Hepatotoxicidade induzida por Hypericum perforatum com possível associação a copaíba (Copaifera langsdorffii Desf): relato de caso

• Autor(a) principal: Agollo, Marjorie Costa
• Data de Publicação: 2014
• Outros Autores: Miszputen, Sender Jankiel, Diament, Jayme
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S1679-45082014RC2953; http://repositorio.unifesp.br/handle/11600/8541
• topic: Drug-induced liver injury; Hypericum/adverse effects; Phytotherapeutic drugs/adverse effects; Case reports; Doença hepática induzida por droga; Hypericum/efeitos adversos; Medicamentos fitoterápicos/efeitos adversos; Relatos de casos

We report a case of liver damage in an elderly patient after the use of herbal products of Hypericum perforatum and copaiba (Copaifera langsdorffii Desf). Hepatotoxicity related to Hypericum perforatum is anecdotally known, but for copaiba, widely used as anti-inflammatory, there is just experimental data in the national literature. This report aimed to draw attention to the possible toxic effects of this association as well as to the clinical recovery of the patient after discontinuing their use. There is a tendency to suspect of the action of drugs to justify a non-viral acute liver injury, because of the large number of drugs responsible for hepatotoxicity. There are experiments and clinical reports in the literature describing some herbal products, including Hypericum perforatum, as the causative agents of this aggression, and are considered innocuous and used with no restrictions. We must remember that adverse reactions also occur with these substances; hence, they should be investigated when collecting the patient´s history, for leading to severe liver failure.