Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1038/sj.bjp.0702177 http://repositorio.unifesp.br/handle/11600/25970 |
Resumo: | 1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide. |
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Repositório Institucional da UNIFESP |
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Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive ratsalpha-2 adrenoceptorsmesenteric arteriesendotheliumspontaneously hypertensive ratspotassium channelsmembrane potential1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide.Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilEscola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilWeb of ScienceStockton PressUniversidade Federal de São Paulo (UNIFESP)Feres, Teresa [UNIFESP]Borges, Antonio Carlos Romao [UNIFESP]Silva, Eneida de Gusmão [UNIFESP]Paiva, Antonio Cechelli de Mattos [UNIFESP]Paiva, Therezinha Bandiera [UNIFESP]2016-01-24T12:30:41Z2016-01-24T12:30:41Z1998-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1144-1149http://dx.doi.org/10.1038/sj.bjp.0702177British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998.10.1038/sj.bjp.07021770007-1188http://repositorio.unifesp.br/handle/11600/25970WOS:000077085800005engBritish Journal of Pharmacologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2018-09-18T11:35:27Zoai:repositorio.unifesp.br/:11600/25970Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652018-09-18T11:35:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
title |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
spellingShingle |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats Feres, Teresa [UNIFESP] alpha-2 adrenoceptors mesenteric arteries endothelium spontaneously hypertensive rats potassium channels membrane potential |
title_short |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
title_full |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
title_fullStr |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
title_full_unstemmed |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
title_sort |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats |
author |
Feres, Teresa [UNIFESP] |
author_facet |
Feres, Teresa [UNIFESP] Borges, Antonio Carlos Romao [UNIFESP] Silva, Eneida de Gusmão [UNIFESP] Paiva, Antonio Cechelli de Mattos [UNIFESP] Paiva, Therezinha Bandiera [UNIFESP] |
author_role |
author |
author2 |
Borges, Antonio Carlos Romao [UNIFESP] Silva, Eneida de Gusmão [UNIFESP] Paiva, Antonio Cechelli de Mattos [UNIFESP] Paiva, Therezinha Bandiera [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Feres, Teresa [UNIFESP] Borges, Antonio Carlos Romao [UNIFESP] Silva, Eneida de Gusmão [UNIFESP] Paiva, Antonio Cechelli de Mattos [UNIFESP] Paiva, Therezinha Bandiera [UNIFESP] |
dc.subject.por.fl_str_mv |
alpha-2 adrenoceptors mesenteric arteries endothelium spontaneously hypertensive rats potassium channels membrane potential |
topic |
alpha-2 adrenoceptors mesenteric arteries endothelium spontaneously hypertensive rats potassium channels membrane potential |
description |
1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-11-01 2016-01-24T12:30:41Z 2016-01-24T12:30:41Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/sj.bjp.0702177 British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998. 10.1038/sj.bjp.0702177 0007-1188 http://repositorio.unifesp.br/handle/11600/25970 WOS:000077085800005 |
url |
http://dx.doi.org/10.1038/sj.bjp.0702177 http://repositorio.unifesp.br/handle/11600/25970 |
identifier_str_mv |
British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998. 10.1038/sj.bjp.0702177 0007-1188 WOS:000077085800005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
British Journal of Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1144-1149 |
dc.publisher.none.fl_str_mv |
Stockton Press |
publisher.none.fl_str_mv |
Stockton Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268416643563520 |