Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats

Detalhes bibliográficos
Autor(a) principal: Feres, Teresa [UNIFESP]
Data de Publicação: 1998
Outros Autores: Borges, Antonio Carlos Romao [UNIFESP], Silva, Eneida de Gusmão [UNIFESP], Paiva, Antonio Cechelli de Mattos [UNIFESP], Paiva, Therezinha Bandiera [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1038/sj.bjp.0702177
http://repositorio.unifesp.br/handle/11600/25970
Resumo: 1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide.
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spelling Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive ratsalpha-2 adrenoceptorsmesenteric arteriesendotheliumspontaneously hypertensive ratspotassium channelsmembrane potential1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide.Escola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilEscola Paulista Med, Dept Biophys, BR-04023062 São Paulo, BrazilWeb of ScienceStockton PressUniversidade Federal de São Paulo (UNIFESP)Feres, Teresa [UNIFESP]Borges, Antonio Carlos Romao [UNIFESP]Silva, Eneida de Gusmão [UNIFESP]Paiva, Antonio Cechelli de Mattos [UNIFESP]Paiva, Therezinha Bandiera [UNIFESP]2016-01-24T12:30:41Z2016-01-24T12:30:41Z1998-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1144-1149http://dx.doi.org/10.1038/sj.bjp.0702177British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998.10.1038/sj.bjp.07021770007-1188http://repositorio.unifesp.br/handle/11600/25970WOS:000077085800005engBritish Journal of Pharmacologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2018-09-18T11:35:27Zoai:repositorio.unifesp.br/:11600/25970Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652018-09-18T11:35:27Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
title Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
spellingShingle Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
Feres, Teresa [UNIFESP]
alpha-2 adrenoceptors
mesenteric arteries
endothelium
spontaneously hypertensive rats
potassium channels
membrane potential
title_short Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
title_full Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
title_fullStr Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
title_full_unstemmed Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
title_sort Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats
author Feres, Teresa [UNIFESP]
author_facet Feres, Teresa [UNIFESP]
Borges, Antonio Carlos Romao [UNIFESP]
Silva, Eneida de Gusmão [UNIFESP]
Paiva, Antonio Cechelli de Mattos [UNIFESP]
Paiva, Therezinha Bandiera [UNIFESP]
author_role author
author2 Borges, Antonio Carlos Romao [UNIFESP]
Silva, Eneida de Gusmão [UNIFESP]
Paiva, Antonio Cechelli de Mattos [UNIFESP]
Paiva, Therezinha Bandiera [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Feres, Teresa [UNIFESP]
Borges, Antonio Carlos Romao [UNIFESP]
Silva, Eneida de Gusmão [UNIFESP]
Paiva, Antonio Cechelli de Mattos [UNIFESP]
Paiva, Therezinha Bandiera [UNIFESP]
dc.subject.por.fl_str_mv alpha-2 adrenoceptors
mesenteric arteries
endothelium
spontaneously hypertensive rats
potassium channels
membrane potential
topic alpha-2 adrenoceptors
mesenteric arteries
endothelium
spontaneously hypertensive rats
potassium channels
membrane potential
description 1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by N-omega-nitro-L-arginine.4 It is concluded that the activity of potassium channels coupled to alpha(2)-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha(2)-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide.
publishDate 1998
dc.date.none.fl_str_mv 1998-11-01
2016-01-24T12:30:41Z
2016-01-24T12:30:41Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/sj.bjp.0702177
British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998.
10.1038/sj.bjp.0702177
0007-1188
http://repositorio.unifesp.br/handle/11600/25970
WOS:000077085800005
url http://dx.doi.org/10.1038/sj.bjp.0702177
http://repositorio.unifesp.br/handle/11600/25970
identifier_str_mv British Journal of Pharmacology. Basingstoke: Stockton Press, v. 125, n. 6, p. 1144-1149, 1998.
10.1038/sj.bjp.0702177
0007-1188
WOS:000077085800005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv British Journal of Pharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1144-1149
dc.publisher.none.fl_str_mv Stockton Press
publisher.none.fl_str_mv Stockton Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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