Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000q81b |
Texto Completo: | http://dx.doi.org/10.1590/S1413-86702007000100015 http://repositorio.unifesp.br/handle/11600/3532 |
Resumo: | Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly. |
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Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unitMRSAmethicillin-resistant Staphylococcus aureusintensive care unit infectionsMethicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly.Taubaté UniversityFederal University of Rio Grande do NorteFederal University of São PauloUNIFESPSciELOBrazilian Society of Infectious DiseasesTaubaté UniversityFederal University of Rio Grande do NorteUniversidade Federal de São Paulo (UNIFESP)Moreira, Marina [UNIFESP]Freitas, Marise Reis de [UNIFESP]Martins, Sinaida Teixeira [UNIFESP]Castelo Filho, Adauto [UNIFESP]Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]2015-06-14T13:36:43Z2015-06-14T13:36:43Z2007-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion57-62application/pdfhttp://dx.doi.org/10.1590/S1413-86702007000100015Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007.10.1590/S1413-86702007000100015S1413-86702007000100015.pdf1413-8670S1413-86702007000100015http://repositorio.unifesp.br/handle/11600/3532WOS:000253997600015ark:/48912/001300000q81bengBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:01:01Zoai:repositorio.unifesp.br/:11600/3532Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:30:49.904652Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
title |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
spellingShingle |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit Moreira, Marina [UNIFESP] MRSA methicillin-resistant Staphylococcus aureus intensive care unit infections |
title_short |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
title_full |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
title_fullStr |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
title_full_unstemmed |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
title_sort |
Efficacy of a program of prevention and control for methicillin-resistant Staphylococcus aureus infections in an intensive-care unit |
author |
Moreira, Marina [UNIFESP] |
author_facet |
Moreira, Marina [UNIFESP] Freitas, Marise Reis de [UNIFESP] Martins, Sinaida Teixeira [UNIFESP] Castelo Filho, Adauto [UNIFESP] Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] |
author_role |
author |
author2 |
Freitas, Marise Reis de [UNIFESP] Martins, Sinaida Teixeira [UNIFESP] Castelo Filho, Adauto [UNIFESP] Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Taubaté University Federal University of Rio Grande do Norte Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Moreira, Marina [UNIFESP] Freitas, Marise Reis de [UNIFESP] Martins, Sinaida Teixeira [UNIFESP] Castelo Filho, Adauto [UNIFESP] Medeiros, Eduardo Alexandrino Servolo de [UNIFESP] |
dc.subject.por.fl_str_mv |
MRSA methicillin-resistant Staphylococcus aureus intensive care unit infections |
topic |
MRSA methicillin-resistant Staphylococcus aureus intensive care unit infections |
description |
Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in most Brazilian Hospitals, and there are few studies which show the efficacy of control measures in such situations. This study evaluated intensive care unit (ICU) patients, in two years divided in control, intervention and post-intervention group. Intervention measures: hands-on educational programs for healthcare workers; early identification of MRSA infected or colonized patients, labeled with a bed-identification tag for contact isolation; nasal carriers, patients, and healthcare professionals treated with topical mupirocin for five days. The hospital infection rates in the control period were compared to the ones in the post-intervention period. Hospital infection rates were found by means of the NNISS methodology The incidence coefficients of MRSA hospital infection (monthly average of 1,000 pts/day) in the control, intervention and post-intervention groups were respectively: 10.2, 5.1 and 2.5/1,000 pts/day (p<0.001) and MRSA-originated bloodstream infections were 3.6, 0.9 and 1.8/1,000 central venous catheter/day (p=0.281). Nasal colonization in both intervention and post-intervention periods was of 30.9% and 22.1% among the hospitalized patients, respectively 54.4% and 46.1% of whom were already MRSA-positive when admitted to the unit. In the intervention period, most of those MRSA infected patients (76.2%) were nasal carrier. Mortality rates were, respectively 26.6%; 27.3% and 21.0% (p<0.001). Nasal carriers, both patients (93.7%) and healthcare professionals (88.2%), were successfully treated with topical mupirocin. Intervention measures for the prevention and control of MRSA infections in ICUs, have been efficient in the reduction of the bloodstream and MRSA-originated hospital infections incidence, and reduced the overall mortality rate significantly. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-02-01 2015-06-14T13:36:43Z 2015-06-14T13:36:43Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1413-86702007000100015 Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007. 10.1590/S1413-86702007000100015 S1413-86702007000100015.pdf 1413-8670 S1413-86702007000100015 http://repositorio.unifesp.br/handle/11600/3532 WOS:000253997600015 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000q81b |
url |
http://dx.doi.org/10.1590/S1413-86702007000100015 http://repositorio.unifesp.br/handle/11600/3532 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 11, n. 1, p. 57-62, 2007. 10.1590/S1413-86702007000100015 S1413-86702007000100015.pdf 1413-8670 S1413-86702007000100015 WOS:000253997600015 ark:/48912/001300000q81b |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
57-62 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818602499408396288 |