Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice

Detalhes bibliográficos
Autor(a) principal: Damiao, Marcio Jose [UNIFESP]
Data de Publicação: 2013
Outros Autores: Giannocco, Gisele [UNIFESP], Grespan, Renata, Silva, Expedito Leite, Duarte, Janaina S. [UNIFESP], Maciel, Rui Monteiro de Barros [UNIFESP], Yamada, Alcileia Nunes, Bersani-Amado, Ciomar Aparecida, Cuman, Roberto Kenji Nakamura
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.4314/tjpr.v12i6.14
http://repositorio.unifesp.br/handle/11600/37024
Resumo: Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines.
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spelling Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in MiceZingiber officinaleGingerRoscoeEssential oilNephrotoxicityCisplatinPurpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines.Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04039002 São Paulo, BrazilUniv Estadual Maringa, Dept Chem, Maringa, Parana, BrazilUniversidade Federal de São Paulo, Dept Endocrinol, BR-04039002 São Paulo, BrazilWeb of ScienceCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Pharmacotherapy GroupUniversidade Estadual de Maringá (UEM)Universidade Federal de São Paulo (UNIFESP)Damiao, Marcio Jose [UNIFESP]Giannocco, Gisele [UNIFESP]Grespan, RenataSilva, Expedito LeiteDuarte, Janaina S. [UNIFESP]Maciel, Rui Monteiro de Barros [UNIFESP]Yamada, Alcileia NunesBersani-Amado, Ciomar AparecidaCuman, Roberto Kenji Nakamura2016-01-24T14:34:46Z2016-01-24T14:34:46Z2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion959-965http://dx.doi.org/10.4314/tjpr.v12i6.14Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013.10.4314/tjpr.v12i6.141596-5996http://repositorio.unifesp.br/handle/11600/37024WOS:000332072500014engTropical Journal of Pharmaceutical Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-18T10:14:09Zoai:repositorio.unifesp.br/:11600/37024Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-18T10:14:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
title Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
spellingShingle Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
Damiao, Marcio Jose [UNIFESP]
Zingiber officinale
Ginger
Roscoe
Essential oil
Nephrotoxicity
Cisplatin
title_short Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
title_full Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
title_fullStr Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
title_full_unstemmed Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
title_sort Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice
author Damiao, Marcio Jose [UNIFESP]
author_facet Damiao, Marcio Jose [UNIFESP]
Giannocco, Gisele [UNIFESP]
Grespan, Renata
Silva, Expedito Leite
Duarte, Janaina S. [UNIFESP]
Maciel, Rui Monteiro de Barros [UNIFESP]
Yamada, Alcileia Nunes
Bersani-Amado, Ciomar Aparecida
Cuman, Roberto Kenji Nakamura
author_role author
author2 Giannocco, Gisele [UNIFESP]
Grespan, Renata
Silva, Expedito Leite
Duarte, Janaina S. [UNIFESP]
Maciel, Rui Monteiro de Barros [UNIFESP]
Yamada, Alcileia Nunes
Bersani-Amado, Ciomar Aparecida
Cuman, Roberto Kenji Nakamura
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Maringá (UEM)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Damiao, Marcio Jose [UNIFESP]
Giannocco, Gisele [UNIFESP]
Grespan, Renata
Silva, Expedito Leite
Duarte, Janaina S. [UNIFESP]
Maciel, Rui Monteiro de Barros [UNIFESP]
Yamada, Alcileia Nunes
Bersani-Amado, Ciomar Aparecida
Cuman, Roberto Kenji Nakamura
dc.subject.por.fl_str_mv Zingiber officinale
Ginger
Roscoe
Essential oil
Nephrotoxicity
Cisplatin
topic Zingiber officinale
Ginger
Roscoe
Essential oil
Nephrotoxicity
Cisplatin
description Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines.
publishDate 2013
dc.date.none.fl_str_mv 2013-12-01
2016-01-24T14:34:46Z
2016-01-24T14:34:46Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4314/tjpr.v12i6.14
Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013.
10.4314/tjpr.v12i6.14
1596-5996
http://repositorio.unifesp.br/handle/11600/37024
WOS:000332072500014
url http://dx.doi.org/10.4314/tjpr.v12i6.14
http://repositorio.unifesp.br/handle/11600/37024
identifier_str_mv Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013.
10.4314/tjpr.v12i6.14
1596-5996
WOS:000332072500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tropical Journal of Pharmaceutical Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 959-965
dc.publisher.none.fl_str_mv Pharmacotherapy Group
publisher.none.fl_str_mv Pharmacotherapy Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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