Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/33647 https://dx.doi.org/10.1016/j.echo.2011.01.013 |
Resumo: | Background: Although there is anatomopathologic evidence of atrial involvement in Chagas cardiomyopathy (CCM), the impact in left atrial (LA) function is unknown. the aim of this study was to evaluate LA function in patients with CCM with real-time three-dimensional echocardiography (RT3DE) and to compare it with patients with idiopathic dilated cardiomyopathy (DCM).Methods: A total of 30 patients with CCM, 30 patients with DCM, and 20 normal subjects used as the control group were studied. With the use of RT3DE, we measured LA maximum (maxLAV), minimum, and pre-atrial contraction volumes and calculated total and active LA emptying fractions.Results: Left ventricular ejection fraction and mitral regurgitation were similar in both groups. MaxLAV/m(2) was larger in the CCM group than in the DCM group (76.9 +/- 21.9 mL vs. 59.1 +/- 26.0 mL; P < .01), and both were significantly larger than in the control group (P < .01). Total LA emptying fraction was lower in the CCM group than in the DCM group (0.30 +/- 0.10 vs. 0.40 +/- 0.12; P < .01), and both were lower than in the control group (P = .01). Active LA emptying fraction was also lower in the CCM group than in the DCM group (0.22 +/- 0.09 vs. 0.28 +/- 0.11; P < .01), and both were lower than in the control group (P = .01). the E/e' ratio was higher in the CCM group than in the DCM group (21 +/- 10 vs. 15 +/- 6; P < .01), and both were greater than in the control group (P < .01). in a multiple regression model, the E/e' ratio was the only independent predictor of a worsening active LA emptying fraction.Conclusion: LA function is more compromised in patients with CCM than in patients with DCM. This finding indicates a more diffuse and severe myocardial impairment in Chagas disease that is probably related to increased left ventricular filling pressures and atrial myopathy. (J Am Soc Echocardiogr 2011;24:526-32.) |
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Mancuso, Frederico José Neves [UNIFESP]Almeida, Dirceu Rodrigues de [UNIFESP]Moisés, Valdir Ambrósio [UNIFESP]Oliveira, Wercules Antonio [UNIFESP]Mello, Eduardo S. [UNIFESP]Poyares, Dalva [UNIFESP]Tufik, Sergio [UNIFESP]Carvalho, Antonio Carlos [UNIFESP]Campos, Orlando [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:06:26Z2016-01-24T14:06:26Z2011-05-01Journal of the American Society of Echocardiography. New York: Mosby-Elsevier, v. 24, n. 5, p. 526-532, 2011.0894-7317https://repositorio.unifesp.br/handle/11600/33647https://dx.doi.org/10.1016/j.echo.2011.01.01310.1016/j.echo.2011.01.013WOS:000289779500008Background: Although there is anatomopathologic evidence of atrial involvement in Chagas cardiomyopathy (CCM), the impact in left atrial (LA) function is unknown. the aim of this study was to evaluate LA function in patients with CCM with real-time three-dimensional echocardiography (RT3DE) and to compare it with patients with idiopathic dilated cardiomyopathy (DCM).Methods: A total of 30 patients with CCM, 30 patients with DCM, and 20 normal subjects used as the control group were studied. With the use of RT3DE, we measured LA maximum (maxLAV), minimum, and pre-atrial contraction volumes and calculated total and active LA emptying fractions.Results: Left ventricular ejection fraction and mitral regurgitation were similar in both groups. MaxLAV/m(2) was larger in the CCM group than in the DCM group (76.9 +/- 21.9 mL vs. 59.1 +/- 26.0 mL; P < .01), and both were significantly larger than in the control group (P < .01). Total LA emptying fraction was lower in the CCM group than in the DCM group (0.30 +/- 0.10 vs. 0.40 +/- 0.12; P < .01), and both were lower than in the control group (P = .01). Active LA emptying fraction was also lower in the CCM group than in the DCM group (0.22 +/- 0.09 vs. 0.28 +/- 0.11; P < .01), and both were lower than in the control group (P = .01). the E/e' ratio was higher in the CCM group than in the DCM group (21 +/- 10 vs. 15 +/- 6; P < .01), and both were greater than in the control group (P < .01). in a multiple regression model, the E/e' ratio was the only independent predictor of a worsening active LA emptying fraction.Conclusion: LA function is more compromised in patients with CCM than in patients with DCM. This finding indicates a more diffuse and severe myocardial impairment in Chagas disease that is probably related to increased left ventricular filling pressures and atrial myopathy. (J Am Soc Echocardiogr 2011;24:526-32.)Universidade Federal de São Paulo, Dept Internal Med, Discipline Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, Discipline Sleep Biol & Med, Dept Psychobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Internal Med, Discipline Cardiol, São Paulo, BrazilUniversidade Federal de São Paulo, Discipline Sleep Biol & Med, Dept Psychobiol, São Paulo, BrazilWeb of Science526-532engElsevier B.V.Journal of the American Society of Echocardiographyhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessCardiomyopathyChagas diseaseLeft atriumReal-time three-dimensional echocardiographyLeft Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiographyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/336472023-04-27 19:14:39.974metadata only accessoai:repositorio.unifesp.br:11600/33647Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:40.054401Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
title |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
spellingShingle |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography Mancuso, Frederico José Neves [UNIFESP] Cardiomyopathy Chagas disease Left atrium Real-time three-dimensional echocardiography |
title_short |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
title_full |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
title_fullStr |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
title_full_unstemmed |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
title_sort |
Left Atrial Dysfunction in Chagas Cardiomyopathy Is More Severe Than in Idiopathic Dilated Cardiomyopathy: A Study with Real-Time Three-Dimensional Echocardiography |
author |
Mancuso, Frederico José Neves [UNIFESP] |
author_facet |
Mancuso, Frederico José Neves [UNIFESP] Almeida, Dirceu Rodrigues de [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] Oliveira, Wercules Antonio [UNIFESP] Mello, Eduardo S. [UNIFESP] Poyares, Dalva [UNIFESP] Tufik, Sergio [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Campos, Orlando [UNIFESP] |
author_role |
author |
author2 |
Almeida, Dirceu Rodrigues de [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] Oliveira, Wercules Antonio [UNIFESP] Mello, Eduardo S. [UNIFESP] Poyares, Dalva [UNIFESP] Tufik, Sergio [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Campos, Orlando [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Mancuso, Frederico José Neves [UNIFESP] Almeida, Dirceu Rodrigues de [UNIFESP] Moisés, Valdir Ambrósio [UNIFESP] Oliveira, Wercules Antonio [UNIFESP] Mello, Eduardo S. [UNIFESP] Poyares, Dalva [UNIFESP] Tufik, Sergio [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Campos, Orlando [UNIFESP] |
dc.subject.eng.fl_str_mv |
Cardiomyopathy Chagas disease Left atrium Real-time three-dimensional echocardiography |
topic |
Cardiomyopathy Chagas disease Left atrium Real-time three-dimensional echocardiography |
description |
Background: Although there is anatomopathologic evidence of atrial involvement in Chagas cardiomyopathy (CCM), the impact in left atrial (LA) function is unknown. the aim of this study was to evaluate LA function in patients with CCM with real-time three-dimensional echocardiography (RT3DE) and to compare it with patients with idiopathic dilated cardiomyopathy (DCM).Methods: A total of 30 patients with CCM, 30 patients with DCM, and 20 normal subjects used as the control group were studied. With the use of RT3DE, we measured LA maximum (maxLAV), minimum, and pre-atrial contraction volumes and calculated total and active LA emptying fractions.Results: Left ventricular ejection fraction and mitral regurgitation were similar in both groups. MaxLAV/m(2) was larger in the CCM group than in the DCM group (76.9 +/- 21.9 mL vs. 59.1 +/- 26.0 mL; P < .01), and both were significantly larger than in the control group (P < .01). Total LA emptying fraction was lower in the CCM group than in the DCM group (0.30 +/- 0.10 vs. 0.40 +/- 0.12; P < .01), and both were lower than in the control group (P = .01). Active LA emptying fraction was also lower in the CCM group than in the DCM group (0.22 +/- 0.09 vs. 0.28 +/- 0.11; P < .01), and both were lower than in the control group (P = .01). the E/e' ratio was higher in the CCM group than in the DCM group (21 +/- 10 vs. 15 +/- 6; P < .01), and both were greater than in the control group (P < .01). in a multiple regression model, the E/e' ratio was the only independent predictor of a worsening active LA emptying fraction.Conclusion: LA function is more compromised in patients with CCM than in patients with DCM. This finding indicates a more diffuse and severe myocardial impairment in Chagas disease that is probably related to increased left ventricular filling pressures and atrial myopathy. (J Am Soc Echocardiogr 2011;24:526-32.) |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:06:26Z |
dc.date.available.fl_str_mv |
2016-01-24T14:06:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of the American Society of Echocardiography. New York: Mosby-Elsevier, v. 24, n. 5, p. 526-532, 2011. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/33647 https://dx.doi.org/10.1016/j.echo.2011.01.013 |
dc.identifier.issn.none.fl_str_mv |
0894-7317 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.echo.2011.01.013 |
dc.identifier.wos.none.fl_str_mv |
WOS:000289779500008 |
identifier_str_mv |
Journal of the American Society of Echocardiography. New York: Mosby-Elsevier, v. 24, n. 5, p. 526-532, 2011. 0894-7317 10.1016/j.echo.2011.01.013 WOS:000289779500008 |
url |
https://repositorio.unifesp.br/handle/11600/33647 https://dx.doi.org/10.1016/j.echo.2011.01.013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of the American Society of Echocardiography |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
526-532 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460268835078144 |