATERIALS AND METHODS: Between 1998 and 2003, 273 prostate biopsies were performed by the same radiologist and analyzed by the same pathologist. All patients had a normal digital rectal examination and biopsy had been indicated due to tPSA above 4 ng/dl or free-to-total PSA ratio (F/T PSA) below 15% or PSA velocity higher than 25% per year or a PSA level regarded as high for the age range. The relationship between these parameters and the positivity for prostate caner was determined. RESULTS: Patients' mean age was 63.8 years, and PCa was identified in 135 cases (49.5%). The incidence of PCa, related to unitary variations in tPSA, ranged from the limits of 33 to 80%, respectively, in tPSA < 3 and PSA between 15.1 to 20. When the other PSA parameters were assessed (free PSA, PSA according to age, rise velocity) PCa was detected in more than 25.3% of cases. CONCLUSION: When patients with normal digital rectal examination are selected for prostate biopsy due to tPSA levels above 4 or F/T PSA ratio lower than 15% or PSA velocity higher than 25% per year or high PSA for the age range, the incidence of PCa is quite higher than that observed in a population selected exclusively with basis on total PSA value.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of UrologyUNIFESP, EPM, Division of UrologySciELOSociedade Brasileira de UrologiaUniversidade Federal de São Paulo (UNIFESP)Miotto Junior, Ari [UNIFESP]Srougi, Miguel [UNIFESP]Brito, George A. de [UNIFESP]Leite, Kátia Ramos Moreira [UNIFESP]Nesrallah, Adriano J. [UNIFESP]Ortiz, Valdemar [UNIFESP]2015-06-14T13:30:21Z2015-06-14T13:30:21Z2004-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion109-113application/pdfhttp://dx.doi.org/10.1590/S1677-55382004000200004International braz j urol. Sociedade Brasileira de Urologia, v. 30, n. 2, p. 109-113, 2004.10.1590/S1677-55382004000200004S1677-55382004000200004.pdf1677-5538S1677-55382004000200004http://repositorio.unifesp.br/handle/11600/2055engInternational braz j urolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T06:38:22Zoai:repositorio.unifesp.br/:11600/2055Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T06:38:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
title Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
spellingShingle Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
Miotto Junior, Ari [UNIFESP]
prostatic neoplasms
diagnosis
prostate-specific antigen
biopsy
title_short Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
title_full Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
title_fullStr Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
title_full_unstemmed Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
title_sort Value of various PSA parameters for diagnosing prostate cancer in men with normal digital rectal examination
author Miotto Junior, Ari [UNIFESP]
author_facet Miotto Junior, Ari [UNIFESP]
Srougi, Miguel [UNIFESP]
Brito, George A. de [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Adriano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
author_role author
author2 Srougi, Miguel [UNIFESP]
Brito, George A. de [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Adriano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Miotto Junior, Ari [UNIFESP]
Srougi, Miguel [UNIFESP]
Brito, George A. de [UNIFESP]
Leite, Kátia Ramos Moreira [UNIFESP]
Nesrallah, Adriano J. [UNIFESP]
Ortiz, Valdemar [UNIFESP]
dc.subject.por.fl_str_mv prostatic neoplasms
diagnosis
prostate-specific antigen
biopsy
topic prostatic neoplasms
diagnosis
prostate-specific antigen
biopsy
description OBJECTIVES: The risks of identifying prostate cancer (PCa) in patients with serum total PSA (tPSA) between 4 and 10 ng/dl are between 25 and 35%. There are no data in Brazil showing the incidence of disease when all variables for PSA assessment are considered altogether, specifically tPSA, free fraction, PSA velocity and PSA stratified by age. The objective in this work was to define the incidence of disease in a population of men with abnormal values of PSA variables and normal digital rectal examination. MATERIALS AND METHODS: Between 1998 and 2003, 273 prostate biopsies were performed by the same radiologist and analyzed by the same pathologist. All patients had a normal digital rectal examination and biopsy had been indicated due to tPSA above 4 ng/dl or free-to-total PSA ratio (F/T PSA) below 15% or PSA velocity higher than 25% per year or a PSA level regarded as high for the age range. The relationship between these parameters and the positivity for prostate caner was determined. RESULTS: Patients' mean age was 63.8 years, and PCa was identified in 135 cases (49.5%). The incidence of PCa, related to unitary variations in tPSA, ranged from the limits of 33 to 80%, respectively, in tPSA < 3 and PSA between 15.1 to 20. When the other PSA parameters were assessed (free PSA, PSA according to age, rise velocity) PCa was detected in more than 25.3% of cases. CONCLUSION: When patients with normal digital rectal examination are selected for prostate biopsy due to tPSA levels above 4 or F/T PSA ratio lower than 15% or PSA velocity higher than 25% per year or high PSA for the age range, the incidence of PCa is quite higher than that observed in a population selected exclusively with basis on total PSA value.
publishDate 2004
dc.date.none.fl_str_mv 2004-04-01
2015-06-14T13:30:21Z
2015-06-14T13:30:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1677-55382004000200004
International braz j urol. Sociedade Brasileira de Urologia, v. 30, n. 2, p. 109-113, 2004.
10.1590/S1677-55382004000200004
S1677-55382004000200004.pdf
1677-5538
S1677-55382004000200004
http://repositorio.unifesp.br/handle/11600/2055
url http://dx.doi.org/10.1590/S1677-55382004000200004
http://repositorio.unifesp.br/handle/11600/2055
identifier_str_mv International braz j urol. Sociedade Brasileira de Urologia, v. 30, n. 2, p. 109-113, 2004.
10.1590/S1677-55382004000200004
S1677-55382004000200004.pdf
1677-5538
S1677-55382004000200004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International braz j urol
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 109-113
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268461052854272