Hemorrhoids: an experimental model in monkeys

Detalhes bibliográficos
Autor(a) principal: Plapler, Helio [UNIFESP]
Data de Publicação: 2006
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502006000500014
http://repositorio.unifesp.br/handle/11600/3308
Resumo: PURPOSE: Hemorrhoids are a matter of concern due to a painful outcome. We describe a simple, easy and reliable experimental model to produce hemorrhoids in monkeys. METHODS: 14 monkeys (Cebus apella) were used. After general anesthesia, hemorrhoids were induced by ligation of the inferior hemorrhoidal vein, which is very alike to humans. The vein was located through a perianal incision, dissected and ligated with a 3-0 vicryl. The skin was sutured with a 4-0 catgut thread. Animals were kept in appropriate cages and evaluated daily. RESULTS: Nine days later there were hemorrhoidal piles in the anus in fifty percent (50%) of the animals. Outcome was unremarkable. There was no bleeding and all animals showed no signs of pain or suffering. CONCLUSION: This is an affordable and reliable experimental model to induce hemorrhoids for experimental studies.
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spelling Hemorrhoids: an experimental model in monkeysHemorróidas: modelo experimental em macacosHemorrhoidsColorectal SurgeryCebusHemorróidasCirurgia ColorretalCebusPURPOSE: Hemorrhoids are a matter of concern due to a painful outcome. We describe a simple, easy and reliable experimental model to produce hemorrhoids in monkeys. METHODS: 14 monkeys (Cebus apella) were used. After general anesthesia, hemorrhoids were induced by ligation of the inferior hemorrhoidal vein, which is very alike to humans. The vein was located through a perianal incision, dissected and ligated with a 3-0 vicryl. The skin was sutured with a 4-0 catgut thread. Animals were kept in appropriate cages and evaluated daily. RESULTS: Nine days later there were hemorrhoidal piles in the anus in fifty percent (50%) of the animals. Outcome was unremarkable. There was no bleeding and all animals showed no signs of pain or suffering. CONCLUSION: This is an affordable and reliable experimental model to induce hemorrhoids for experimental studies.OBJETIVO: Hemorróidas são objeto de preocupação devido à evolução dolorosa no pós-operatório. Descrevemos aqui um modelo experimental simples e confiável de indução de hemorróidas em macacos. MÉTODOS: 14 macacos-prego (Cebus apella) foram empregados. Após anestesia geral induziu-se a formação de hemorróidas pela ligadura da veia hemorroidária inferior, que é muito parecida com a de humanos. A veia foi localizada através de uma incisão perianal, dissecada e ligada com fio de vicryl 3-0. A pele foi suturada com fio de categute 4-0. Os animais foram mantidos em jaulas apropriadas e avaliados diariamente. RESULTADOS: Nove dias após o procedimento havia mamilos hemorroidários em cinqüenta por cento (50%) dos animais. Não houve intercorrências no pós-operatório. Não houve sangramento ou sinais de dor ou de sofrimento. CONCLUSÃO: Este é um modelo viável e confiável para induzir hemorróidas para estudos experimentais.UNIFESPUniversidade Federal de São Paulo, EPM, São Paulo, BrazilSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Federal de São Paulo (UNIFESP)Plapler, Helio [UNIFESP]2015-06-14T13:36:29Z2015-06-14T13:36:29Z2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion354-356application/pdfhttp://dx.doi.org/10.1590/S0102-86502006000500014Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 21, n. 5, p. 354-356, 2006.10.1590/S0102-86502006000500014S0102-86502006000500014.pdf0102-8650S0102-86502006000500014http://repositorio.unifesp.br/handle/11600/3308engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T01:33:03Zoai:repositorio.unifesp.br/:11600/3308Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T01:33:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Hemorrhoids: an experimental model in monkeys
Hemorróidas: modelo experimental em macacos
title Hemorrhoids: an experimental model in monkeys
spellingShingle Hemorrhoids: an experimental model in monkeys
Plapler, Helio [UNIFESP]
Hemorrhoids
Colorectal Surgery
Cebus
Hemorróidas
Cirurgia Colorretal
Cebus
title_short Hemorrhoids: an experimental model in monkeys
title_full Hemorrhoids: an experimental model in monkeys
title_fullStr Hemorrhoids: an experimental model in monkeys
title_full_unstemmed Hemorrhoids: an experimental model in monkeys
title_sort Hemorrhoids: an experimental model in monkeys
author Plapler, Helio [UNIFESP]
author_facet Plapler, Helio [UNIFESP]
author_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Plapler, Helio [UNIFESP]
dc.subject.por.fl_str_mv Hemorrhoids
Colorectal Surgery
Cebus
Hemorróidas
Cirurgia Colorretal
Cebus
topic Hemorrhoids
Colorectal Surgery
Cebus
Hemorróidas
Cirurgia Colorretal
Cebus
description PURPOSE: Hemorrhoids are a matter of concern due to a painful outcome. We describe a simple, easy and reliable experimental model to produce hemorrhoids in monkeys. METHODS: 14 monkeys (Cebus apella) were used. After general anesthesia, hemorrhoids were induced by ligation of the inferior hemorrhoidal vein, which is very alike to humans. The vein was located through a perianal incision, dissected and ligated with a 3-0 vicryl. The skin was sutured with a 4-0 catgut thread. Animals were kept in appropriate cages and evaluated daily. RESULTS: Nine days later there were hemorrhoidal piles in the anus in fifty percent (50%) of the animals. Outcome was unremarkable. There was no bleeding and all animals showed no signs of pain or suffering. CONCLUSION: This is an affordable and reliable experimental model to induce hemorrhoids for experimental studies.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
2015-06-14T13:36:29Z
2015-06-14T13:36:29Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502006000500014
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 21, n. 5, p. 354-356, 2006.
10.1590/S0102-86502006000500014
S0102-86502006000500014.pdf
0102-8650
S0102-86502006000500014
http://repositorio.unifesp.br/handle/11600/3308
url http://dx.doi.org/10.1590/S0102-86502006000500014
http://repositorio.unifesp.br/handle/11600/3308
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 21, n. 5, p. 354-356, 2006.
10.1590/S0102-86502006000500014
S0102-86502006000500014.pdf
0102-8650
S0102-86502006000500014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 354-356
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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