Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit

Detalhes bibliográficos
Autor(a) principal: Moreira, Marina [UNIFESP]
Data de Publicação: 2007
Outros Autores: Freitas, Marise Reis de [UNIFESP], Martins, Sinaida Teixeira [UNIFESP], Castelo Filho, Adauto [UNIFESP], Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000q81b
Texto Completo: http://dx.doi.org/10.1590/S1413-86702007000100015
http://repositorio.unifesp.br/handle/11600/3532
Resumo: Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly.
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spelling Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unitMRSAmethicillin-resistant Staphylococcus aureusintensive care unit infectionsMethicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly.Taubaté UniversityFederal University of Rio Grande do NorteFederal University of São PauloUNIFESPSciELOBrazilian Society of Infectious DiseasesTaubaté UniversityFederal University of Rio Grande do NorteUniversidade Federal de São Paulo (UNIFESP)Moreira, Marina [UNIFESP]Freitas, Marise Reis de [UNIFESP]Martins, Sinaida Teixeira [UNIFESP]Castelo Filho, Adauto [UNIFESP]Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]2015-06-14T13:36:43Z2015-06-14T13:36:43Z2007-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion57-62application/pdfhttp://dx.doi.org/10.1590/S1413-86702007000100015Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007.10.1590/S1413-86702007000100015S1413-86702007000100015.pdf1413-8670S1413-86702007000100015http://repositorio.unifesp.br/handle/11600/3532WOS:000253997600015ark:/48912/001300000q81bengBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:01:01Zoai:repositorio.unifesp.br/:11600/3532Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:30:49.904652Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
title Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
spellingShingle Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
Moreira, Marina [UNIFESP]
MRSA
methicillin-resistant Staphylococcus aureus
intensive care unit infections
title_short Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
title_full Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
title_fullStr Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
title_full_unstemmed Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
title_sort Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
author Moreira, Marina [UNIFESP]
author_facet Moreira, Marina [UNIFESP]
Freitas, Marise Reis de [UNIFESP]
Martins, Sinaida Teixeira [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]
author_role author
author2 Freitas, Marise Reis de [UNIFESP]
Martins, Sinaida Teixeira [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Taubaté University
Federal University of Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Moreira, Marina [UNIFESP]
Freitas, Marise Reis de [UNIFESP]
Martins, Sinaida Teixeira [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]
dc.subject.por.fl_str_mv MRSA
methicillin-resistant Staphylococcus aureus
intensive care unit infections
topic MRSA
methicillin-resistant Staphylococcus aureus
intensive care unit infections
description Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly.
publishDate 2007
dc.date.none.fl_str_mv 2007-02-01
2015-06-14T13:36:43Z
2015-06-14T13:36:43Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1413-86702007000100015
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007.
10.1590/S1413-86702007000100015
S1413-86702007000100015.pdf
1413-8670
S1413-86702007000100015
http://repositorio.unifesp.br/handle/11600/3532
WOS:000253997600015
dc.identifier.dark.fl_str_mv ark:/48912/001300000q81b
url http://dx.doi.org/10.1590/S1413-86702007000100015
http://repositorio.unifesp.br/handle/11600/3532
identifier_str_mv Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007.
10.1590/S1413-86702007000100015
S1413-86702007000100015.pdf
1413-8670
S1413-86702007000100015
WOS:000253997600015
ark:/48912/001300000q81b
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 57-62
application/pdf
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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