Evaluation of P53, E-cadherin, Cox-2, and EGFR proteinimunnoexpression on prognostic of resected gallbladder carcinoma

• Autor(a) principal: Pais-costa, Sergio Renato
• Data de Publicação: 2014
• Outros Autores: Farah, José Francisco De Matos, Artigiani Neto, Ricardo [UNIFESP], Martins, Sandro José, Goldenberg, Alberto [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0102-67202014000200009; http://repositorio.unifesp.br/handle/11600/8427
• topic: Billiary neoplasms; Adenocarcinoma; Tumor biological markers; Antígens CD; Prognosis; Neoplasias biliares; Adenocarcinoma; Marcadores biológicos de tumor; Antígenos CD; Prognóstico

BACKGROUND: Gallbladder carcinoma presents a dismal prognosis. Choice treatment is surgical resection that is associated a high levels of both morbidity and mortality. Best knowledgement of prognostic factors may result a better selection of patient either for surgical or multimodal treatment. AIM: To evaluate tecidual immunoexpression of P53, E-cadherin, Cox-2, and EGFR proteins and to correlate these findings with resected gallbladder adenocarcinoma survival. METHODS: Clinical, laboratorial, surgical, and anatomopathological reports of a series of gallbladder adenocarcinoma patients were collected by individualized questionary. Total sample was 42 patients. Median of age was 72 years (35-87). There were seven men and 35 women. Lesion distribuition in according TNM state was the following: T1 (n=2), T2 (n=5), T3 (n=31), T4 (n=4). Twenty-three patients underwent radical resection (R0), while 19 palliative surgery (R1-R2). A block of tissue microarray with neoplasic tissue of each patient was confected. It was performed evaluation of P53, E-Caderine, COX-2, and EGFR proteins imunoexpression. These findings were correlated with overall survival. RESULTS: Five-year survival was 28%. The median of global survival was eight months. Only immunoexpression of EGFR protein was considered independent variable at multivariated analysis. CONCLUSION: Final prognosis was influenced by over-expression of EGFR protein in tumoral tissue.