Vertical growth phase and positive sentinel node in thin melanoma

Detalhes bibliográficos
Autor(a) principal: Oliveira Filho, Renato Santos de [UNIFESP]
Data de Publicação: 2003
Outros Autores: Ferreira, Lydia Masako [UNIFESP], Biasi, Luciano Jose [UNIFESP], Enokihara, Mílvia Maria Simões e Silva [UNIFESP], Paiva, Geruza Rezende [UNIFESP], Wagner, Jairo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2003000300009
http://repositorio.unifesp.br/handle/11600/1669
Resumo: Sentinel node (SN) status is the most important prognostic factor for localized melanoma. Usually, patients with Breslow thickness of less than 1.0 mm are not included in SN protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin melanoma. Ulceration, regression and high mitotic rate have been considered to be indications for an SN biopsy. The metastatic potential of the vertical growth phase is uncertain. To correlate pathological features in thin melanoma with SN metastasis, we reviewed 358 patients submitted to SN biopsy. Seventy-seven patients with lesions of 1 mm or smaller were included in the study group. Histological evaluation of the primary tumor included thickness, Clark level, mitotic rate, ulceration, regression, and growth phase. Lymphoscintigraphy was performed on all patients. Lymphatic mapping and gamma probe detection were both used for SN biopsy. Histological examination of SN consisted of hematoxylin-eosin and immunohistochemical staining. Median follow-up was 37 months. Six patients had micrometastases. Statistical analysis by the Fisher test showed that ulceration (P = 0.019), high mitotic rate (P = 0.008) and vertical growth phase (P = 0.002) were positively correlated with micrometastases. If other studies confirm these results, more melanoma patients must be submitted to SN biopsy.
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spelling Vertical growth phase and positive sentinel node in thin melanomaThin melanomaSentinel nodeLymphoscintigraphyImmunohistochemistryMicrometastasisSentinel node (SN) status is the most important prognostic factor for localized melanoma. Usually, patients with Breslow thickness of less than 1.0 mm are not included in SN protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin melanoma. Ulceration, regression and high mitotic rate have been considered to be indications for an SN biopsy. The metastatic potential of the vertical growth phase is uncertain. To correlate pathological features in thin melanoma with SN metastasis, we reviewed 358 patients submitted to SN biopsy. Seventy-seven patients with lesions of 1 mm or smaller were included in the study group. Histological evaluation of the primary tumor included thickness, Clark level, mitotic rate, ulceration, regression, and growth phase. Lymphoscintigraphy was performed on all patients. Lymphatic mapping and gamma probe detection were both used for SN biopsy. Histological examination of SN consisted of hematoxylin-eosin and immunohistochemical staining. Median follow-up was 37 months. Six patients had micrometastases. Statistical analysis by the Fisher test showed that ulceration (P = 0.019), high mitotic rate (P = 0.008) and vertical growth phase (P = 0.002) were positively correlated with micrometastases. If other studies confirm these results, more melanoma patients must be submitted to SN biopsy.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de CirurgiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PatologiaHospital Israelita Albert Einstein Serviço de Medicina NuclearUNIFESP, EPM, Depto. de CirurgiaUNIFESP, EPM, Depto. de PatologiaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Hospital Israelita Albert Einstein Serviço de Medicina NuclearOliveira Filho, Renato Santos de [UNIFESP]Ferreira, Lydia Masako [UNIFESP]Biasi, Luciano Jose [UNIFESP]Enokihara, Mílvia Maria Simões e Silva [UNIFESP]Paiva, Geruza Rezende [UNIFESP]Wagner, Jairo2015-06-14T13:29:57Z2015-06-14T13:29:57Z2003-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion347-350application/pdfhttp://dx.doi.org/10.1590/S0100-879X2003000300009Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 3, p. 347-350, 2003.10.1590/S0100-879X2003000300009S0100-879X2003000300009.pdf0100-879XS0100-879X2003000300009http://repositorio.unifesp.br/handle/11600/1669WOS:000181920300009engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T22:48:25Zoai:repositorio.unifesp.br/:11600/1669Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T22:48:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Vertical growth phase and positive sentinel node in thin melanoma
title Vertical growth phase and positive sentinel node in thin melanoma
spellingShingle Vertical growth phase and positive sentinel node in thin melanoma
Oliveira Filho, Renato Santos de [UNIFESP]
Thin melanoma
Sentinel node
Lymphoscintigraphy
Immunohistochemistry
Micrometastasis
title_short Vertical growth phase and positive sentinel node in thin melanoma
title_full Vertical growth phase and positive sentinel node in thin melanoma
title_fullStr Vertical growth phase and positive sentinel node in thin melanoma
title_full_unstemmed Vertical growth phase and positive sentinel node in thin melanoma
title_sort Vertical growth phase and positive sentinel node in thin melanoma
author Oliveira Filho, Renato Santos de [UNIFESP]
author_facet Oliveira Filho, Renato Santos de [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
Biasi, Luciano Jose [UNIFESP]
Enokihara, Mílvia Maria Simões e Silva [UNIFESP]
Paiva, Geruza Rezende [UNIFESP]
Wagner, Jairo
author_role author
author2 Ferreira, Lydia Masako [UNIFESP]
Biasi, Luciano Jose [UNIFESP]
Enokihara, Mílvia Maria Simões e Silva [UNIFESP]
Paiva, Geruza Rezende [UNIFESP]
Wagner, Jairo
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hospital Israelita Albert Einstein Serviço de Medicina Nuclear
dc.contributor.author.fl_str_mv Oliveira Filho, Renato Santos de [UNIFESP]
Ferreira, Lydia Masako [UNIFESP]
Biasi, Luciano Jose [UNIFESP]
Enokihara, Mílvia Maria Simões e Silva [UNIFESP]
Paiva, Geruza Rezende [UNIFESP]
Wagner, Jairo
dc.subject.por.fl_str_mv Thin melanoma
Sentinel node
Lymphoscintigraphy
Immunohistochemistry
Micrometastasis
topic Thin melanoma
Sentinel node
Lymphoscintigraphy
Immunohistochemistry
Micrometastasis
description Sentinel node (SN) status is the most important prognostic factor for localized melanoma. Usually, patients with Breslow thickness of less than 1.0 mm are not included in SN protocols. However, the literature presents a rate ranging from 3 to 7% of nodal recurrence in thin melanoma. Ulceration, regression and high mitotic rate have been considered to be indications for an SN biopsy. The metastatic potential of the vertical growth phase is uncertain. To correlate pathological features in thin melanoma with SN metastasis, we reviewed 358 patients submitted to SN biopsy. Seventy-seven patients with lesions of 1 mm or smaller were included in the study group. Histological evaluation of the primary tumor included thickness, Clark level, mitotic rate, ulceration, regression, and growth phase. Lymphoscintigraphy was performed on all patients. Lymphatic mapping and gamma probe detection were both used for SN biopsy. Histological examination of SN consisted of hematoxylin-eosin and immunohistochemical staining. Median follow-up was 37 months. Six patients had micrometastases. Statistical analysis by the Fisher test showed that ulceration (P = 0.019), high mitotic rate (P = 0.008) and vertical growth phase (P = 0.002) were positively correlated with micrometastases. If other studies confirm these results, more melanoma patients must be submitted to SN biopsy.
publishDate 2003
dc.date.none.fl_str_mv 2003-03-01
2015-06-14T13:29:57Z
2015-06-14T13:29:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2003000300009
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 3, p. 347-350, 2003.
10.1590/S0100-879X2003000300009
S0100-879X2003000300009.pdf
0100-879X
S0100-879X2003000300009
http://repositorio.unifesp.br/handle/11600/1669
WOS:000181920300009
url http://dx.doi.org/10.1590/S0100-879X2003000300009
http://repositorio.unifesp.br/handle/11600/1669
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 3, p. 347-350, 2003.
10.1590/S0100-879X2003000300009
S0100-879X2003000300009.pdf
0100-879X
S0100-879X2003000300009
WOS:000181920300009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 347-350
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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