Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring

Detalhes bibliográficos
Autor(a) principal: Argeri, Rogerio [UNIFESP]
Data de Publicação: 2016
Outros Autores: Nishi, Erika E. [UNIFESP], Volpini, Rildo A. [UNIFESP], Palma, Beatriz D., Tufik, Sergio [UNIFESP], Gomes, Guiomar N. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.14814/phy2.12888
https://repositorio.unifesp.br/handle/11600/57449
Resumo: The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR.
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spelling Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspringBlood pressurefemale offspringrenal functionsleep restrictionThe influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR.Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Rua Botucatu 862,5th Floor, BR-04023900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, BrazilUniv Sao Paulo, Basic Res Lab, LIM12, Nephrol,Fac Med, Sao Paulo, SP, BrazilCtr Univ Sao Camilo, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Rua Botucatu 862,5th Floor, BR-04023900 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, BrazilWeb of ScienceFAPESPFAPESP: 2013/23622-7Wiley2020-08-14T13:43:56Z2020-08-14T13:43:56Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.14814/phy2.12888Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016.10.14814/phy2.12888WOS000383442800005.pdf2051-817Xhttps://repositorio.unifesp.br/handle/11600/57449WOS:000383442800005engPhysiological ReportsHobokeninfo:eu-repo/semantics/openAccessArgeri, Rogerio [UNIFESP]Nishi, Erika E. [UNIFESP]Volpini, Rildo A. [UNIFESP]Palma, Beatriz D.Tufik, Sergio [UNIFESP]Gomes, Guiomar N. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T04:07:21Zoai:repositorio.unifesp.br/:11600/57449Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T04:07:21Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
title Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
spellingShingle Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
Argeri, Rogerio [UNIFESP]
Blood pressure
female offspring
renal function
sleep restriction
title_short Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
title_full Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
title_fullStr Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
title_full_unstemmed Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
title_sort Sleep restriction during pregnancy and its effects on blood pressure and renal function among female offspring
author Argeri, Rogerio [UNIFESP]
author_facet Argeri, Rogerio [UNIFESP]
Nishi, Erika E. [UNIFESP]
Volpini, Rildo A. [UNIFESP]
Palma, Beatriz D.
Tufik, Sergio [UNIFESP]
Gomes, Guiomar N. [UNIFESP]
author_role author
author2 Nishi, Erika E. [UNIFESP]
Volpini, Rildo A. [UNIFESP]
Palma, Beatriz D.
Tufik, Sergio [UNIFESP]
Gomes, Guiomar N. [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Argeri, Rogerio [UNIFESP]
Nishi, Erika E. [UNIFESP]
Volpini, Rildo A. [UNIFESP]
Palma, Beatriz D.
Tufik, Sergio [UNIFESP]
Gomes, Guiomar N. [UNIFESP]
dc.subject.por.fl_str_mv Blood pressure
female offspring
renal function
sleep restriction
topic Blood pressure
female offspring
renal function
sleep restriction
description The influence of sleep restriction (SR) during pregnancy on blood pressure and renal function among female adult offspring was investigated. Pregnant Wistar rats were distributed into control and SR groups. The SR was performed between the 14th and 20th days of pregnancy (multiple platforms method for 20h/day). At 2months of age, half of the offspring from both groups were subjected to an ovariectomy (ovx), and the other half underwent sham surgery. The groups were as follows: control sham (C-sham), control ovx (C-ovx), SR sham (SRsham), and SR ovx (SRovx). Renal function markers andsystolic blood pressure (BPi, indirect method) were evaluated at 4, 6, and 8months. Subsequently, the rats were euthanized, kidneys were removed, and processed for morphological analyses of glomerular area (GA), number of glomeruli per mm(3) (NG), and kidney mass (KM). Increased BPi was observed in the C-ovx, SRsham, and SRovx groups compared to C-sham at all ages. Increased plasma creatinine concentration and decreased creatinine clearance were observed in the SRsham and SRovx groups compared to the C-sham and C-ovx groups. The SRovx group showed higher BPi and reduced creatinine clearance compared to all other groups. The SRovx group showed reduced values of GA and KM, as well as increased NG, macrophage infiltration, collagen deposit, and ACE1 expression at the renal cortex. Therefore, SR during pregnancy might be an additional risk factor for developing renal dysfunction and increasing BP in female adult offspring. The absence of female hormones exacerbates the changes caused by SR.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-08-14T13:43:56Z
2020-08-14T13:43:56Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.14814/phy2.12888
Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016.
10.14814/phy2.12888
WOS000383442800005.pdf
2051-817X
https://repositorio.unifesp.br/handle/11600/57449
WOS:000383442800005
url http://dx.doi.org/10.14814/phy2.12888
https://repositorio.unifesp.br/handle/11600/57449
identifier_str_mv Physiological Reports. Hoboken, v. 4, n. 16, p. -, 2016.
10.14814/phy2.12888
WOS000383442800005.pdf
2051-817X
WOS:000383442800005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Physiological Reports
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv Hoboken
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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