Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33219 http://dx.doi.org/10.1590/S0102-695X2011005000019 |
Resumo: | The objective of the present study was to assess whether Turnera diffusa Willd. ex Schult., Turneraceae, (TD), plant known in popular medicine as tonic and aphrodisiac, has other effects that are characteristic of an adaptogen substance, such as improvement of the memory and reduction of the damage caused by stress. We carried out an initial screening to detect a possible toxicity of the plant. in that phase of the study we used tests of observational screening; evaluation of acute toxicity; measurement of motor activity and motor coordination, and sleeping time induced by pentobarbital, and observed that the extract presented low toxicity and no stimulant or depressant effect on the animals. We then performed specific tests for the evaluation of an adaptogen effect. TD did not protect the stomach of the animals from the formation of ulcers, neither did it alter the plasmatic levels of adrenocorticotropic hormone (ACTH) and corticosterone of the animals submitted to immobilization and cold. As regards the evaluation of memory in passive avoidance, TD did not inhibit scopolamine-induced amnesia. Additionally, the hydroalcoholic extract presented low antioxidant activity in vitro. in the models used, TD produced no changes in relation to a possible adaptogen effect. |
id |
UFSP_a6893aff5af86a610cb5c3359bf691a6 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/33219 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Bezerra, Andreia Gomes [UNIFESP]Mendes, Fulvio R. [UNIFESP]Tabach, Ricardo [UNIFESP]Carlini, Elisaldo A. [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:05:53Z2016-01-24T14:05:53Z2011-01-01Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Joao Pessoa: Soc Brasileira Farmacognosia, v. 21, n. 1, p. 121-127, 2011.0102-695Xhttp://repositorio.unifesp.br/handle/11600/33219http://dx.doi.org/10.1590/S0102-695X2011005000019S0102-695X201100500001910.1590/S0102-695X2011005000019WOS:000289152900020The objective of the present study was to assess whether Turnera diffusa Willd. ex Schult., Turneraceae, (TD), plant known in popular medicine as tonic and aphrodisiac, has other effects that are characteristic of an adaptogen substance, such as improvement of the memory and reduction of the damage caused by stress. We carried out an initial screening to detect a possible toxicity of the plant. in that phase of the study we used tests of observational screening; evaluation of acute toxicity; measurement of motor activity and motor coordination, and sleeping time induced by pentobarbital, and observed that the extract presented low toxicity and no stimulant or depressant effect on the animals. We then performed specific tests for the evaluation of an adaptogen effect. TD did not protect the stomach of the animals from the formation of ulcers, neither did it alter the plasmatic levels of adrenocorticotropic hormone (ACTH) and corticosterone of the animals submitted to immobilization and cold. As regards the evaluation of memory in passive avoidance, TD did not inhibit scopolamine-induced amnesia. Additionally, the hydroalcoholic extract presented low antioxidant activity in vitro. in the models used, TD produced no changes in relation to a possible adaptogen effect.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CebridAfipUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilWeb of Science121-127engSoc Brasileira FarmacognosiaRevista Brasileira de Farmacognosia-brazilian Journal of PharmacognosyTurnera diffusaadaptogenstoxicitystressmemoryantioxidantEffects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0102-695X2011000100020.pdfS0102-695X2011000100020.pdfapplication/pdf795492${dspace.ui.url}/bitstream/11600/33219/1/S0102-695X2011000100020.pdf3e518835088adb27127b930895c3d0bfMD51metadata only access11600/332192022-11-04 15:08:28.377metadata only accessoai:repositorio.unifesp.br:11600/33219Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T18:08:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
title |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
spellingShingle |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity Bezerra, Andreia Gomes [UNIFESP] Turnera diffusa adaptogens toxicity stress memory antioxidant |
title_short |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
title_full |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
title_fullStr |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
title_full_unstemmed |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
title_sort |
Effects of a hydroalcoholic extract of Turnera diffusa in tests for adaptogenic activity |
author |
Bezerra, Andreia Gomes [UNIFESP] |
author_facet |
Bezerra, Andreia Gomes [UNIFESP] Mendes, Fulvio R. [UNIFESP] Tabach, Ricardo [UNIFESP] Carlini, Elisaldo A. [UNIFESP] |
author_role |
author |
author2 |
Mendes, Fulvio R. [UNIFESP] Tabach, Ricardo [UNIFESP] Carlini, Elisaldo A. [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Bezerra, Andreia Gomes [UNIFESP] Mendes, Fulvio R. [UNIFESP] Tabach, Ricardo [UNIFESP] Carlini, Elisaldo A. [UNIFESP] |
dc.subject.eng.fl_str_mv |
Turnera diffusa adaptogens toxicity stress memory antioxidant |
topic |
Turnera diffusa adaptogens toxicity stress memory antioxidant |
description |
The objective of the present study was to assess whether Turnera diffusa Willd. ex Schult., Turneraceae, (TD), plant known in popular medicine as tonic and aphrodisiac, has other effects that are characteristic of an adaptogen substance, such as improvement of the memory and reduction of the damage caused by stress. We carried out an initial screening to detect a possible toxicity of the plant. in that phase of the study we used tests of observational screening; evaluation of acute toxicity; measurement of motor activity and motor coordination, and sleeping time induced by pentobarbital, and observed that the extract presented low toxicity and no stimulant or depressant effect on the animals. We then performed specific tests for the evaluation of an adaptogen effect. TD did not protect the stomach of the animals from the formation of ulcers, neither did it alter the plasmatic levels of adrenocorticotropic hormone (ACTH) and corticosterone of the animals submitted to immobilization and cold. As regards the evaluation of memory in passive avoidance, TD did not inhibit scopolamine-induced amnesia. Additionally, the hydroalcoholic extract presented low antioxidant activity in vitro. in the models used, TD produced no changes in relation to a possible adaptogen effect. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:05:53Z |
dc.date.available.fl_str_mv |
2016-01-24T14:05:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Joao Pessoa: Soc Brasileira Farmacognosia, v. 21, n. 1, p. 121-127, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33219 http://dx.doi.org/10.1590/S0102-695X2011005000019 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.scielo.none.fl_str_mv |
S0102-695X2011005000019 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-695X2011005000019 |
dc.identifier.wos.none.fl_str_mv |
WOS:000289152900020 |
identifier_str_mv |
Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Joao Pessoa: Soc Brasileira Farmacognosia, v. 21, n. 1, p. 121-127, 2011. 0102-695X S0102-695X2011005000019 10.1590/S0102-695X2011005000019 WOS:000289152900020 |
url |
http://repositorio.unifesp.br/handle/11600/33219 http://dx.doi.org/10.1590/S0102-695X2011005000019 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
121-127 |
dc.publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
publisher.none.fl_str_mv |
Soc Brasileira Farmacognosia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/33219/1/S0102-695X2011000100020.pdf |
bitstream.checksum.fl_str_mv |
3e518835088adb27127b930895c3d0bf |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764184239210496 |