EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43386 http://dx.doi.org/10.1042/cs0810465 |
Resumo: | 1. The influence of thyroparathyroidectomy and/or acidosis on renal function and specifically on acid excretion was studied in rats treated with a cumulative dose of 2 mg of aluminium.2. Aluminium-treated and non-treated thyroparathyroidectomized rats showed a significant decrease in glomerular filtration rate and in the urinary/plasma inulin ratio without alteration in net acid excretion.3. Non-treated thyroparathyroidectomized acidotic rats showed a significant fall in the amount of ammonium excreted and in overall acid excretion, suggesting that parathyroid hormone participates in an important way in the defence against metabolic acidosis.4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated rats, thyroparathyroidectomy had no effect on renal acid excretion, suggesting that aluminium even in low doses inhibited the action of PTH on the renal tubule.5. After exposure to aluminium, the relative inhibition of PTH on the renal tubule may become an additional factor that could contribute to the worsening of clinical conditions in which an inappropriate retention of acid loads can occur. |
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Gil, Frida Zaladek [UNIFESP]Silva, VLCCavanal, Maria de Fátima [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-15T17:05:05Z2018-06-15T17:05:05Z1991-10-01Clinical Science. London: Portland Press, v. 81, n. 4, p. 465-470, 1991.0143-5221http://repositorio.unifesp.br/11600/43386http://dx.doi.org/10.1042/cs081046510.1042/cs0810465WOS:A1991GJ713000031. The influence of thyroparathyroidectomy and/or acidosis on renal function and specifically on acid excretion was studied in rats treated with a cumulative dose of 2 mg of aluminium.2. Aluminium-treated and non-treated thyroparathyroidectomized rats showed a significant decrease in glomerular filtration rate and in the urinary/plasma inulin ratio without alteration in net acid excretion.3. Non-treated thyroparathyroidectomized acidotic rats showed a significant fall in the amount of ammonium excreted and in overall acid excretion, suggesting that parathyroid hormone participates in an important way in the defence against metabolic acidosis.4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated rats, thyroparathyroidectomy had no effect on renal acid excretion, suggesting that aluminium even in low doses inhibited the action of PTH on the renal tubule.5. After exposure to aluminium, the relative inhibition of PTH on the renal tubule may become an additional factor that could contribute to the worsening of clinical conditions in which an inappropriate retention of acid loads can occur.ESCOLA PAULISTA MED SCH,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETABOL,BR-04023 SAO PAULO,BRAZILESCOLA PAULISTA MED SCH,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETABOL,BR-04023 SAO PAULO,BRAZILWeb of Science465-470engPortland PressClinical ScienceALUMINUMMETABOLIC ACIDOSISPARATHYROID HORMONERENAL ACID EXCRETIONRENAL FUNCTIONEFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONEinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/433862021-09-30 17:28:01.801metadata only accessoai:repositorio.unifesp.br:11600/43386Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-30T20:28:01Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
title |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
spellingShingle |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE Gil, Frida Zaladek [UNIFESP] ALUMINUM METABOLIC ACIDOSIS PARATHYROID HORMONE RENAL ACID EXCRETION RENAL FUNCTION |
title_short |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
title_full |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
title_fullStr |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
title_full_unstemmed |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
title_sort |
EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE |
author |
Gil, Frida Zaladek [UNIFESP] |
author_facet |
Gil, Frida Zaladek [UNIFESP] Silva, VLC Cavanal, Maria de Fátima [UNIFESP] |
author_role |
author |
author2 |
Silva, VLC Cavanal, Maria de Fátima [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Gil, Frida Zaladek [UNIFESP] Silva, VLC Cavanal, Maria de Fátima [UNIFESP] |
dc.subject.eng.fl_str_mv |
ALUMINUM METABOLIC ACIDOSIS PARATHYROID HORMONE RENAL ACID EXCRETION RENAL FUNCTION |
topic |
ALUMINUM METABOLIC ACIDOSIS PARATHYROID HORMONE RENAL ACID EXCRETION RENAL FUNCTION |
description |
1. The influence of thyroparathyroidectomy and/or acidosis on renal function and specifically on acid excretion was studied in rats treated with a cumulative dose of 2 mg of aluminium.2. Aluminium-treated and non-treated thyroparathyroidectomized rats showed a significant decrease in glomerular filtration rate and in the urinary/plasma inulin ratio without alteration in net acid excretion.3. Non-treated thyroparathyroidectomized acidotic rats showed a significant fall in the amount of ammonium excreted and in overall acid excretion, suggesting that parathyroid hormone participates in an important way in the defence against metabolic acidosis.4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated rats, thyroparathyroidectomy had no effect on renal acid excretion, suggesting that aluminium even in low doses inhibited the action of PTH on the renal tubule.5. After exposure to aluminium, the relative inhibition of PTH on the renal tubule may become an additional factor that could contribute to the worsening of clinical conditions in which an inappropriate retention of acid loads can occur. |
publishDate |
1991 |
dc.date.issued.fl_str_mv |
1991-10-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T17:05:05Z |
dc.date.available.fl_str_mv |
2018-06-15T17:05:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical Science. London: Portland Press, v. 81, n. 4, p. 465-470, 1991. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43386 http://dx.doi.org/10.1042/cs0810465 |
dc.identifier.issn.none.fl_str_mv |
0143-5221 |
dc.identifier.doi.none.fl_str_mv |
10.1042/cs0810465 |
dc.identifier.wos.none.fl_str_mv |
WOS:A1991GJ71300003 |
identifier_str_mv |
Clinical Science. London: Portland Press, v. 81, n. 4, p. 465-470, 1991. 0143-5221 10.1042/cs0810465 WOS:A1991GJ71300003 |
url |
http://repositorio.unifesp.br/11600/43386 http://dx.doi.org/10.1042/cs0810465 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinical Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
465-470 |
dc.publisher.none.fl_str_mv |
Portland Press |
publisher.none.fl_str_mv |
Portland Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764137270345728 |