Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance

Detalhes bibliográficos
Autor(a) principal: Sallorenzo, Carolina [UNIFESP]
Data de Publicação: 2017
Outros Autores: Silva, Regina [UNIFESP], Kasamatsu, Teresa [UNIFESP], Dib, Sergio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/2359-3997000000280
https://repositorio.unifesp.br/handle/11600/53496
Resumo: Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD
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spelling Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose toleranceAutoimmune thyroid diseasepancreatic autoantibodiesglucose tolerancebeta-cell functionObjective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GDn = 181) and Hashimoto's thyroiditis (HTn = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients. Results: There was a non significant trend for higher prevalence of GADA positivity in GD vs HT (7.2% vs 2% p = 0.06), but the GADA titers were higher in HT. We also did not find a significant difference in IA2 prevalence (0.7% vs 0.0%) between these two groups or compared to the control group. In the subsequent analysis, low FPIR was found in 10% of these patients but without statistical difference for OGTT between pancreatic antibody-positive and -negative patients. Conclusion: A trend for greater prevalence of GADA was observed for GD patients than for HT or control. However, the titers of these autoantibodies were higher in HT patients, but there was no significant relation to insulin secretion and glucose tolerance at that moment and stage of autoimmune diseases.Univ Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, BrazilWeb of ScienceCNPq, BrazilCNPq: 133045/2001-3Sbem-Soc Brasil Endocrinologia & Metabologia2020-06-26T16:30:21Z2020-06-26T16:30:21Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion361-366application/pdfhttp://dx.doi.org/10.1590/2359-3997000000280Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017.10.1590/2359-3997000000280S2359-39972017000400361.pdf2359-3997S2359-39972017000400361https://repositorio.unifesp.br/handle/11600/53496WOS:000416003200010engArchives Of Endocrinology MetabolismRio De Janeiro, Rjinfo:eu-repo/semantics/openAccessSallorenzo, Carolina [UNIFESP]Silva, Regina [UNIFESP]Kasamatsu, Teresa [UNIFESP]Dib, Sergio [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T03:41:29Zoai:repositorio.unifesp.br/:11600/53496Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T03:41:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
title Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
spellingShingle Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
Sallorenzo, Carolina [UNIFESP]
Autoimmune thyroid disease
pancreatic autoantibodies
glucose tolerance
beta-cell function
title_short Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
title_full Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
title_fullStr Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
title_full_unstemmed Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
title_sort Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
author Sallorenzo, Carolina [UNIFESP]
author_facet Sallorenzo, Carolina [UNIFESP]
Silva, Regina [UNIFESP]
Kasamatsu, Teresa [UNIFESP]
Dib, Sergio [UNIFESP]
author_role author
author2 Silva, Regina [UNIFESP]
Kasamatsu, Teresa [UNIFESP]
Dib, Sergio [UNIFESP]
author2_role author
author
author
dc.contributor.author.fl_str_mv Sallorenzo, Carolina [UNIFESP]
Silva, Regina [UNIFESP]
Kasamatsu, Teresa [UNIFESP]
Dib, Sergio [UNIFESP]
dc.subject.por.fl_str_mv Autoimmune thyroid disease
pancreatic autoantibodies
glucose tolerance
beta-cell function
topic Autoimmune thyroid disease
pancreatic autoantibodies
glucose tolerance
beta-cell function
description Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-06-26T16:30:21Z
2020-06-26T16:30:21Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/2359-3997000000280
Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017.
10.1590/2359-3997000000280
S2359-39972017000400361.pdf
2359-3997
S2359-39972017000400361
https://repositorio.unifesp.br/handle/11600/53496
WOS:000416003200010
url http://dx.doi.org/10.1590/2359-3997000000280
https://repositorio.unifesp.br/handle/11600/53496
identifier_str_mv Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017.
10.1590/2359-3997000000280
S2359-39972017000400361.pdf
2359-3997
S2359-39972017000400361
WOS:000416003200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Archives Of Endocrinology Metabolism
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 361-366
application/pdf
dc.coverage.none.fl_str_mv Rio De Janeiro, Rj
dc.publisher.none.fl_str_mv Sbem-Soc Brasil Endocrinologia & Metabologia
publisher.none.fl_str_mv Sbem-Soc Brasil Endocrinologia & Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268420987813888

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