Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1186/1745-6215-13-153 http://repositorio.unifesp.br/handle/11600/35182 |
Resumo: | Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART).Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. the intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. in the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). in both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. the primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle.Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method. |
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Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trialAcute respiratory distress syndromeAlveolar recruitmentPEEPMechanical ventilationClinical trialsRandomizedBackground: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART).Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. the intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. in the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). in both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. the primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle.Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hosp Urgencias & Emergencias Rio Branco HUERB, Rio Branco, AC, BrazilHosp & Pronto Socorro 28 Agosto, Manaus, Amazonas, BrazilUNIMED Manaus, Manaus, Amazonas, BrazilFundacao Hosp Adriano Jorge, Manaus, Amazonas, BrazilHosp Santa Izabel Santa Casa Misericordia Bahia, Salvador, BA, BrazilHosp Reg Juazeiro Gestao IMIP, Juazeiro, BA, BrazilHosp Univ Prof Edgar Santos, Salvador, BA, BrazilHosp Espanhol, Salvador, BA, BrazilHosp Geral Roberto Santos, Salvador, BA, BrazilHosp Messejana, Fortaleza, Ceara, BrazilHosp Reg Samambaia, Brasilia, DF, BrazilHosp Reg Asa Norte HRAN, Brasilia, DF, BrazilHosp Santa Luzia, Brasilia, DF, BrazilHosp Santa Lucia, Brasilia, DF, BrazilHosp Anchieta, Brasilia, DF, BrazilCtr Integrado Atencao Saude CIAS, 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BrazilFundacao Santa Casa Misericordia Para, Belem, Para, BrazilHosp Emergencia Trauma Senador Humberto Lucena, Joao Pessoa, Paraiba, BrazilHosp UNIMED Joao Pessoa, Joao Pessoa, Paraiba, BrazilHosp Alfa, Recife, PE, BrazilHosp Evangel Londrina, Londrina, PR, BrazilHosp Univ Reg Norte Parana, Londrina, PR, BrazilHosp Sao Lucas FAG, Cascavel, PR, BrazilHosp Univ Reg Maringa, Maringa, Parana, BrazilHosp Santa Casa Campo Mourao, Campo Mourao, PR, BrazilHosp Santa Tereza Guarapuava, Guarapuava, PR, BrazilHosp Clin Padre Miguel, Rio de Janeiro, RJ, BrazilHosp Prontocardio, Campos Dos Goytacazes, RJ, BrazilClin Sao Vicente, Rio de Janeiro, RJ, BrazilHosp Barra DOr, Rio de Janeiro, RJ, BrazilHosp Monte Sinai, Ariquemes, RO, BrazilHosp Estadual & Pronto Socorro Joao Paulo II, Porto Velho, RO, BrazilHosp Geral Roraima, Boa Vista, RR, BrazilHosp Nossa Senhora Conceicao, Porto Alegre, RS, BrazilHosp Moinhos Vento, Porto Alegre, RS, BrazilUTI Cent Irmandade Santa Casa Misericordia Porto, Porto Alegre, RS, BrazilUTI Pavilhao Pereira Filho Santa Casa Misericord, Porto Alegre, RS, BrazilHosp Sao Lucas PUCRS, Porto Alegre, RS, BrazilHosp Clin Porto Alegre HCPA, Porto Alegre, RS, BrazilHosp Univ Sao Francisco Paula, Pelotas, RS, BrazilHosp Coracao, Balneario de Camboriu, SC, BrazilHosp Univ UFSC, Florianopolis, SC, BrazilHosp Nereu Ramos, Florianopolis, SC, BrazilHosp UNIMED Joinville, Joinville, SC, BrazilHosp Sao Jose, Joinville, SC, BrazilHosp Reg Hans Dieter Schmidt, Joinville, SC, BrazilAssoc Hosp & Maternidade Consul Carlos Renaux, Brusque, SC, BrazilHosp Primavera, Aracaju, SE, BrazilHosp Urgencia Sergipe HUSE, Aracaju, SE, BrazilHosp Coracao HCor, São Paulo, BrazilUniversidade Federal de São Paulo, Hosp São Paulo, UTI Clin Med, São Paulo, BrazilFMUSP, Hosp Clin, UTI Resp, São Paulo, BrazilFMUSP, Hosp Clin, UTI Clin, São Paulo, BrazilFMUSP, Hosp Clin, UAC 1, São Paulo, BrazilFMUSP, Hosp Clin, UAC 2, São Paulo, BrazilFMUSP, Hosp Clin, UTI Nefrol, São Paulo, BrazilFMUSP, 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Paulista, SP, BrazilHosp UNIMED, Aracatuba, SP, BrazilHosp Bandeirantes, São Paulo, BrazilHosp Geral Sao Mateus Dr Manoel Bifulco, São Paulo, BrazilInst Infectol Emilio Ribas, São Paulo, BrazilUniv Estadual Campinas, Hosp Clin, Campinas, SP, BrazilHosp Clin Luzia de Pinho & Melo SPDM, Mogi Das Cruzes, SP, BrazilIrmandade Santa Casa Misericordia Mogi Guacu, Mogi Guacu, SP, BrazilInst Canc Estado São Paulo ICESP, São Paulo, BrazilHosp Maternidade UNIMED Leste Paulista, Sao Joao Da Boa Vista, SP, BrazilFdn Cardiovasc Colombia, Bucaramanga, ColombiaLos Comuneros Hosp Univ Bucaramanga, Bucaramanga, ColombiaOrg Latinoamer Fomento Invest Salud OLFSI, Bucaramanga, ColombiaMedica Sur, Mexico City, DF, MexicoAzienda Osped Univ P Giaccone, Palermo, ItalyHosp Coracao IEP HCor, Res Inst, BR-04005000 São Paulo, BrazilUniversidade Federal de São Paulo, Hosp São Paulo, UTI Clin Med, São Paulo, BrazilUniversidade Federal de São Paulo, Hosp São Paulo, UTI Pronto Socorro, São Paulo, BrazilUniversidade Federal de São Paulo, Hosp São Paulo, UTI Anestesiol, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Oncol Pediat GRAACC, São Paulo, BrazilWeb of ScienceHospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of HealthBiomed Central LtdHosp Urgencias & Emergencias Rio Branco HUERBHosp & Pronto Socorro 28 AgostoUNIMED ManausFundacao Hosp Adriano JorgeHosp Santa Izabel Santa Casa Misericordia BahiaHosp Reg Juazeiro Gestao IMIPHosp Univ Prof Edgar SantosHosp EspanholHosp Geral Roberto SantosHosp MessejanaHosp Reg SamambaiaHosp Reg Asa Norte HRANHosp Santa LuziaHosp Santa LuciaHosp AnchietaCtr Integrado Atencao Saude CIASHosp Evangel Cachoeiro ItapemirinVitoria Apart HospVila Velha HospHosp Clin UFESHosp Clin UFGHosp Geral Tarquinio Lopes FilhoUDI HospSanta Casa Misericordia Ouro PretoHosp Eduardo de MenezesFundacao Hosp Sao SebastiaoHosp Conego Monte RasoHosp Municipal Odilon BehrensHosp Sao Lucas Governador 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P.Tallo, Fernando S.Rezende, Ederlon A. C.Telles, Jose M. M.Romano, EdsonGuimaraes, Helio P.Regenga, Marisa M.Takahashi, Luzia N.Teixeira, CassianoOliveira, Roselaine P.Carvalho, Vitor O.Diaz-Quijano, Fredi A.Carvalho, Carlos R. R.Kodama, Alessandra A.Ribeiro, Gisele F. M.Abreu, Matheus O.Oliveira, Ivonaldo M.Guyatt, GordonFerguson, NiallWalter, StephenVasconcelos, Marcia O. M.Segundo, Valerio J.Ferraz, Iris L.Silva, Rosicley S.Oliveira Filho, Wilson deSilva, Nelson B.Heirel, Debora C. B.Takatani, Rodrigo R.Sousa Neto, Jefferson A.Neto, Jeronimo C. B.Almeida, Samara D.Chamy, GaucoGoncalves Neto, Graciliano J. L.Dias, Alysson P.Silva, Rozangela R.Tavares, Roberta C.Souza, Marcia L. V. D.Decio, Janaina C.Lima, Cyntia M. L. S.Ferreira Neto, FleuryOliveira, Katia R.Dias, Polyana P. L. C.Brandao, Andre L. S. B.Ramos, Joroastro E.Vasconcelos, Paula T.Flores, Dimitri G.Pinheiro Filho, Gilvan R.Andrade, Isaac G.Martinez, AmadeuFranca, Gustavo G. P.Monteiro, Livia L.Correia, Emmanuel I. 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C.Kleber, WladmyCarvalho, Waneska L. N.Winveler, Georgia F. P.Chagas Filho, AldirCavalcanti, Raphael AliGrion, Cintia M. C.Reis, Andrezza T. J. B.Festti, JosianeGimenez, Francielli M. P.Larangeira, Alexandre S.Cardoso, Lucienne T. Q.Mezzaroba, Ana L.Giancursi, Thiago S.Kauss, Ivanil A. M.Duarte, Pericles A. D.Tozo, Tatiane C.Peliser, PriscilaGermano, AlmirGurgel, Sanderland J. T.Silva, Sandra R. B.Kuroda, Cristina M.Herek, AndreaYamada, Sergio S.Schiavetto, Paulo M.Wysocki, NatachaMatsubara, Rosely R.Sales, Joao A. L.Laprovita, Maria P.Pena, Felipe M.Sa, AlexandreVianna, ArthurVerdeal, Juan C.Martins, Gloria A.Salgado, Diamantino R.Coelho, Adalberto M.Coelho, Milena P. P. M.Morong, Aline S.Poquiriqui, Rodolfo M. B.Ferreira, Ana P.Lucena, Debora N. L.Marino, Nathalia F.Moreira, Monique A.Uratani, Cristiana C. S.Severino, Marta A.Silva, Patricia N.Medeiros, Luciana G.Chaves Filho, Francisco G.Guimaraes, Daniela M. Q. S.Rezende, Valeria M. C.Carbonell, Roberto C. C.Trindade, Renata S.Pellegrini, Jose A. S.Boniatti, Marcio M.Santos, Moreno C.Boldo, RodrigoOliveira, Vanessa M.Correa, Viviane M.Nedel, WagnerSchaich, FelipeTagliari, LucianaSavi, AugustoSchulz, Luis F.Maccari, Juara G.Seeger, Gabriela M.Foernges, Rafael B.Rieder, Marcelo M.Becker, Daniel A.Broilo, Fabiano P.Schwarz, PatriciaAlencastro, AndreBerto, PaulaBackes, FabianeDias, Fernando S.Blattner, ClarissaMartins, Edna T. J.Scaglia, Nris C.Vieira, Silvia R. R.Prado, Karen F.Fialkow, LeaFranke, CristianoVieira, Debora F. V. B.Moraes, Rafael B.Marques, Leonardo S.Hopf, Joao L. S.Wawrzeniak, Iuri C.Rech, Tatiana H.Albuquerque, Regis B.Guerreiro, Marcio O.Teixeira, Luciano O.Macedo, Pedro L.Bainy, Marina P.Ferreira, Edgard V.Martins, Marcio A.Andrade, Luciana A. S.Machado, Fernando O.Burigo, Ana C.Pincelli, MariangelaKretzer, LaraMaia, Israel S.Cordeiro, Rodrigo B.Westphal, GlaucoCaldeira, MiltonCramer, Amanda S.Dadam, Michelli M.Barbosa, Pierry O.Brilenger, Caroline O.Horner, Marina B. W.Oliveira, Glauce L.Germiniani, Bruno C.Teixeira, CristinaDuarte, RobsonAssef, Maria G. P. L.Rosso, DeorgelisBigolin, RodrigoVanzuita, RaquelPrado, Luiz F. A.Oliveira, Andre L. V.Reis, Diego L.Morais, Mirene O.Bastos, Rafael S.Santana, Hericalizandra S. R.Silva, Alline O.Cacau, Lucas A. P.Almeida, Marilia S.Canavessi, Hugo SchlebingerNogueira, Eduardo E. F.Pavia, Caio L. P.Araujo, Jose F.Lira, Jose A.Nienstedt, Esteban C.Smith, Thiago C.Romano, MarceloBarros, DaltonCosta, Andre F.Takahashi, LuziaWerneck, ViniciusFarran, JorgeHenriques, Lilian A.Miura, ClaudiaLopes, Renato D. [UNIFESP]Vendrame, Leticia S. [UNIFESP]Guimaraes, Helio P. [UNIFESP]Sandri, Priscila [UNIFESP]Galassi, Marcela S. [UNIFESP]Toufen, CarlosSantiago, Roberta R. S.Hirota, Adriana S.Park, MarceloAzevedo, Luciano C. P.Malbouison, Luiz M.Costa, Maristela C.Taniguchi, LeandroPompilio, Carlos E.Baruzzi, ClaudioAndrade, Ana H. V.Taira, Elisabete E.Taino, BrunoOliveira, Clezio S.Silva, Anselmo C.Isola, AlexandreRezende, EderlonRodrigues, Ricardo G.Rangel, Vivian P. L.Luzzi, SergioGiacomassi, Ivens W. S.Nassar, Antonio P.Souza, Ana R.Rahal, LucianaNunes, Andre L.Giannini, FabioMenescal, BrenaMorais, Jussara E. P.Toledo, DiogoMorsch, Rafaela D.Merluzzi, ThalitaAmorim, Denise S.Bastos, Ana C. A. G.Santos, Patricia L.Silva, Sabrina F.Gallego, Raquel C. N.Santos, Gheisa D.Tucci, MauroCosta, Ramon T.Santos, Lucio S.Demarzo, Sergio E.Schettino, Guilherme P. P.Suzuki, Vivian C.Patrocinio, Ana C. L.Martins, Mariana L.Passos, Denise B. V. G.Cappi, Sylas B.Goncalves, IranBorges, Marcos C.Lovato, WilsonTavares, Marcel V.Morales, DanielaMachado, Luis A. M. W.Torres, Franciele C. C.Gomes, Tania M.Cerantola, Rodrigo B.Góis, Aécio Flávio Teixeira de [UNIFESP]Marraccini, Thiago [UNIFESP]Margarida, Kathia [UNIFESP]Cavalcante, Eulalia [UNIFESP]Machado, Flavia R. [UNIFESP]Mazza, Bruno F. [UNIFESP]Rossetti Santana, Heloisa B. [UNIFESP]Mendez, Vanessa M. F. [UNIFESP]Xavier, Patricia A. [UNIFESP]Rabelo, Melina V. [UNIFESP]Schievano, Fabiana R. [UNIFESP]Pinto, Walkyria A. M. [UNIFESP]Francisco, Renata S. [UNIFESP]Ferreira, Elaine M. [UNIFESP]Silva, Dafne C. B. [UNIFESP]Arduini, Rodrigo G. [UNIFESP]Aldrighi, Jose R.Amaro, Andreson F.Conde, Katia A. P.Pereira, Cesar A.Tarkieltaub, ElcioOliver, Wilson R.Guadalupe, Erika G. L.Acerbi, Paulo S. C.Tomizuka, Carlos I.Oliveira, Tatiana A.Geha, Nadia N.Mecatti, Giovana C.Piovesan, Maysa Z. R.Salomao, Maria C.Moreno, Marcelo S.Orsatti, Vinicius N.Miranda, WhinitonRay, AlexandreGuerra, AndreBaptista Filho, Mario L. A.Ferreira, Firmino H.Viera Filho, EdesioCanzi, Regina A.Giuberti, Adriana F. T.Garcez, Melissa C. M.Pedro, A.Sala, Andrea D.Suguitani, Edmundo O.Kazue, PriscilaOliveira, Luiz R. C.Infantini, Rodrigo M.Carvalho, Fabricio R. T.Andrade, Lucia C.Santos, Thiago M.Carmona, Cesar V.Figueiredo, Luciana C.Falcao, AntonioDragosavak, DesankaNogueira Filho, WilsonLunardi, Maria C.Lago, RobertoGatti, CiroChiasso, Tatiana M.Santos, Grazielle O.Silva, Aline C. F.Araujo, Arthur C.Ornellas, Izadora B.Vieira, Vitor M.Hajjar, Ludhmila A.Figueiredo, Adelaide C.Damasceno, BrunaPizarro, CamiloHinestrosa, AlfredoGarcia L., Sandra M. C.Gonzalez C., OctavioDiaz S., EdgardRaineri, Santi M.Cortegiani, AndreaART InvestigatorsWriting Steering CommTrial Management TeamData Monitoring CommTrial Ctr2016-01-24T14:27:34Z2016-01-24T14:27:34Z2012-08-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14application/pdfhttp://dx.doi.org/10.1186/1745-6215-13-153Trials. London: Biomed Central Ltd, v. 13, 14 p., 2012.10.1186/1745-6215-13-153WOS000314100100001.pdf1745-6215http://repositorio.unifesp.br/handle/11600/35182WOS:000314100100001engTrialsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T14:09:02Zoai:repositorio.unifesp.br/:11600/35182Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T14:09:02Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
title |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
spellingShingle |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial Cavalcanti, Alexandre B. Acute respiratory distress syndrome Alveolar recruitment PEEP Mechanical ventilation Clinical trials Randomized |
title_short |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
title_full |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
title_fullStr |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
title_full_unstemmed |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
title_sort |
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial |
author |
Cavalcanti, Alexandre B. |
author_facet |
Cavalcanti, Alexandre B. Berwanger, Otavio Suzumura, Erica A. Amato, Marcelo B. P. Tallo, Fernando S. Rezende, Ederlon A. C. Telles, Jose M. M. Romano, Edson Guimaraes, Helio P. Regenga, Marisa M. Takahashi, Luzia N. Teixeira, Cassiano Oliveira, Roselaine P. Carvalho, Vitor O. Diaz-Quijano, Fredi A. Carvalho, Carlos R. R. Kodama, Alessandra A. Ribeiro, Gisele F. M. Abreu, Matheus O. Oliveira, Ivonaldo M. Guyatt, Gordon Ferguson, Niall Walter, Stephen Vasconcelos, Marcia O. M. Segundo, Valerio J. Ferraz, Iris L. Silva, Rosicley S. Oliveira Filho, Wilson de Silva, Nelson B. Heirel, Debora C. B. Takatani, Rodrigo R. Sousa Neto, Jefferson A. Neto, Jeronimo C. B. Almeida, Samara D. Chamy, Gauco Goncalves Neto, Graciliano J. L. Dias, Alysson P. Silva, Rozangela R. Tavares, Roberta C. Souza, Marcia L. V. D. Decio, Janaina C. Lima, Cyntia M. L. S. Ferreira Neto, Fleury Oliveira, Katia R. Dias, Polyana P. L. C. Brandao, Andre L. S. B. Ramos, Joroastro E. Vasconcelos, Paula T. Flores, Dimitri G. Pinheiro Filho, Gilvan R. Andrade, Isaac G. Martinez, Amadeu Franca, Gustavo G. P. Monteiro, Livia L. Correia, Emmanuel I. S. Ribeiro, Wagner Pereira, Antonio J. Andrade, Wandalvo Leite, Petronio A. Filgueira Feto, Jose E. Holanda, Marcelo A. Amorim, Fabio F. Margalho, Silviano B. Domingues, Sergio M. Ferreira, Claiton S. Ferreira, Cassia M. Rabelo, Livia A. Duarte, Juliana N. Lima, Fernando B. Kawaguchi, Ines A. L. Araujo Neto, Jose A. Maia, Marcelo O. Correa, Fabiano G. Ribeiro, Rubens A. B. Caser, Eliana Moreira, Cora L. C. B. Marcilino, Antonielen Falcao, Jansen G. Jesus, Karinne R. Tcherniakovisk, Leo Dutra, Victor G. Thompson, Marlus M. Piras, Claudio Giuberti, Jonas Silva, Albano S. Santos, Jose R. P. Potratz, Jorge L. Paula, Ludmila N. Bozi, Giovana G. Gomes, Bruno C. Vassallo, Paula F. Rocha, Edson P. Lima, Maria H. B. S. Ferreira, Denise M. Goncalves, Fernanda A. F. Pereira, Sheila A. Nobrega, Marciano S. Caixeta, Carlos R. Moraes, Ana P. P. Carvalho, Alexandre G. R. Alves, Janine D. Carvalho, Frederico B. Moreira, Fabiana B. R. Starling, Claudia M. Couto, Wivian A. D. Bitencourt, Wesley S. Peixoto, Daniela C. Carvalho, Ivana L. V. Silva, Silvangela G. A. Felizardo, Livia R. S. M. Magalhaes Nascimento, Francine J. Santos, Priscila J. C. D. Zanta, Camila C. Martins, Marcele F. Naves, Sergio A. Silva, Fabiano D. Laube, Gilberto Galvao, Endi L. Sousa, Marcelo F. Souza, Marcia M. F. Carvalho, Fernanda L. G. Bergo, Ricardo R. Rezende, Claudnei M. Tamazato, Edys Y. Sarat, Saturnino Campo Almeida, Patricia S. Gorski, Anthony G. Matsui, Mirna Eberhart Neto, Ervin Nomoto, Silmara H. Lima, Zildamara B. Inagaki, Alexandre S. Gil, Fernando S. U. Araujo, Mario F. A. Oliveira, Aline E. Correa, Tiago A. Mendonca, Angela Reis, Helder Carneiro, Saul R. Castanelo, Carlos Coelho, Edward Amaral, Karine A. E. H. Rego, Leila R. M. Cunha, Adenard F. C. Barra, Williams F. Carneiro, Mauricio Batista, Roseane A. Zoghbi, Karina K. Machado, Nelma J. N. Ferreira, Reinaldo Apoena, Pablo Leao, Rosangela M. Martins, Eliauria R. Oliveira, Marcelo E. Odir, Isaura Kleber, Wladimy Tavares, Daniele Araujo, Marcelo E. U. Brilhante, Yuzeth Nobrega Tavares, Daniele C. C. Kleber, Wladmy Carvalho, Waneska L. N. Winveler, Georgia F. P. Chagas Filho, Aldir Cavalcanti, Raphael Ali Grion, Cintia M. C. Reis, Andrezza T. J. B. Festti, Josiane Gimenez, Francielli M. P. Larangeira, Alexandre S. Cardoso, Lucienne T. Q. Mezzaroba, Ana L. Giancursi, Thiago S. Kauss, Ivanil A. M. Duarte, Pericles A. D. Tozo, Tatiane C. Peliser, Priscila Germano, Almir Gurgel, Sanderland J. T. Silva, Sandra R. B. Kuroda, Cristina M. Herek, Andrea Yamada, Sergio S. Schiavetto, Paulo M. Wysocki, Natacha Matsubara, Rosely R. Sales, Joao A. L. Laprovita, Maria P. Pena, Felipe M. Sa, Alexandre Vianna, Arthur Verdeal, Juan C. Martins, Gloria A. Salgado, Diamantino R. Coelho, Adalberto M. Coelho, Milena P. P. M. Morong, Aline S. Poquiriqui, Rodolfo M. B. Ferreira, Ana P. Lucena, Debora N. L. Marino, Nathalia F. Moreira, Monique A. Uratani, Cristiana C. S. Severino, Marta A. Silva, Patricia N. Medeiros, Luciana G. Chaves Filho, Francisco G. Guimaraes, Daniela M. Q. S. Rezende, Valeria M. C. Carbonell, Roberto C. C. Trindade, Renata S. Pellegrini, Jose A. S. Boniatti, Marcio M. Santos, Moreno C. Boldo, Rodrigo Oliveira, Vanessa M. Correa, Viviane M. Nedel, Wagner Schaich, Felipe Tagliari, Luciana Savi, Augusto Schulz, Luis F. Maccari, Juara G. Seeger, Gabriela M. Foernges, Rafael B. Rieder, Marcelo M. Becker, Daniel A. Broilo, Fabiano P. Schwarz, Patricia Alencastro, Andre Berto, Paula Backes, Fabiane Dias, Fernando S. Blattner, Clarissa Martins, Edna T. J. Scaglia, Nris C. Vieira, Silvia R. R. Prado, Karen F. Fialkow, Lea Franke, Cristiano Vieira, Debora F. V. B. Moraes, Rafael B. Marques, Leonardo S. Hopf, Joao L. S. Wawrzeniak, Iuri C. Rech, Tatiana H. Albuquerque, Regis B. Guerreiro, Marcio O. Teixeira, Luciano O. Macedo, Pedro L. Bainy, Marina P. Ferreira, Edgard V. Martins, Marcio A. Andrade, Luciana A. S. Machado, Fernando O. Burigo, Ana C. Pincelli, Mariangela Kretzer, Lara Maia, Israel S. Cordeiro, Rodrigo B. Westphal, Glauco Caldeira, Milton Cramer, Amanda S. Dadam, Michelli M. Barbosa, Pierry O. Brilenger, Caroline O. Horner, Marina B. W. Oliveira, Glauce L. Germiniani, Bruno C. Teixeira, Cristina Duarte, Robson Assef, Maria G. P. L. Rosso, Deorgelis Bigolin, Rodrigo Vanzuita, Raquel Prado, Luiz F. A. Oliveira, Andre L. V. Reis, Diego L. Morais, Mirene O. Bastos, Rafael S. Santana, Hericalizandra S. R. Silva, Alline O. Cacau, Lucas A. P. Almeida, Marilia S. Canavessi, Hugo Schlebinger Nogueira, Eduardo E. F. Pavia, Caio L. P. Araujo, Jose F. Lira, Jose A. Nienstedt, Esteban C. Smith, Thiago C. Romano, Marcelo Barros, Dalton Costa, Andre F. Takahashi, Luzia Werneck, Vinicius Farran, Jorge Henriques, Lilian A. Miura, Claudia Lopes, Renato D. [UNIFESP] Vendrame, Leticia S. [UNIFESP] Guimaraes, Helio P. [UNIFESP] Sandri, Priscila [UNIFESP] Galassi, Marcela S. [UNIFESP] Toufen, Carlos Santiago, Roberta R. S. Hirota, Adriana S. Park, Marcelo Azevedo, Luciano C. P. Malbouison, Luiz M. Costa, Maristela C. Taniguchi, Leandro Pompilio, Carlos E. Baruzzi, Claudio Andrade, Ana H. V. Taira, Elisabete E. Taino, Bruno Oliveira, Clezio S. Silva, Anselmo C. Isola, Alexandre Rezende, Ederlon Rodrigues, Ricardo G. Rangel, Vivian P. L. Luzzi, Sergio Giacomassi, Ivens W. S. Nassar, Antonio P. Souza, Ana R. Rahal, Luciana Nunes, Andre L. Giannini, Fabio Menescal, Brena Morais, Jussara E. P. Toledo, Diogo Morsch, Rafaela D. Merluzzi, Thalita Amorim, Denise S. Bastos, Ana C. A. G. Santos, Patricia L. Silva, Sabrina F. Gallego, Raquel C. N. Santos, Gheisa D. Tucci, Mauro Costa, Ramon T. Santos, Lucio S. Demarzo, Sergio E. Schettino, Guilherme P. P. Suzuki, Vivian C. Patrocinio, Ana C. L. Martins, Mariana L. Passos, Denise B. V. G. Cappi, Sylas B. Goncalves, Iran Borges, Marcos C. Lovato, Wilson Tavares, Marcel V. Morales, Daniela Machado, Luis A. M. W. Torres, Franciele C. C. Gomes, Tania M. Cerantola, Rodrigo B. Góis, Aécio Flávio Teixeira de [UNIFESP] Marraccini, Thiago [UNIFESP] Margarida, Kathia [UNIFESP] Cavalcante, Eulalia [UNIFESP] Machado, Flavia R. [UNIFESP] Mazza, Bruno F. [UNIFESP] Rossetti Santana, Heloisa B. [UNIFESP] Mendez, Vanessa M. F. [UNIFESP] Xavier, Patricia A. [UNIFESP] Rabelo, Melina V. [UNIFESP] Schievano, Fabiana R. [UNIFESP] Pinto, Walkyria A. M. [UNIFESP] Francisco, Renata S. [UNIFESP] Ferreira, Elaine M. [UNIFESP] Silva, Dafne C. B. [UNIFESP] Arduini, Rodrigo G. [UNIFESP] Aldrighi, Jose R. Amaro, Andreson F. Conde, Katia A. P. Pereira, Cesar A. Tarkieltaub, Elcio Oliver, Wilson R. Guadalupe, Erika G. L. Acerbi, Paulo S. C. Tomizuka, Carlos I. Oliveira, Tatiana A. Geha, Nadia N. Mecatti, Giovana C. Piovesan, Maysa Z. R. Salomao, Maria C. Moreno, Marcelo S. Orsatti, Vinicius N. Miranda, Whiniton Ray, Alexandre Guerra, Andre Baptista Filho, Mario L. A. Ferreira, Firmino H. Viera Filho, Edesio Canzi, Regina A. Giuberti, Adriana F. T. Garcez, Melissa C. M. Pedro, A. Sala, Andrea D. Suguitani, Edmundo O. Kazue, Priscila Oliveira, Luiz R. C. Infantini, Rodrigo M. Carvalho, Fabricio R. T. Andrade, Lucia C. Santos, Thiago M. Carmona, Cesar V. Figueiredo, Luciana C. Falcao, Antonio Dragosavak, Desanka Nogueira Filho, Wilson Lunardi, Maria C. Lago, Roberto Gatti, Ciro Chiasso, Tatiana M. Santos, Grazielle O. Silva, Aline C. F. Araujo, Arthur C. Ornellas, Izadora B. Vieira, Vitor M. Hajjar, Ludhmila A. Figueiredo, Adelaide C. Damasceno, Bruna Pizarro, Camilo Hinestrosa, Alfredo Garcia L., Sandra M. C. Gonzalez C., Octavio Diaz S., Edgard Raineri, Santi M. Cortegiani, Andrea ART Investigators Writing Steering Comm Trial Management Team Data Monitoring Comm Trial Ctr |
author_role |
author |
author2 |
Berwanger, Otavio Suzumura, Erica A. Amato, Marcelo B. P. Tallo, Fernando S. Rezende, Ederlon A. C. Telles, Jose M. M. Romano, Edson Guimaraes, Helio P. Regenga, Marisa M. Takahashi, Luzia N. Teixeira, Cassiano Oliveira, Roselaine P. Carvalho, Vitor O. Diaz-Quijano, Fredi A. Carvalho, Carlos R. R. Kodama, Alessandra A. Ribeiro, Gisele F. M. Abreu, Matheus O. Oliveira, Ivonaldo M. Guyatt, Gordon Ferguson, Niall Walter, Stephen Vasconcelos, Marcia O. M. Segundo, Valerio J. Ferraz, Iris L. Silva, Rosicley S. Oliveira Filho, Wilson de Silva, Nelson B. Heirel, Debora C. B. Takatani, Rodrigo R. Sousa Neto, Jefferson A. Neto, Jeronimo C. B. Almeida, Samara D. Chamy, Gauco Goncalves Neto, Graciliano J. L. Dias, Alysson P. Silva, Rozangela R. Tavares, Roberta C. Souza, Marcia L. V. D. Decio, Janaina C. Lima, Cyntia M. L. S. Ferreira Neto, Fleury Oliveira, Katia R. Dias, Polyana P. L. C. Brandao, Andre L. S. B. Ramos, Joroastro E. Vasconcelos, Paula T. Flores, Dimitri G. Pinheiro Filho, Gilvan R. Andrade, Isaac G. Martinez, Amadeu Franca, Gustavo G. P. Monteiro, Livia L. Correia, Emmanuel I. S. Ribeiro, Wagner Pereira, Antonio J. Andrade, Wandalvo Leite, Petronio A. Filgueira Feto, Jose E. Holanda, Marcelo A. Amorim, Fabio F. Margalho, Silviano B. Domingues, Sergio M. Ferreira, Claiton S. Ferreira, Cassia M. Rabelo, Livia A. Duarte, Juliana N. Lima, Fernando B. Kawaguchi, Ines A. L. Araujo Neto, Jose A. Maia, Marcelo O. Correa, Fabiano G. Ribeiro, Rubens A. B. Caser, Eliana Moreira, Cora L. C. B. Marcilino, Antonielen Falcao, Jansen G. Jesus, Karinne R. Tcherniakovisk, Leo Dutra, Victor G. Thompson, Marlus M. Piras, Claudio Giuberti, Jonas Silva, Albano S. Santos, Jose R. P. Potratz, Jorge L. Paula, Ludmila N. Bozi, Giovana G. Gomes, Bruno C. Vassallo, Paula F. Rocha, Edson P. Lima, Maria H. B. S. Ferreira, Denise M. Goncalves, Fernanda A. F. Pereira, Sheila A. Nobrega, Marciano S. Caixeta, Carlos R. Moraes, Ana P. P. Carvalho, Alexandre G. R. Alves, Janine D. Carvalho, Frederico B. Moreira, Fabiana B. R. Starling, Claudia M. Couto, Wivian A. D. Bitencourt, Wesley S. Peixoto, Daniela C. Carvalho, Ivana L. V. Silva, Silvangela G. A. Felizardo, Livia R. S. M. Magalhaes Nascimento, Francine J. Santos, Priscila J. C. D. Zanta, Camila C. Martins, Marcele F. Naves, Sergio A. Silva, Fabiano D. Laube, Gilberto Galvao, Endi L. Sousa, Marcelo F. Souza, Marcia M. F. Carvalho, Fernanda L. G. Bergo, Ricardo R. Rezende, Claudnei M. Tamazato, Edys Y. Sarat, Saturnino Campo Almeida, Patricia S. Gorski, Anthony G. Matsui, Mirna Eberhart Neto, Ervin Nomoto, Silmara H. Lima, Zildamara B. Inagaki, Alexandre S. Gil, Fernando S. U. Araujo, Mario F. A. Oliveira, Aline E. Correa, Tiago A. Mendonca, Angela Reis, Helder Carneiro, Saul R. Castanelo, Carlos Coelho, Edward Amaral, Karine A. E. H. Rego, Leila R. M. Cunha, Adenard F. C. Barra, Williams F. Carneiro, Mauricio Batista, Roseane A. Zoghbi, Karina K. Machado, Nelma J. N. Ferreira, Reinaldo Apoena, Pablo Leao, Rosangela M. Martins, Eliauria R. Oliveira, Marcelo E. Odir, Isaura Kleber, Wladimy Tavares, Daniele Araujo, Marcelo E. U. Brilhante, Yuzeth Nobrega Tavares, Daniele C. C. Kleber, Wladmy Carvalho, Waneska L. N. Winveler, Georgia F. P. Chagas Filho, Aldir Cavalcanti, Raphael Ali Grion, Cintia M. C. Reis, Andrezza T. J. B. Festti, Josiane Gimenez, Francielli M. P. Larangeira, Alexandre S. Cardoso, Lucienne T. Q. Mezzaroba, Ana L. Giancursi, Thiago S. Kauss, Ivanil A. M. Duarte, Pericles A. D. Tozo, Tatiane C. Peliser, Priscila Germano, Almir Gurgel, Sanderland J. T. Silva, Sandra R. B. Kuroda, Cristina M. Herek, Andrea Yamada, Sergio S. Schiavetto, Paulo M. Wysocki, Natacha Matsubara, Rosely R. Sales, Joao A. L. Laprovita, Maria P. Pena, Felipe M. Sa, Alexandre Vianna, Arthur Verdeal, Juan C. Martins, Gloria A. Salgado, Diamantino R. Coelho, Adalberto M. Coelho, Milena P. P. M. Morong, Aline S. Poquiriqui, Rodolfo M. B. Ferreira, Ana P. Lucena, Debora N. L. Marino, Nathalia F. Moreira, Monique A. Uratani, Cristiana C. S. Severino, Marta A. Silva, Patricia N. Medeiros, Luciana G. Chaves Filho, Francisco G. Guimaraes, Daniela M. Q. S. Rezende, Valeria M. C. Carbonell, Roberto C. C. Trindade, Renata S. Pellegrini, Jose A. S. Boniatti, Marcio M. Santos, Moreno C. Boldo, Rodrigo Oliveira, Vanessa M. Correa, Viviane M. Nedel, Wagner Schaich, Felipe Tagliari, Luciana Savi, Augusto Schulz, Luis F. Maccari, Juara G. Seeger, Gabriela M. Foernges, Rafael B. Rieder, Marcelo M. Becker, Daniel A. Broilo, Fabiano P. Schwarz, Patricia Alencastro, Andre Berto, Paula Backes, Fabiane Dias, Fernando S. Blattner, Clarissa Martins, Edna T. J. Scaglia, Nris C. Vieira, Silvia R. R. Prado, Karen F. Fialkow, Lea Franke, Cristiano Vieira, Debora F. V. B. Moraes, Rafael B. Marques, Leonardo S. Hopf, Joao L. S. Wawrzeniak, Iuri C. Rech, Tatiana H. Albuquerque, Regis B. Guerreiro, Marcio O. Teixeira, Luciano O. Macedo, Pedro L. Bainy, Marina P. Ferreira, Edgard V. Martins, Marcio A. Andrade, Luciana A. S. Machado, Fernando O. Burigo, Ana C. Pincelli, Mariangela Kretzer, Lara Maia, Israel S. Cordeiro, Rodrigo B. Westphal, Glauco Caldeira, Milton Cramer, Amanda S. Dadam, Michelli M. Barbosa, Pierry O. Brilenger, Caroline O. Horner, Marina B. W. Oliveira, Glauce L. Germiniani, Bruno C. Teixeira, Cristina Duarte, Robson Assef, Maria G. P. L. Rosso, Deorgelis Bigolin, Rodrigo Vanzuita, Raquel Prado, Luiz F. A. Oliveira, Andre L. V. Reis, Diego L. Morais, Mirene O. Bastos, Rafael S. Santana, Hericalizandra S. R. Silva, Alline O. Cacau, Lucas A. P. Almeida, Marilia S. Canavessi, Hugo Schlebinger Nogueira, Eduardo E. F. Pavia, Caio L. P. Araujo, Jose F. Lira, Jose A. Nienstedt, Esteban C. Smith, Thiago C. Romano, Marcelo Barros, Dalton Costa, Andre F. Takahashi, Luzia Werneck, Vinicius Farran, Jorge Henriques, Lilian A. Miura, Claudia Lopes, Renato D. [UNIFESP] Vendrame, Leticia S. [UNIFESP] Guimaraes, Helio P. [UNIFESP] Sandri, Priscila [UNIFESP] Galassi, Marcela S. [UNIFESP] Toufen, Carlos Santiago, Roberta R. S. Hirota, Adriana S. Park, Marcelo Azevedo, Luciano C. P. Malbouison, Luiz M. Costa, Maristela C. Taniguchi, Leandro Pompilio, Carlos E. Baruzzi, Claudio Andrade, Ana H. V. Taira, Elisabete E. Taino, Bruno Oliveira, Clezio S. Silva, Anselmo C. Isola, Alexandre Rezende, Ederlon Rodrigues, Ricardo G. Rangel, Vivian P. L. Luzzi, Sergio Giacomassi, Ivens W. S. Nassar, Antonio P. Souza, Ana R. Rahal, Luciana Nunes, Andre L. Giannini, Fabio Menescal, Brena Morais, Jussara E. P. Toledo, Diogo Morsch, Rafaela D. Merluzzi, Thalita Amorim, Denise S. Bastos, Ana C. A. G. Santos, Patricia L. Silva, Sabrina F. Gallego, Raquel C. N. Santos, Gheisa D. Tucci, Mauro Costa, Ramon T. Santos, Lucio S. Demarzo, Sergio E. Schettino, Guilherme P. P. Suzuki, Vivian C. Patrocinio, Ana C. L. Martins, Mariana L. Passos, Denise B. V. G. Cappi, Sylas B. Goncalves, Iran Borges, Marcos C. Lovato, Wilson Tavares, Marcel V. Morales, Daniela Machado, Luis A. M. W. Torres, Franciele C. C. Gomes, Tania M. Cerantola, Rodrigo B. Góis, Aécio Flávio Teixeira de [UNIFESP] Marraccini, Thiago [UNIFESP] Margarida, Kathia [UNIFESP] Cavalcante, Eulalia [UNIFESP] Machado, Flavia R. [UNIFESP] Mazza, Bruno F. [UNIFESP] Rossetti Santana, Heloisa B. [UNIFESP] Mendez, Vanessa M. F. [UNIFESP] Xavier, Patricia A. [UNIFESP] Rabelo, Melina V. [UNIFESP] Schievano, Fabiana R. [UNIFESP] Pinto, Walkyria A. M. [UNIFESP] Francisco, Renata S. [UNIFESP] Ferreira, Elaine M. [UNIFESP] Silva, Dafne C. B. [UNIFESP] Arduini, Rodrigo G. [UNIFESP] Aldrighi, Jose R. Amaro, Andreson F. Conde, Katia A. P. Pereira, Cesar A. Tarkieltaub, Elcio Oliver, Wilson R. Guadalupe, Erika G. L. Acerbi, Paulo S. C. Tomizuka, Carlos I. Oliveira, Tatiana A. Geha, Nadia N. Mecatti, Giovana C. Piovesan, Maysa Z. R. Salomao, Maria C. Moreno, Marcelo S. Orsatti, Vinicius N. Miranda, Whiniton Ray, Alexandre Guerra, Andre Baptista Filho, Mario L. A. Ferreira, Firmino H. Viera Filho, Edesio Canzi, Regina A. Giuberti, Adriana F. T. Garcez, Melissa C. M. Pedro, A. Sala, Andrea D. Suguitani, Edmundo O. Kazue, Priscila Oliveira, Luiz R. C. Infantini, Rodrigo M. Carvalho, Fabricio R. T. Andrade, Lucia C. Santos, Thiago M. Carmona, Cesar V. Figueiredo, Luciana C. Falcao, Antonio Dragosavak, Desanka Nogueira Filho, Wilson Lunardi, Maria C. Lago, Roberto Gatti, Ciro Chiasso, Tatiana M. Santos, Grazielle O. Silva, Aline C. F. Araujo, Arthur C. Ornellas, Izadora B. Vieira, Vitor M. Hajjar, Ludhmila A. Figueiredo, Adelaide C. Damasceno, Bruna Pizarro, Camilo Hinestrosa, Alfredo Garcia L., Sandra M. C. Gonzalez C., Octavio Diaz S., Edgard Raineri, Santi M. Cortegiani, Andrea ART Investigators Writing Steering Comm Trial Management Team Data Monitoring Comm Trial Ctr |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Hosp Urgencias & Emergencias Rio Branco HUERB Hosp & Pronto Socorro 28 Agosto UNIMED Manaus Fundacao Hosp Adriano Jorge Hosp Santa Izabel Santa Casa Misericordia Bahia Hosp Reg Juazeiro Gestao IMIP Hosp Univ Prof Edgar Santos Hosp Espanhol Hosp Geral Roberto Santos Hosp Messejana Hosp Reg Samambaia Hosp Reg Asa Norte HRAN Hosp Santa Luzia Hosp Santa Lucia Hosp Anchieta Ctr Integrado Atencao Saude CIAS Hosp Evangel Cachoeiro Itapemirin Vitoria Apart Hosp Vila Velha Hosp Hosp Clin UFES Hosp Clin UFG Hosp Geral Tarquinio Lopes Filho UDI Hosp Santa Casa Misericordia Ouro Preto Hosp Eduardo de Menezes Fundacao Hosp Sao Sebastiao Hosp Conego Monte Raso Hosp Municipal Odilon Behrens Hosp Sao Lucas Governador Valadares Santa Casa Caridade Diamantina Hosp Coracao Pocos de Caldas Hosp Reg Mato Grosso Sul Rosa Pedrossian Fundacao Univ Fed Grande Dourados Hosp Clin Gaspar Vianna Hosp Saude Mulher Fundacao Santa Casa Misericordia Para Hosp Emergencia Trauma Senador Humberto Lucena Hosp UNIMED Joao Pessoa Hosp Alfa Hosp Evangel Londrina Hosp Univ Reg Norte Parana Hosp Sao Lucas FAG Hosp Univ Reg Maringa Hosp Santa Casa Campo Mourao Hosp Santa Tereza Guarapuava Hosp Clin Padre Miguel Hosp Prontocardio Clin Sao Vicente Hosp Barra DOr Universidade Estadual de Maringá (UEM) Hosp Estadual & Pronto Socorro Joao Paulo II Hosp Geral Roraima Hosp Nossa Senhora Conceicao Hosp Moinhos Vento UTI Cent Irmandade Santa Casa Misericordia Porto UTI Pavilhao Pereira Filho Santa Casa Misericord Hosp Sao Lucas PUCRS Hosp Clin Porto Alegre HCPA Hosp Univ Sao Francisco Paula Hosp Coracao Universidade Federal de Santa Catarina (UFSC) Hosp Nereu Ramos Hosp UNIMED Joinville Hosp Sao Jose Hosp Reg Hans Dieter Schmidt Assoc Hosp & Maternidade Consul Carlos Renaux Hosp Primavera Hosp Urgencia Sergipe HUSE Hosp Coracao HCor Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Hosp Moyses Deutsch MBoi Mirim Hosp Servidor Publ Estadual Hosp & Maternidade Sao Camilo Hosp Sao Luiz AC Camargo Hosp Sirio Libanes Hosp Luz Hosp SaoLuiz Hosp & Maternidade Sao Cristovao Hosp Jose Soares Hungria Hosp Municipal Prof Doutor Alipio Correa Neto Hosp Univ Sao Francisco Hosp UNIMED Hosp Bandeirantes Hosp Geral Sao Mateus Dr Manoel Bifulco Inst Infectol Emilio Ribas Universidade Estadual de Campinas (UNICAMP) Hosp Clin Luzia de Pinho & Melo SPDM Inst Canc Estado São Paulo ICESP Hosp Maternidade UNIMED Leste Paulista Fdn Cardiovasc Colombia Los Comuneros Hosp Univ Bucaramanga Org Latinoamer Fomento Invest Salud OLFSI Medica Sur Azienda Osped Univ P Giaccone Hosp Coracao IEP HCor |
dc.contributor.author.fl_str_mv |
Cavalcanti, Alexandre B. Berwanger, Otavio Suzumura, Erica A. Amato, Marcelo B. P. Tallo, Fernando S. Rezende, Ederlon A. C. Telles, Jose M. M. Romano, Edson Guimaraes, Helio P. Regenga, Marisa M. Takahashi, Luzia N. Teixeira, Cassiano Oliveira, Roselaine P. Carvalho, Vitor O. Diaz-Quijano, Fredi A. Carvalho, Carlos R. R. Kodama, Alessandra A. Ribeiro, Gisele F. M. Abreu, Matheus O. Oliveira, Ivonaldo M. Guyatt, Gordon Ferguson, Niall Walter, Stephen Vasconcelos, Marcia O. M. Segundo, Valerio J. Ferraz, Iris L. Silva, Rosicley S. Oliveira Filho, Wilson de Silva, Nelson B. Heirel, Debora C. B. Takatani, Rodrigo R. Sousa Neto, Jefferson A. Neto, Jeronimo C. B. Almeida, Samara D. Chamy, Gauco Goncalves Neto, Graciliano J. L. Dias, Alysson P. Silva, Rozangela R. Tavares, Roberta C. Souza, Marcia L. V. D. Decio, Janaina C. Lima, Cyntia M. L. S. Ferreira Neto, Fleury Oliveira, Katia R. Dias, Polyana P. L. C. Brandao, Andre L. S. B. Ramos, Joroastro E. Vasconcelos, Paula T. Flores, Dimitri G. Pinheiro Filho, Gilvan R. Andrade, Isaac G. Martinez, Amadeu Franca, Gustavo G. P. Monteiro, Livia L. Correia, Emmanuel I. S. Ribeiro, Wagner Pereira, Antonio J. Andrade, Wandalvo Leite, Petronio A. Filgueira Feto, Jose E. Holanda, Marcelo A. Amorim, Fabio F. Margalho, Silviano B. Domingues, Sergio M. Ferreira, Claiton S. Ferreira, Cassia M. Rabelo, Livia A. Duarte, Juliana N. Lima, Fernando B. Kawaguchi, Ines A. L. Araujo Neto, Jose A. Maia, Marcelo O. Correa, Fabiano G. Ribeiro, Rubens A. B. Caser, Eliana Moreira, Cora L. C. B. Marcilino, Antonielen Falcao, Jansen G. Jesus, Karinne R. Tcherniakovisk, Leo Dutra, Victor G. Thompson, Marlus M. Piras, Claudio Giuberti, Jonas Silva, Albano S. Santos, Jose R. P. Potratz, Jorge L. Paula, Ludmila N. Bozi, Giovana G. Gomes, Bruno C. Vassallo, Paula F. Rocha, Edson P. Lima, Maria H. B. S. Ferreira, Denise M. Goncalves, Fernanda A. F. Pereira, Sheila A. Nobrega, Marciano S. Caixeta, Carlos R. Moraes, Ana P. P. Carvalho, Alexandre G. R. Alves, Janine D. Carvalho, Frederico B. Moreira, Fabiana B. R. Starling, Claudia M. Couto, Wivian A. D. Bitencourt, Wesley S. Peixoto, Daniela C. Carvalho, Ivana L. V. Silva, Silvangela G. A. Felizardo, Livia R. S. M. Magalhaes Nascimento, Francine J. Santos, Priscila J. C. D. Zanta, Camila C. Martins, Marcele F. Naves, Sergio A. Silva, Fabiano D. Laube, Gilberto Galvao, Endi L. Sousa, Marcelo F. Souza, Marcia M. F. Carvalho, Fernanda L. G. Bergo, Ricardo R. Rezende, Claudnei M. Tamazato, Edys Y. Sarat, Saturnino Campo Almeida, Patricia S. Gorski, Anthony G. Matsui, Mirna Eberhart Neto, Ervin Nomoto, Silmara H. Lima, Zildamara B. Inagaki, Alexandre S. Gil, Fernando S. U. Araujo, Mario F. A. Oliveira, Aline E. Correa, Tiago A. Mendonca, Angela Reis, Helder Carneiro, Saul R. Castanelo, Carlos Coelho, Edward Amaral, Karine A. E. H. Rego, Leila R. M. Cunha, Adenard F. C. Barra, Williams F. Carneiro, Mauricio Batista, Roseane A. Zoghbi, Karina K. Machado, Nelma J. N. Ferreira, Reinaldo Apoena, Pablo Leao, Rosangela M. Martins, Eliauria R. Oliveira, Marcelo E. Odir, Isaura Kleber, Wladimy Tavares, Daniele Araujo, Marcelo E. U. Brilhante, Yuzeth Nobrega Tavares, Daniele C. C. Kleber, Wladmy Carvalho, Waneska L. N. Winveler, Georgia F. P. Chagas Filho, Aldir Cavalcanti, Raphael Ali Grion, Cintia M. C. Reis, Andrezza T. J. B. Festti, Josiane Gimenez, Francielli M. P. Larangeira, Alexandre S. Cardoso, Lucienne T. Q. Mezzaroba, Ana L. Giancursi, Thiago S. Kauss, Ivanil A. M. Duarte, Pericles A. D. Tozo, Tatiane C. Peliser, Priscila Germano, Almir Gurgel, Sanderland J. T. Silva, Sandra R. B. Kuroda, Cristina M. Herek, Andrea Yamada, Sergio S. Schiavetto, Paulo M. Wysocki, Natacha Matsubara, Rosely R. Sales, Joao A. L. Laprovita, Maria P. Pena, Felipe M. Sa, Alexandre Vianna, Arthur Verdeal, Juan C. Martins, Gloria A. Salgado, Diamantino R. Coelho, Adalberto M. Coelho, Milena P. P. M. Morong, Aline S. Poquiriqui, Rodolfo M. B. Ferreira, Ana P. Lucena, Debora N. L. Marino, Nathalia F. Moreira, Monique A. Uratani, Cristiana C. S. Severino, Marta A. Silva, Patricia N. Medeiros, Luciana G. Chaves Filho, Francisco G. Guimaraes, Daniela M. Q. S. Rezende, Valeria M. C. Carbonell, Roberto C. C. Trindade, Renata S. Pellegrini, Jose A. S. Boniatti, Marcio M. Santos, Moreno C. Boldo, Rodrigo Oliveira, Vanessa M. Correa, Viviane M. Nedel, Wagner Schaich, Felipe Tagliari, Luciana Savi, Augusto Schulz, Luis F. Maccari, Juara G. Seeger, Gabriela M. Foernges, Rafael B. Rieder, Marcelo M. Becker, Daniel A. Broilo, Fabiano P. Schwarz, Patricia Alencastro, Andre Berto, Paula Backes, Fabiane Dias, Fernando S. Blattner, Clarissa Martins, Edna T. J. Scaglia, Nris C. Vieira, Silvia R. R. Prado, Karen F. Fialkow, Lea Franke, Cristiano Vieira, Debora F. V. B. Moraes, Rafael B. Marques, Leonardo S. Hopf, Joao L. S. Wawrzeniak, Iuri C. Rech, Tatiana H. Albuquerque, Regis B. Guerreiro, Marcio O. Teixeira, Luciano O. Macedo, Pedro L. Bainy, Marina P. Ferreira, Edgard V. Martins, Marcio A. Andrade, Luciana A. S. Machado, Fernando O. Burigo, Ana C. Pincelli, Mariangela Kretzer, Lara Maia, Israel S. Cordeiro, Rodrigo B. Westphal, Glauco Caldeira, Milton Cramer, Amanda S. Dadam, Michelli M. Barbosa, Pierry O. Brilenger, Caroline O. Horner, Marina B. W. Oliveira, Glauce L. Germiniani, Bruno C. Teixeira, Cristina Duarte, Robson Assef, Maria G. P. L. Rosso, Deorgelis Bigolin, Rodrigo Vanzuita, Raquel Prado, Luiz F. A. Oliveira, Andre L. V. Reis, Diego L. Morais, Mirene O. Bastos, Rafael S. Santana, Hericalizandra S. R. Silva, Alline O. Cacau, Lucas A. P. Almeida, Marilia S. Canavessi, Hugo Schlebinger Nogueira, Eduardo E. F. Pavia, Caio L. P. Araujo, Jose F. Lira, Jose A. Nienstedt, Esteban C. Smith, Thiago C. Romano, Marcelo Barros, Dalton Costa, Andre F. Takahashi, Luzia Werneck, Vinicius Farran, Jorge Henriques, Lilian A. Miura, Claudia Lopes, Renato D. [UNIFESP] Vendrame, Leticia S. [UNIFESP] Guimaraes, Helio P. [UNIFESP] Sandri, Priscila [UNIFESP] Galassi, Marcela S. [UNIFESP] Toufen, Carlos Santiago, Roberta R. S. Hirota, Adriana S. Park, Marcelo Azevedo, Luciano C. P. Malbouison, Luiz M. Costa, Maristela C. Taniguchi, Leandro Pompilio, Carlos E. Baruzzi, Claudio Andrade, Ana H. V. Taira, Elisabete E. Taino, Bruno Oliveira, Clezio S. Silva, Anselmo C. Isola, Alexandre Rezende, Ederlon Rodrigues, Ricardo G. Rangel, Vivian P. L. Luzzi, Sergio Giacomassi, Ivens W. S. Nassar, Antonio P. Souza, Ana R. Rahal, Luciana Nunes, Andre L. Giannini, Fabio Menescal, Brena Morais, Jussara E. P. Toledo, Diogo Morsch, Rafaela D. Merluzzi, Thalita Amorim, Denise S. Bastos, Ana C. A. G. Santos, Patricia L. Silva, Sabrina F. Gallego, Raquel C. N. Santos, Gheisa D. Tucci, Mauro Costa, Ramon T. Santos, Lucio S. Demarzo, Sergio E. Schettino, Guilherme P. P. Suzuki, Vivian C. Patrocinio, Ana C. L. Martins, Mariana L. Passos, Denise B. V. G. Cappi, Sylas B. Goncalves, Iran Borges, Marcos C. Lovato, Wilson Tavares, Marcel V. Morales, Daniela Machado, Luis A. M. W. Torres, Franciele C. C. Gomes, Tania M. Cerantola, Rodrigo B. Góis, Aécio Flávio Teixeira de [UNIFESP] Marraccini, Thiago [UNIFESP] Margarida, Kathia [UNIFESP] Cavalcante, Eulalia [UNIFESP] Machado, Flavia R. [UNIFESP] Mazza, Bruno F. [UNIFESP] Rossetti Santana, Heloisa B. [UNIFESP] Mendez, Vanessa M. F. [UNIFESP] Xavier, Patricia A. [UNIFESP] Rabelo, Melina V. [UNIFESP] Schievano, Fabiana R. [UNIFESP] Pinto, Walkyria A. M. [UNIFESP] Francisco, Renata S. [UNIFESP] Ferreira, Elaine M. [UNIFESP] Silva, Dafne C. B. [UNIFESP] Arduini, Rodrigo G. [UNIFESP] Aldrighi, Jose R. Amaro, Andreson F. Conde, Katia A. P. Pereira, Cesar A. Tarkieltaub, Elcio Oliver, Wilson R. Guadalupe, Erika G. L. Acerbi, Paulo S. C. Tomizuka, Carlos I. Oliveira, Tatiana A. Geha, Nadia N. Mecatti, Giovana C. Piovesan, Maysa Z. R. Salomao, Maria C. Moreno, Marcelo S. Orsatti, Vinicius N. Miranda, Whiniton Ray, Alexandre Guerra, Andre Baptista Filho, Mario L. A. Ferreira, Firmino H. Viera Filho, Edesio Canzi, Regina A. Giuberti, Adriana F. T. Garcez, Melissa C. M. Pedro, A. Sala, Andrea D. Suguitani, Edmundo O. Kazue, Priscila Oliveira, Luiz R. C. Infantini, Rodrigo M. Carvalho, Fabricio R. T. Andrade, Lucia C. Santos, Thiago M. Carmona, Cesar V. Figueiredo, Luciana C. Falcao, Antonio Dragosavak, Desanka Nogueira Filho, Wilson Lunardi, Maria C. Lago, Roberto Gatti, Ciro Chiasso, Tatiana M. Santos, Grazielle O. Silva, Aline C. F. Araujo, Arthur C. Ornellas, Izadora B. Vieira, Vitor M. Hajjar, Ludhmila A. Figueiredo, Adelaide C. Damasceno, Bruna Pizarro, Camilo Hinestrosa, Alfredo Garcia L., Sandra M. C. Gonzalez C., Octavio Diaz S., Edgard Raineri, Santi M. Cortegiani, Andrea ART Investigators Writing Steering Comm Trial Management Team Data Monitoring Comm Trial Ctr |
dc.subject.por.fl_str_mv |
Acute respiratory distress syndrome Alveolar recruitment PEEP Mechanical ventilation Clinical trials Randomized |
topic |
Acute respiratory distress syndrome Alveolar recruitment PEEP Mechanical ventilation Clinical trials Randomized |
description |
Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART).Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. the intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. in the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). in both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. the primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle.Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-28 2016-01-24T14:27:34Z 2016-01-24T14:27:34Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1745-6215-13-153 Trials. London: Biomed Central Ltd, v. 13, 14 p., 2012. 10.1186/1745-6215-13-153 WOS000314100100001.pdf 1745-6215 http://repositorio.unifesp.br/handle/11600/35182 WOS:000314100100001 |
url |
http://dx.doi.org/10.1186/1745-6215-13-153 http://repositorio.unifesp.br/handle/11600/35182 |
identifier_str_mv |
Trials. London: Biomed Central Ltd, v. 13, 14 p., 2012. 10.1186/1745-6215-13-153 WOS000314100100001.pdf 1745-6215 WOS:000314100100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Trials |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268412941041664 |