Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/31126 http://dx.doi.org/10.1186/1758-5996-1-8 |
Resumo: | Purpose: There is a significant association between insulin resistance and low cardiorespiratory fitness in nondiabetic subjects. in a population with risk factors for type 2 diabetes (T2DM), before they are insulin resistant, we investigated low exercise capacity (VO2max) as an early marker of impaired insulin sensitivity in order to determine earlier interventions to prevent development of insulin resistance syndrome (IRS) and T2DM.Methods: Cross-sectional analyses of data on 369 (78 men and 291 women) people at risk for IRS and T2DM, aged 45.6 +/- 10 years (20-65 years) old from the Community Diabetes Prevention Project in Minnesota were carried out. the cardiorespiratory fitness (VO2max) by respiratory gas exchange and bicycle ergometer were measured in our at risk non insulin resistant population and compared with a control group living in the same geographic area. Both groups were equally sedentary, matched for age, gender and BMI.Results: the most prevalent abnormality in the study population was markedly low VO2max when compared with general work site screening control group, (n = 177; 137F; 40 M, mean age 40 +/- 11 years; BMI = 27.8 +/- 6.1 kg/m(2)). Individuals at risk for IRS and T2DM had a VO2max (22 +/- 6 ml/kg/min) 15% lower than the control group VO2max (26 +/- 9 ml/kg/min) (p < 0.001). It was foun that VO(2)max was inversely correlated with HOMA-IR (r = -0.30, p < 0.0001).Conclusions: Decreased VO2max is correlated with impaired insulin sensitivity and was the most prevalent abnormality in a population at risk for IRS and T2DM but without overt disease. This raises the possibility that decreased VO2 max is among the earliest indicators of IRS and T2DM therefore, an important risk factor for disease progression. |
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Leite, Silmara A. O.Monk, Arlene M.Upham, Paul A.Chacra, Antonio R. [UNIFESP]Bergenstal, Richard M.Univ PositUniversidade Federal de São Paulo (UNIFESP)Int Diabet Ctr2016-01-24T13:52:00Z2016-01-24T13:52:00Z2009-01-01Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 1, 6 p., 2009.1758-5996http://repositorio.unifesp.br/handle/11600/31126http://dx.doi.org/10.1186/1758-5996-1-8WOS000207918200008.pdf10.1186/1758-5996-1-8WOS:000207918200008Purpose: There is a significant association between insulin resistance and low cardiorespiratory fitness in nondiabetic subjects. in a population with risk factors for type 2 diabetes (T2DM), before they are insulin resistant, we investigated low exercise capacity (VO2max) as an early marker of impaired insulin sensitivity in order to determine earlier interventions to prevent development of insulin resistance syndrome (IRS) and T2DM.Methods: Cross-sectional analyses of data on 369 (78 men and 291 women) people at risk for IRS and T2DM, aged 45.6 +/- 10 years (20-65 years) old from the Community Diabetes Prevention Project in Minnesota were carried out. the cardiorespiratory fitness (VO2max) by respiratory gas exchange and bicycle ergometer were measured in our at risk non insulin resistant population and compared with a control group living in the same geographic area. Both groups were equally sedentary, matched for age, gender and BMI.Results: the most prevalent abnormality in the study population was markedly low VO2max when compared with general work site screening control group, (n = 177; 137F; 40 M, mean age 40 +/- 11 years; BMI = 27.8 +/- 6.1 kg/m(2)). Individuals at risk for IRS and T2DM had a VO2max (22 +/- 6 ml/kg/min) 15% lower than the control group VO2max (26 +/- 9 ml/kg/min) (p < 0.001). It was foun that VO(2)max was inversely correlated with HOMA-IR (r = -0.30, p < 0.0001).Conclusions: Decreased VO2max is correlated with impaired insulin sensitivity and was the most prevalent abnormality in a population at risk for IRS and T2DM but without overt disease. This raises the possibility that decreased VO2 max is among the earliest indicators of IRS and T2DM therefore, an important risk factor for disease progression.Park Nicollet FoundationJohn and Nancy Berg Family FoundationUniv Posit, Curitiba, PR, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilInt Diabet Ctr, Minneapolis, MN USAUniversidade Federal de São Paulo, Disciplina de Endocrinologia, São Paulo, SP, BrazilWeb of Science6engBiomed Central LtdDiabetology & Metabolic SyndromeLow cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000207918200008.pdfapplication/pdf475896${dspace.ui.url}/bitstream/11600/31126/1/WOS000207918200008.pdffcd024ffd05d77861adb133bc3beefa6MD51open accessTEXTWOS000207918200008.pdf.txtWOS000207918200008.pdf.txtExtracted texttext/plain24363${dspace.ui.url}/bitstream/11600/31126/2/WOS000207918200008.pdf.txt70033fa23d99ea9edf14168e5621db9fMD52open access11600/311262023-01-30 23:10:02.736open accessoai:repositorio.unifesp.br:11600/31126Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-01-31T02:10:02Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
title |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
spellingShingle |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance Leite, Silmara A. O. |
title_short |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
title_full |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
title_fullStr |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
title_full_unstemmed |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
title_sort |
Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance |
author |
Leite, Silmara A. O. |
author_facet |
Leite, Silmara A. O. Monk, Arlene M. Upham, Paul A. Chacra, Antonio R. [UNIFESP] Bergenstal, Richard M. |
author_role |
author |
author2 |
Monk, Arlene M. Upham, Paul A. Chacra, Antonio R. [UNIFESP] Bergenstal, Richard M. |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Posit Universidade Federal de São Paulo (UNIFESP) Int Diabet Ctr |
dc.contributor.author.fl_str_mv |
Leite, Silmara A. O. Monk, Arlene M. Upham, Paul A. Chacra, Antonio R. [UNIFESP] Bergenstal, Richard M. |
description |
Purpose: There is a significant association between insulin resistance and low cardiorespiratory fitness in nondiabetic subjects. in a population with risk factors for type 2 diabetes (T2DM), before they are insulin resistant, we investigated low exercise capacity (VO2max) as an early marker of impaired insulin sensitivity in order to determine earlier interventions to prevent development of insulin resistance syndrome (IRS) and T2DM.Methods: Cross-sectional analyses of data on 369 (78 men and 291 women) people at risk for IRS and T2DM, aged 45.6 +/- 10 years (20-65 years) old from the Community Diabetes Prevention Project in Minnesota were carried out. the cardiorespiratory fitness (VO2max) by respiratory gas exchange and bicycle ergometer were measured in our at risk non insulin resistant population and compared with a control group living in the same geographic area. Both groups were equally sedentary, matched for age, gender and BMI.Results: the most prevalent abnormality in the study population was markedly low VO2max when compared with general work site screening control group, (n = 177; 137F; 40 M, mean age 40 +/- 11 years; BMI = 27.8 +/- 6.1 kg/m(2)). Individuals at risk for IRS and T2DM had a VO2max (22 +/- 6 ml/kg/min) 15% lower than the control group VO2max (26 +/- 9 ml/kg/min) (p < 0.001). It was foun that VO(2)max was inversely correlated with HOMA-IR (r = -0.30, p < 0.0001).Conclusions: Decreased VO2max is correlated with impaired insulin sensitivity and was the most prevalent abnormality in a population at risk for IRS and T2DM but without overt disease. This raises the possibility that decreased VO2 max is among the earliest indicators of IRS and T2DM therefore, an important risk factor for disease progression. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:52:00Z |
dc.date.available.fl_str_mv |
2016-01-24T13:52:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 1, 6 p., 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/31126 http://dx.doi.org/10.1186/1758-5996-1-8 |
dc.identifier.issn.none.fl_str_mv |
1758-5996 |
dc.identifier.file.none.fl_str_mv |
WOS000207918200008.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1186/1758-5996-1-8 |
dc.identifier.wos.none.fl_str_mv |
WOS:000207918200008 |
identifier_str_mv |
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 1, 6 p., 2009. 1758-5996 WOS000207918200008.pdf 10.1186/1758-5996-1-8 WOS:000207918200008 |
url |
http://repositorio.unifesp.br/handle/11600/31126 http://dx.doi.org/10.1186/1758-5996-1-8 |
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eng |
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Diabetology & Metabolic Syndrome |
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Biomed Central Ltd |
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Biomed Central Ltd |
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