Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/2359-3997000000280 https://repositorio.unifesp.br/handle/11600/53496 |
Resumo: | Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD |
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Repositório Institucional da UNIFESP |
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3465 |
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Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose toleranceAutoimmune thyroid diseasepancreatic autoantibodiesglucose tolerancebeta-cell functionObjective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GDn = 181) and Hashimoto's thyroiditis (HTn = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients. Results: There was a non significant trend for higher prevalence of GADA positivity in GD vs HT (7.2% vs 2% p = 0.06), but the GADA titers were higher in HT. We also did not find a significant difference in IA2 prevalence (0.7% vs 0.0%) between these two groups or compared to the control group. In the subsequent analysis, low FPIR was found in 10% of these patients but without statistical difference for OGTT between pancreatic antibody-positive and -negative patients. Conclusion: A trend for greater prevalence of GADA was observed for GD patients than for HT or control. However, the titers of these autoantibodies were higher in HT patients, but there was no significant relation to insulin secretion and glucose tolerance at that moment and stage of autoimmune diseases.Univ Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Div Endocrinol, Dept Med, Sao Paulo, SP, BrazilWeb of ScienceCNPq, BrazilCNPq: 133045/2001-3Sbem-Soc Brasil Endocrinologia & Metabologia2020-06-26T16:30:21Z2020-06-26T16:30:21Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion361-366application/pdfhttp://dx.doi.org/10.1590/2359-3997000000280Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017.10.1590/2359-3997000000280S2359-39972017000400361.pdf2359-3997S2359-39972017000400361https://repositorio.unifesp.br/handle/11600/53496WOS:000416003200010engArchives Of Endocrinology MetabolismRio De Janeiro, Rjinfo:eu-repo/semantics/openAccessSallorenzo, Carolina [UNIFESP]Silva, Regina [UNIFESP]Kasamatsu, Teresa [UNIFESP]Dib, Sergio [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T03:41:29Zoai:repositorio.unifesp.br/:11600/53496Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T03:41:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
title |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
spellingShingle |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance Sallorenzo, Carolina [UNIFESP] Autoimmune thyroid disease pancreatic autoantibodies glucose tolerance beta-cell function |
title_short |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
title_full |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
title_fullStr |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
title_full_unstemmed |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
title_sort |
Prevalence of pancreatic autoantibodies in non-diabetic patients with autoimmune thyroid disease and its relation to insulin secretion and glucose tolerance |
author |
Sallorenzo, Carolina [UNIFESP] |
author_facet |
Sallorenzo, Carolina [UNIFESP] Silva, Regina [UNIFESP] Kasamatsu, Teresa [UNIFESP] Dib, Sergio [UNIFESP] |
author_role |
author |
author2 |
Silva, Regina [UNIFESP] Kasamatsu, Teresa [UNIFESP] Dib, Sergio [UNIFESP] |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Sallorenzo, Carolina [UNIFESP] Silva, Regina [UNIFESP] Kasamatsu, Teresa [UNIFESP] Dib, Sergio [UNIFESP] |
dc.subject.por.fl_str_mv |
Autoimmune thyroid disease pancreatic autoantibodies glucose tolerance beta-cell function |
topic |
Autoimmune thyroid disease pancreatic autoantibodies glucose tolerance beta-cell function |
description |
Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2020-06-26T16:30:21Z 2020-06-26T16:30:21Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/2359-3997000000280 Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017. 10.1590/2359-3997000000280 S2359-39972017000400361.pdf 2359-3997 S2359-39972017000400361 https://repositorio.unifesp.br/handle/11600/53496 WOS:000416003200010 |
url |
http://dx.doi.org/10.1590/2359-3997000000280 https://repositorio.unifesp.br/handle/11600/53496 |
identifier_str_mv |
Archives Of Endocrinology Metabolism. Rio De Janeiro, Rj, v. 61, n. 4, p. 361-366, 2017. 10.1590/2359-3997000000280 S2359-39972017000400361.pdf 2359-3997 S2359-39972017000400361 WOS:000416003200010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives Of Endocrinology Metabolism |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
361-366 application/pdf |
dc.coverage.none.fl_str_mv |
Rio De Janeiro, Rj |
dc.publisher.none.fl_str_mv |
Sbem-Soc Brasil Endocrinologia & Metabologia |
publisher.none.fl_str_mv |
Sbem-Soc Brasil Endocrinologia & Metabologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268420987813888 |