Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.4314/tjpr.v12i6.14 http://repositorio.unifesp.br/handle/11600/37024 |
Resumo: | Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines. |
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Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in MiceZingiber officinaleGingerRoscoeEssential oilNephrotoxicityCisplatinPurpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines.Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04039002 São Paulo, BrazilUniv Estadual Maringa, Dept Chem, Maringa, Parana, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04039002 São Paulo, BrazilWeb of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Pharmacotherapy GroupUniversidade Estadual de Maringá (UEM)Universidade Federal de São Paulo (UNIFESP)Damiao, Marcio Jose [UNIFESP]Giannocco, Gisele [UNIFESP]Grespan, RenataSilva, Expedito LeiteDuarte, Janaina S. [UNIFESP]Maciel, Rui Monteiro de Barros [UNIFESP]Yamada, Alcileia NunesBersani-Amado, Ciomar AparecidaCuman, Roberto Kenji Nakamura2016-01-24T14:34:46Z2016-01-24T14:34:46Z2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion959-965http://dx.doi.org/10.4314/tjpr.v12i6.14Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013.10.4314/tjpr.v12i6.141596-5996http://repositorio.unifesp.br/handle/11600/37024WOS:000332072500014engTropical Journal of Pharmaceutical Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-18T10:14:09Zoai:repositorio.unifesp.br/:11600/37024Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-18T10:14:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
title |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
spellingShingle |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice Damiao, Marcio Jose [UNIFESP] Zingiber officinale Ginger Roscoe Essential oil Nephrotoxicity Cisplatin |
title_short |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
title_full |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
title_fullStr |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
title_full_unstemmed |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
title_sort |
Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice |
author |
Damiao, Marcio Jose [UNIFESP] |
author_facet |
Damiao, Marcio Jose [UNIFESP] Giannocco, Gisele [UNIFESP] Grespan, Renata Silva, Expedito Leite Duarte, Janaina S. [UNIFESP] Maciel, Rui Monteiro de Barros [UNIFESP] Yamada, Alcileia Nunes Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
author_role |
author |
author2 |
Giannocco, Gisele [UNIFESP] Grespan, Renata Silva, Expedito Leite Duarte, Janaina S. [UNIFESP] Maciel, Rui Monteiro de Barros [UNIFESP] Yamada, Alcileia Nunes Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Maringá (UEM) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Damiao, Marcio Jose [UNIFESP] Giannocco, Gisele [UNIFESP] Grespan, Renata Silva, Expedito Leite Duarte, Janaina S. [UNIFESP] Maciel, Rui Monteiro de Barros [UNIFESP] Yamada, Alcileia Nunes Bersani-Amado, Ciomar Aparecida Cuman, Roberto Kenji Nakamura |
dc.subject.por.fl_str_mv |
Zingiber officinale Ginger Roscoe Essential oil Nephrotoxicity Cisplatin |
topic |
Zingiber officinale Ginger Roscoe Essential oil Nephrotoxicity Cisplatin |
description |
Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 2016-01-24T14:34:46Z 2016-01-24T14:34:46Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4314/tjpr.v12i6.14 Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013. 10.4314/tjpr.v12i6.14 1596-5996 http://repositorio.unifesp.br/handle/11600/37024 WOS:000332072500014 |
url |
http://dx.doi.org/10.4314/tjpr.v12i6.14 http://repositorio.unifesp.br/handle/11600/37024 |
identifier_str_mv |
Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013. 10.4314/tjpr.v12i6.14 1596-5996 WOS:000332072500014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Tropical Journal of Pharmaceutical Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
959-965 |
dc.publisher.none.fl_str_mv |
Pharmacotherapy Group |
publisher.none.fl_str_mv |
Pharmacotherapy Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268268089704448 |