Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases

Detalhes bibliográficos
Autor(a) principal: Silva, Avelar Alves de
Data de Publicação: 2015
Outros Autores: Pacheco-Silva, Alvaro [UNIFESP], Sesso, Ricardo de Castro Cintra [UNIFESP], Esmeraldo, Ronaldo de Matos, Oliveira, Claudia Maria Costa de, Fernandes, Paula Frassinetti Castelo Branco Camurca, Oliveira, Rodrigo Alves de, Silva, Leila Silveira Veira de, Carvalho, Valencio Pereira de, Costa, Carlos Henrique Nery, Andrade, Jesusmar Ximenes, Silva, Diana Marisa Barros da, Chaves, Roosevelt Valente
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1186/s12879-015-0852-9
http://repositorio.unifesp.br/handle/11600/38772
Resumo: Background: Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). in renal transplant recipients, visceral leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system, as well as poor outcomes for patients with transplanted kidneys. This study describes the largest series of cases of visceral leishmaniasis in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population.Methods: A retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with visceral leishmaniasis in the post-transplantation period.Results: in this study, visceral leishmaniasis was more frequent in men (80%). the mean age of presentation was 40 +/- 10.5 years. the majority of patients worked in urban areas (66.7%), cohabitated with domestic animals (90%), and were from low-income households. in 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. Patients were treated with liposomal amphotericin, resulting in a high degree of disease remission (80%).Conclusions: This study describes the largest series of visceral leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population.
id UFSP_a8e55ef57d535d8b34c7a1dbf5cda8b1
oai_identifier_str oai:repositorio.unifesp.br/:11600/38772
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty casesVisceral leishmaniasisRenal transplant recipientsInfection after transplantBackground: Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). in renal transplant recipients, visceral leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system, as well as poor outcomes for patients with transplanted kidneys. This study describes the largest series of cases of visceral leishmaniasis in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population.Methods: A retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with visceral leishmaniasis in the post-transplantation period.Results: in this study, visceral leishmaniasis was more frequent in men (80%). the mean age of presentation was 40 +/- 10.5 years. the majority of patients worked in urban areas (66.7%), cohabitated with domestic animals (90%), and were from low-income households. in 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. Patients were treated with liposomal amphotericin, resulting in a high degree of disease remission (80%).Conclusions: This study describes the largest series of visceral leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population.Univ Fed Piaui, Gen Clin Dept, Teresina, Piaui, BrazilHosp Alianca Casamater, Renal Transplant Unit, Teresina, Piaui, BrazilUniversidade Federal de São Paulo, Discipline Nephrol, São Paulo, BrazilHosp Israelita Albert Einstein, Renal Transplant Unit, São Paulo, BrazilGen Hosp Fortaleza, Renal Transplant Unit, Fortaleza, Ceara, BrazilUniv Fed Ceara, Cantidio Walter Univ Hosp, Renal Transplant Unit, Fortaleza, Ceara, BrazilUniv Crato, Sch Med, Renal Transplant Serv, Div Nephrol,Dr Joaquim Bezerra Unit, Crato, Ceara, BrazilUniv Fed Piaui, Infect Dis Hosp Dr Natan Portela, Teresina, Piaui, BrazilUniv Fed Piaui, Dept Accounting & Adm, Teresina, Piaui, BrazilUniversidade Federal de São Paulo, Discipline Nephrol, São Paulo, BrazilWeb of ScienceKidney Transplant Units of the Federal University of São PauloFederal University of CearaGeneral Hospital of FortalezaFederal University of PiauiBiomed Central LtdUniv Fed PiauiHosp Alianca CasamaterUniversidade Federal de São Paulo (UNIFESP)Hosp Israelita Albert EinsteinGen Hosp FortalezaUniv Fed CearaUniv CratoSilva, Avelar Alves dePacheco-Silva, Alvaro [UNIFESP]Sesso, Ricardo de Castro Cintra [UNIFESP]Esmeraldo, Ronaldo de MatosOliveira, Claudia Maria Costa deFernandes, Paula Frassinetti Castelo Branco CamurcaOliveira, Rodrigo Alves deSilva, Leila Silveira Veira deCarvalho, Valencio Pereira deCosta, Carlos Henrique NeryAndrade, Jesusmar XimenesSilva, Diana Marisa Barros daChaves, Roosevelt Valente2016-01-24T14:40:05Z2016-01-24T14:40:05Z2015-02-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10application/pdfhttp://dx.doi.org/10.1186/s12879-015-0852-9Bmc Infectious Diseases. London: Biomed Central Ltd, v. 15, 10 p., 2015.10.1186/s12879-015-0852-9WOS000351912400001.pdf1471-2334http://repositorio.unifesp.br/handle/11600/38772WOS:000351912400001engBmc Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-07T15:52:28Zoai:repositorio.unifesp.br/:11600/38772Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-10-07T15:52:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
title Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
spellingShingle Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
Silva, Avelar Alves de
Visceral leishmaniasis
Renal transplant recipients
Infection after transplant
title_short Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
title_full Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
title_fullStr Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
title_full_unstemmed Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
title_sort Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases
author Silva, Avelar Alves de
author_facet Silva, Avelar Alves de
Pacheco-Silva, Alvaro [UNIFESP]
Sesso, Ricardo de Castro Cintra [UNIFESP]
Esmeraldo, Ronaldo de Matos
Oliveira, Claudia Maria Costa de
Fernandes, Paula Frassinetti Castelo Branco Camurca
Oliveira, Rodrigo Alves de
Silva, Leila Silveira Veira de
Carvalho, Valencio Pereira de
Costa, Carlos Henrique Nery
Andrade, Jesusmar Ximenes
Silva, Diana Marisa Barros da
Chaves, Roosevelt Valente
author_role author
author2 Pacheco-Silva, Alvaro [UNIFESP]
Sesso, Ricardo de Castro Cintra [UNIFESP]
Esmeraldo, Ronaldo de Matos
Oliveira, Claudia Maria Costa de
Fernandes, Paula Frassinetti Castelo Branco Camurca
Oliveira, Rodrigo Alves de
Silva, Leila Silveira Veira de
Carvalho, Valencio Pereira de
Costa, Carlos Henrique Nery
Andrade, Jesusmar Ximenes
Silva, Diana Marisa Barros da
Chaves, Roosevelt Valente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Fed Piaui
Hosp Alianca Casamater
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Gen Hosp Fortaleza
Univ Fed Ceara
Univ Crato
dc.contributor.author.fl_str_mv Silva, Avelar Alves de
Pacheco-Silva, Alvaro [UNIFESP]
Sesso, Ricardo de Castro Cintra [UNIFESP]
Esmeraldo, Ronaldo de Matos
Oliveira, Claudia Maria Costa de
Fernandes, Paula Frassinetti Castelo Branco Camurca
Oliveira, Rodrigo Alves de
Silva, Leila Silveira Veira de
Carvalho, Valencio Pereira de
Costa, Carlos Henrique Nery
Andrade, Jesusmar Ximenes
Silva, Diana Marisa Barros da
Chaves, Roosevelt Valente
dc.subject.por.fl_str_mv Visceral leishmaniasis
Renal transplant recipients
Infection after transplant
topic Visceral leishmaniasis
Renal transplant recipients
Infection after transplant
description Background: Visceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). in renal transplant recipients, visceral leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system, as well as poor outcomes for patients with transplanted kidneys. This study describes the largest series of cases of visceral leishmaniasis in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population.Methods: A retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with visceral leishmaniasis in the post-transplantation period.Results: in this study, visceral leishmaniasis was more frequent in men (80%). the mean age of presentation was 40 +/- 10.5 years. the majority of patients worked in urban areas (66.7%), cohabitated with domestic animals (90%), and were from low-income households. in 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. Patients were treated with liposomal amphotericin, resulting in a high degree of disease remission (80%).Conclusions: This study describes the largest series of visceral leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population.
publishDate 2015
dc.date.none.fl_str_mv 2015-02-25
2016-01-24T14:40:05Z
2016-01-24T14:40:05Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12879-015-0852-9
Bmc Infectious Diseases. London: Biomed Central Ltd, v. 15, 10 p., 2015.
10.1186/s12879-015-0852-9
WOS000351912400001.pdf
1471-2334
http://repositorio.unifesp.br/handle/11600/38772
WOS:000351912400001
url http://dx.doi.org/10.1186/s12879-015-0852-9
http://repositorio.unifesp.br/handle/11600/38772
identifier_str_mv Bmc Infectious Diseases. London: Biomed Central Ltd, v. 15, 10 p., 2015.
10.1186/s12879-015-0852-9
WOS000351912400001.pdf
1471-2334
WOS:000351912400001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bmc Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268446037245952