Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis

Detalhes bibliográficos
Autor(a) principal: Cristelli, M. P. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Cofan, F., Rico, N., Trullas, J. C., Manzardo, C., Aguero, F., Bedini, J. L., Moreno, A., Oppenheimer, F., Miro, J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000zdnq
DOI: 10.1186/s12882-017-0470-4
Texto Completo: http://dx.doi.org/10.1186/s12882-017-0470-4
https://repositorio.unifesp.br/handle/11600/55105
Resumo: Background: Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods: Cross-sectional, single center study including adult patients with HIV-infection. Results: Four thousand five hundred three patients with HIV-infection (864 women
id UFSP_ae94447a41552b8fdab6ace75e580ad7
oai_identifier_str oai:repositorio.unifesp.br/:11600/55105
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysisHIV-infectionChronic kidney diseaseGlomerular filtration rate estimatesBackground: Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods: Cross-sectional, single center study including adult patients with HIV-infection. Results: Four thousand five hundred three patients with HIV-infection (864 women19%) were examined. Median age was 45 years (IQR 37-52), and median baseline creatinine was 0.93 mg/dL (IQR 0.82-1.05). A similar distribution of absolute measures of eGFR was found using both formulas (p = 0.548). Baseline median eGFR was 95.2 and 90.4 mL/min/ 1.73 m(2) for CKD-EPI and MDRD equations (p < 0.001), respectively. Of the 4503 measurements, 4109 (91.2%) agreed, with a kappa index of 0.803. MDRD classified 7.3% of patients as '' mild reduced GFR '' who were classified as '' normal function '' with CKD-EPI. Using CKD-EPI, it was possible to identify '' normal function '' (>90 mL/min/1.73 m(2)) in 73% patients and '' mild reduced GFR '' (60-89 mL/min/1.73 m(2)) in 24.3% of the patients, formerly classified as >60 mL/min/1.73 m(2) with MDRD. Conclusions: There was good correlation between CKD-EPI and MDRD. Estimating renal function using CKD-EPI equation allowed better staging of renal function and should be considered the method of choice. CKD-EPI identified a significant proportion of patients (24%) with mild reduced GFR (60-89 mL/min/1.73 m(2)).Univ Fed Sao Paulo, Kidney Transplant Div, Hosp Rim, Sao Paulo, BrazilUniv Barcelona, Hosp Clin IDIBAPS, Nephrol & Renal Transplantat Serv, Barcelona, SpainHosp Clin Barcelona, Biomed Diag Ctr, Core Lab, Barcelona, SpainHosp Olot, Internal Med Serv, Girona, SpainUniv Girona, Dept Med Sci, Girona, SpainUniv Barcelona, Hosp Clin IDIBAPS, Infect Dis Serv, Barcelona, SpainUniv Fed Sao Paulo, Kidney Transplant Div, Hosp Rim, Sao Paulo, BrazilWeb of ScienceRed de SidaInstituto de Salud Carlos III, Madrid, SpainEuropean Regional Development Fund (ERDF)Red de Sida: RD12/0017/0001Instituto de Salud Carlos III, Madrid, Spain: INT15/00168Biomed Central Ltd2020-07-17T14:02:58Z2020-07-17T14:02:58Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1186/s12882-017-0470-4Bmc Nephrology. London, v. 18, p. -, 2017.10.1186/s12882-017-0470-4WOS000397680500002.pdf1471-2369https://repositorio.unifesp.br/handle/11600/55105WOS:000397680500002ark:/48912/001300000zdnqengBmc NephrologyLondoninfo:eu-repo/semantics/openAccessCristelli, M. P. [UNIFESP]Cofan, F.Rico, N.Trullas, J. C.Manzardo, C.Aguero, F.Bedini, J. L.Moreno, A.Oppenheimer, F.Miro, J. M.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T02:11:29Zoai:repositorio.unifesp.br/:11600/55105Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:45:18.370858Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
title Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
spellingShingle Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
Cristelli, M. P. [UNIFESP]
HIV-infection
Chronic kidney disease
Glomerular filtration rate estimates
Cristelli, M. P. [UNIFESP]
HIV-infection
Chronic kidney disease
Glomerular filtration rate estimates
title_short Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
title_full Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
title_fullStr Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
title_full_unstemmed Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
title_sort Estimation of renal function by CKD-EPI versus MDRD in a cohort of HIV-infected patients: a cross-sectional analysis
author Cristelli, M. P. [UNIFESP]
author_facet Cristelli, M. P. [UNIFESP]
Cristelli, M. P. [UNIFESP]
Cofan, F.
Rico, N.
Trullas, J. C.
Manzardo, C.
Aguero, F.
Bedini, J. L.
Moreno, A.
Oppenheimer, F.
Miro, J. M.
Cofan, F.
Rico, N.
Trullas, J. C.
Manzardo, C.
Aguero, F.
Bedini, J. L.
Moreno, A.
Oppenheimer, F.
Miro, J. M.
author_role author
author2 Cofan, F.
Rico, N.
Trullas, J. C.
Manzardo, C.
Aguero, F.
Bedini, J. L.
Moreno, A.
Oppenheimer, F.
Miro, J. M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cristelli, M. P. [UNIFESP]
Cofan, F.
Rico, N.
Trullas, J. C.
Manzardo, C.
Aguero, F.
Bedini, J. L.
Moreno, A.
Oppenheimer, F.
Miro, J. M.
dc.subject.por.fl_str_mv HIV-infection
Chronic kidney disease
Glomerular filtration rate estimates
topic HIV-infection
Chronic kidney disease
Glomerular filtration rate estimates
description Background: Accurately determining renal function is essential for clinical management of HIV patients. Classically, it has been evaluated by estimating glomerular filtration rate (eGFR) with the MDRD-equation, but today there is evidence that the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has greater diagnostic accuracy. To date, however, little information exists on patients with HIV-infection. This study aimed to evaluate eGFR by CKD-EPI vs. MDRD equations and to stratify renal function according to KDIGO guidelines. Methods: Cross-sectional, single center study including adult patients with HIV-infection. Results: Four thousand five hundred three patients with HIV-infection (864 women
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-17T14:02:58Z
2020-07-17T14:02:58Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12882-017-0470-4
Bmc Nephrology. London, v. 18, p. -, 2017.
10.1186/s12882-017-0470-4
WOS000397680500002.pdf
1471-2369
https://repositorio.unifesp.br/handle/11600/55105
WOS:000397680500002
dc.identifier.dark.fl_str_mv ark:/48912/001300000zdnq
url http://dx.doi.org/10.1186/s12882-017-0470-4
https://repositorio.unifesp.br/handle/11600/55105
identifier_str_mv Bmc Nephrology. London, v. 18, p. -, 2017.
10.1186/s12882-017-0470-4
WOS000397680500002.pdf
1471-2369
WOS:000397680500002
ark:/48912/001300000zdnq
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bmc Nephrology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822219236942020608
dc.identifier.doi.none.fl_str_mv 10.1186/s12882-017-0470-4

Registros relacionados