Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.14814/phy2.12888 https://repositorio.unifesp.br/handle/11600/57449 |
Resumo: | The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR. |
id |
UFSP_ada4af9a43781f6556db92b3e3376034 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/57449 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspringBlood pressurefemale offspringrenal functionsleep restrictionThe influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR.Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Rua Botucatu 862,5th Floor, BR-04023900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, BrazilUniv Sao Paulo, Basic Res Lab, LIM12, Nephrol,Fac Med, Sao Paulo, SP, BrazilCtr Univ Sao Camilo, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Rua Botucatu 862,5th Floor, BR-04023900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, BrazilWeb of ScienceFAPESPFAPESP: 2013/23622-7Wiley2020-08-14T13:43:56Z2020-08-14T13:43:56Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.14814/phy2.12888Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016.10.14814/phy2.12888WOS000383442800005.pdf2051-817Xhttps://repositorio.unifesp.br/handle/11600/57449WOS:000383442800005engPhysiological ReportsHobokeninfo:eu-repo/semantics/openAccessArgeri, Rogerio [UNIFESP]Nishi, Erika E. [UNIFESP]Volpini, Rildo A. [UNIFESP]Palma, Beatriz D.Tufik, Sergio [UNIFESP]Gomes, Guiomar N. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T04:07:21Zoai:repositorio.unifesp.br/:11600/57449Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T04:07:21Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
title |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
spellingShingle |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring Argeri, Rogerio [UNIFESP] Blood pressure female offspring renal function sleep restriction |
title_short |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
title_full |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
title_fullStr |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
title_full_unstemmed |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
title_sort |
Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring |
author |
Argeri, Rogerio [UNIFESP] |
author_facet |
Argeri, Rogerio [UNIFESP] Nishi, Erika E. [UNIFESP] Volpini, Rildo A. [UNIFESP] Palma, Beatriz D. Tufik, Sergio [UNIFESP] Gomes, Guiomar N. [UNIFESP] |
author_role |
author |
author2 |
Nishi, Erika E. [UNIFESP] Volpini, Rildo A. [UNIFESP] Palma, Beatriz D. Tufik, Sergio [UNIFESP] Gomes, Guiomar N. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Argeri, Rogerio [UNIFESP] Nishi, Erika E. [UNIFESP] Volpini, Rildo A. [UNIFESP] Palma, Beatriz D. Tufik, Sergio [UNIFESP] Gomes, Guiomar N. [UNIFESP] |
dc.subject.por.fl_str_mv |
Blood pressure female offspring renal function sleep restriction |
topic |
Blood pressure female offspring renal function sleep restriction |
description |
The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-08-14T13:43:56Z 2020-08-14T13:43:56Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.14814/phy2.12888 Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016. 10.14814/phy2.12888 WOS000383442800005.pdf 2051-817X https://repositorio.unifesp.br/handle/11600/57449 WOS:000383442800005 |
url |
http://dx.doi.org/10.14814/phy2.12888 https://repositorio.unifesp.br/handle/11600/57449 |
identifier_str_mv |
Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016. 10.14814/phy2.12888 WOS000383442800005.pdf 2051-817X WOS:000383442800005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- application/pdf |
dc.coverage.none.fl_str_mv |
Hoboken |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1824718244755275776 |