Response of the lung after pneumonectomy in alloxan diabetic rats

Detalhes bibliográficos
Autor(a) principal: Seidel, Amélia Cristina [UNIFESP]
Data de Publicação: 2003
Outros Autores: Fagundes, Djalma José [UNIFESP], Novo, Neil Ferreira [UNIFESP], Juliano, Yara [UNIFESP], Meister, Hugo, Bazotte, Roberto Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1516-89132003000200012
http://repositorio.unifesp.br/handle/11600/1674
Resumo: In order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.
id UFSP_a7bde056a5d77b23083a9a495bd8cf19
oai_identifier_str oai:repositorio.unifesp.br/:11600/1674
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Response of the lung after pneumonectomy in alloxan diabetic ratsExperimental diabetesAlloxanPneumonectomyLung growthRatsSurgeryIn order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.Nosso objetivo foi investigar a resposta do pulmão remanescente à pneumonectomia. Para alcançar este propósito, ratas da linhagem Wistar receberam uma injeção intraperitoneal de aloxana (Grupo D) ou salina (Grupo C). Seis dias após a administração de aloxana (45 mg/kg) o diabetes mellitus foi confirmado e os animais aleatoriamente distribuídos em 3 subgrupos: não operados, falsamente operados e submetidos a pneumonectomia. Trinta e seis dias após a cirurgia os animais foram sacrificados e o peso e volume dos pulmões avaliados. Animais diabéticos pneumonectomizados apresentaram menor volume e peso pulmonar em relação a animais não diabéticos pneumonectomizados. Assim, os resultados demonstraram que o crescimento pulmonar compensatório que ocorre após a pneumonectomia não foi observado em animais diabéticos.Universidade Estadual de Maringá Departamento de MedicinaUniversidade Federal de São Paulo (UNIFESP) Departamento de CirurgiaUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina PreventivaUniversidade Estadual de Maringá Departamento de Farmácia e FarmacologiaUNIFESP, Depto. de CirurgiaUNIFESP, Depto. de Medicina PreventivaSciELOInstituto de Tecnologia do Paraná - TecparUniversidade Estadual de Maringá Departamento de MedicinaUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual de Maringá Departamento de Farmácia e FarmacologiaSeidel, Amélia Cristina [UNIFESP]Fagundes, Djalma José [UNIFESP]Novo, Neil Ferreira [UNIFESP]Juliano, Yara [UNIFESP]Meister, HugoBazotte, Roberto Barbosa2015-06-14T13:29:57Z2015-06-14T13:29:57Z2003-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion211-214application/pdfhttp://dx.doi.org/10.1590/S1516-89132003000200012Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 46, n. 2, p. 211-214, 2003.10.1590/S1516-89132003000200012S1516-89132003000200012.pdf1516-8913S1516-89132003000200012http://repositorio.unifesp.br/handle/11600/1674WOS:000183645600012engBrazilian Archives of Biology and Technologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T08:14:39Zoai:repositorio.unifesp.br/:11600/1674Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T08:14:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Response of the lung after pneumonectomy in alloxan diabetic rats
title Response of the lung after pneumonectomy in alloxan diabetic rats
spellingShingle Response of the lung after pneumonectomy in alloxan diabetic rats
Seidel, Amélia Cristina [UNIFESP]
Experimental diabetes
Alloxan
Pneumonectomy
Lung growth
Rats
Surgery
title_short Response of the lung after pneumonectomy in alloxan diabetic rats
title_full Response of the lung after pneumonectomy in alloxan diabetic rats
title_fullStr Response of the lung after pneumonectomy in alloxan diabetic rats
title_full_unstemmed Response of the lung after pneumonectomy in alloxan diabetic rats
title_sort Response of the lung after pneumonectomy in alloxan diabetic rats
author Seidel, Amélia Cristina [UNIFESP]
author_facet Seidel, Amélia Cristina [UNIFESP]
Fagundes, Djalma José [UNIFESP]
Novo, Neil Ferreira [UNIFESP]
Juliano, Yara [UNIFESP]
Meister, Hugo
Bazotte, Roberto Barbosa
author_role author
author2 Fagundes, Djalma José [UNIFESP]
Novo, Neil Ferreira [UNIFESP]
Juliano, Yara [UNIFESP]
Meister, Hugo
Bazotte, Roberto Barbosa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Maringá Departamento de Medicina
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia
dc.contributor.author.fl_str_mv Seidel, Amélia Cristina [UNIFESP]
Fagundes, Djalma José [UNIFESP]
Novo, Neil Ferreira [UNIFESP]
Juliano, Yara [UNIFESP]
Meister, Hugo
Bazotte, Roberto Barbosa
dc.subject.por.fl_str_mv Experimental diabetes
Alloxan
Pneumonectomy
Lung growth
Rats
Surgery
topic Experimental diabetes
Alloxan
Pneumonectomy
Lung growth
Rats
Surgery
description In order to determine the response of remaining lung after pneumonectomy during diabetes, female Wistar rats that received an intraperitoneal injection of alloxan (D Group) or saline (C Group) were submitted to lung resection. Six days after alloxan injection (45 mg/kg), diabetes was confirmed. The rats were randomized divided in 3 subgroups: non-operated (NO), sham operation (SO) and left pneumonectomy (PE). Thirty days after the surgery all rats were killed and the weight and volume of the lungs were measured. PE-diabetic rats showed smaller lung weight and volume than PE-non-diabetic animals. The results demonstrated that the compensatory lung growth postpneumonectomy were not observed in diabetic rats.
publishDate 2003
dc.date.none.fl_str_mv 2003-03-01
2015-06-14T13:29:57Z
2015-06-14T13:29:57Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-89132003000200012
Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 46, n. 2, p. 211-214, 2003.
10.1590/S1516-89132003000200012
S1516-89132003000200012.pdf
1516-8913
S1516-89132003000200012
http://repositorio.unifesp.br/handle/11600/1674
WOS:000183645600012
url http://dx.doi.org/10.1590/S1516-89132003000200012
http://repositorio.unifesp.br/handle/11600/1674
identifier_str_mv Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 46, n. 2, p. 211-214, 2003.
10.1590/S1516-89132003000200012
S1516-89132003000200012.pdf
1516-8913
S1516-89132003000200012
WOS:000183645600012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Archives of Biology and Technology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 211-214
application/pdf
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268370290212864

Registros relacionados