Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/56426 http://dx.doi.org/10.1039/c6ra28633j |
Resumo: | The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac) 3), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have an average hydrodynamic size of (78.0 +/- 0.9) nm, average size distribution (PDI) of 0.302 +/- 0.04, and zeta potential of (-22.10 +/- 0.55) mV. Free thiol groups on the Fe3O4-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding S-nitrosated magnetic nanoparticles (Fe3O4-Snitroso-MSA NPs), which act as spontaneous NO donors upon S-N bond cleavage. The amount of (86.4 +/- 4.7) mmol of NO was released per gram of Fe3O4-S-nitroso-MSA NPs. In order to enhance NP dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface. |
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Goncalves, L. C. [UNIFESP]Seabra, Amedea Barozzi [UNIFESP]Pelegrino, Milena Trevisan [UNIFESP]Araujo, Daniele Ribeiro deBernardes, Juliana SilvaHaddad, Paula Silvia [UNIFESP]2020-07-31T12:46:52Z2020-07-31T12:46:52Z2017Rsc Advances. Cambridge, v. 7, n. 24, p. 14496-14503, 2017.2046-2069https://repositorio.unifesp.br/handle/11600/56426http://dx.doi.org/10.1039/c6ra28633jWOS000396150900025.pdf10.1039/c6ra28633jWOS:000396150900025The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac) 3), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have an average hydrodynamic size of (78.0 +/- 0.9) nm, average size distribution (PDI) of 0.302 +/- 0.04, and zeta potential of (-22.10 +/- 0.55) mV. Free thiol groups on the Fe3O4-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding S-nitrosated magnetic nanoparticles (Fe3O4-Snitroso-MSA NPs), which act as spontaneous NO donors upon S-N bond cleavage. The amount of (86.4 +/- 4.7) mmol of NO was released per gram of Fe3O4-S-nitroso-MSA NPs. In order to enhance NP dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Newton Advanced Fellowship (The Royal Society)Complexo Laboratorial Nanotecnologico (CLN) - UFABC - SisNanoUniv Fed Sao Paulo, Exact & Earth Sci Dept, UNIFESP, Diadema, SP, BrazilUniv Fed ABC, Human & Nat Sci Ctr, Santo Andre, SP, BrazilCNPEM, Brazilian Ctr Res Energy & Mat, Campinas, SP, BrazilExact and Earth Science Department, Universidade Federal de São Paulo, UNIFESP, Diadema, BrazilFAPESP: 2014/13913-7FAPESP: 2016/10347-6Newton Advanced Fellowship (The Royal Society): NA140046SisNano: 402289/2013-7Web of Science14496-14503engRoyal Soc ChemistryRsc AdvancesSuperparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applicationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCambridge724info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000396150900025.pdfapplication/pdf837005${dspace.ui.url}/bitstream/11600/56426/1/WOS000396150900025.pdf3169b384290e501846e1d3fc9ea99583MD51open accessTEXTWOS000396150900025.pdf.txtWOS000396150900025.pdf.txtExtracted texttext/plain43935${dspace.ui.url}/bitstream/11600/56426/8/WOS000396150900025.pdf.txtb1a791a0c17567e55fc4db3ef4b072d9MD58open accessTHUMBNAILWOS000396150900025.pdf.jpgWOS000396150900025.pdf.jpgIM Thumbnailimage/jpeg7429${dspace.ui.url}/bitstream/11600/56426/10/WOS000396150900025.pdf.jpg6e853930e92ba2ce885e9ce09d37974dMD510open access11600/564262023-06-05 19:22:49.235open accessoai:repositorio.unifesp.br:11600/56426Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:22:49Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
title |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
spellingShingle |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications Goncalves, L. C. [UNIFESP] |
title_short |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
title_full |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
title_fullStr |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
title_full_unstemmed |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
title_sort |
Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications |
author |
Goncalves, L. C. [UNIFESP] |
author_facet |
Goncalves, L. C. [UNIFESP] Seabra, Amedea Barozzi [UNIFESP] Pelegrino, Milena Trevisan [UNIFESP] Araujo, Daniele Ribeiro de Bernardes, Juliana Silva Haddad, Paula Silvia [UNIFESP] |
author_role |
author |
author2 |
Seabra, Amedea Barozzi [UNIFESP] Pelegrino, Milena Trevisan [UNIFESP] Araujo, Daniele Ribeiro de Bernardes, Juliana Silva Haddad, Paula Silvia [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Goncalves, L. C. [UNIFESP] Seabra, Amedea Barozzi [UNIFESP] Pelegrino, Milena Trevisan [UNIFESP] Araujo, Daniele Ribeiro de Bernardes, Juliana Silva Haddad, Paula Silvia [UNIFESP] |
description |
The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac) 3), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have an average hydrodynamic size of (78.0 +/- 0.9) nm, average size distribution (PDI) of 0.302 +/- 0.04, and zeta potential of (-22.10 +/- 0.55) mV. Free thiol groups on the Fe3O4-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding S-nitrosated magnetic nanoparticles (Fe3O4-Snitroso-MSA NPs), which act as spontaneous NO donors upon S-N bond cleavage. The amount of (86.4 +/- 4.7) mmol of NO was released per gram of Fe3O4-S-nitroso-MSA NPs. In order to enhance NP dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-31T12:46:52Z |
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2020-07-31T12:46:52Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Rsc Advances. Cambridge, v. 7, n. 24, p. 14496-14503, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/56426 http://dx.doi.org/10.1039/c6ra28633j |
dc.identifier.issn.none.fl_str_mv |
2046-2069 |
dc.identifier.file.none.fl_str_mv |
WOS000396150900025.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1039/c6ra28633j |
dc.identifier.wos.none.fl_str_mv |
WOS:000396150900025 |
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Rsc Advances. Cambridge, v. 7, n. 24, p. 14496-14503, 2017. 2046-2069 WOS000396150900025.pdf 10.1039/c6ra28633j WOS:000396150900025 |
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Royal Soc Chemistry |
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Royal Soc Chemistry |
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