Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
Autor(a) principal: | |
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Data de Publicação: | 1993 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1002/ptr.2650070605 http://repositorio.unifesp.br/handle/11600/45112 |
Resumo: | The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process. |
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Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodentsSCOPARIA-DULCIS LSCROPHULARIACEAEMEDICINAL PLANTGLUTINOLANALGESICANTIINFLAMMATORY ACTIONSRATS AND MICEThe analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.ESCOLA PAULISTA MED,DEPT PHARMACOL,NAT PROD SECT,04044-020 RUA TRES MAIO 100,SAO PAULO,SP,BRAZILUNIV FED MARANHAO,DEPT PHYSIOL SCI,MARANHAO,GO,BRAZILUNIV FED MARANHAO,DEPT CHEM,MARANHAO,GO,BRAZILESCOLA PAULISTA MED,DEPT PHARMACOL,NAT PROD SECT,04044-020 RUA TRES MAIO 100,SAO PAULO,SP,BRAZILWeb of ScienceWiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)UNIV FED MARANHAOFreire, Sonia Maria de FariasEmim, José Artur da Silva [UNIFESP]Lapa, Antonio José [UNIFESP]Souccar, Caden [UNIFESP]Torres, Luce Maria Brandão2018-06-18T11:27:08Z2018-06-18T11:27:08Z1993-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion408-414http://dx.doi.org/10.1002/ptr.2650070605Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993.10.1002/ptr.26500706050951-418Xhttp://repositorio.unifesp.br/handle/11600/45112WOS:A1993ML69000004engPhytotherapy Researchinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:33Zoai:repositorio.unifesp.br/:11600/45112Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
title |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
spellingShingle |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents Freire, Sonia Maria de Farias SCOPARIA-DULCIS L SCROPHULARIACEAE MEDICINAL PLANT GLUTINOL ANALGESIC ANTIINFLAMMATORY ACTIONS RATS AND MICE |
title_short |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
title_full |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
title_fullStr |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
title_full_unstemmed |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
title_sort |
Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents |
author |
Freire, Sonia Maria de Farias |
author_facet |
Freire, Sonia Maria de Farias Emim, José Artur da Silva [UNIFESP] Lapa, Antonio José [UNIFESP] Souccar, Caden [UNIFESP] Torres, Luce Maria Brandão |
author_role |
author |
author2 |
Emim, José Artur da Silva [UNIFESP] Lapa, Antonio José [UNIFESP] Souccar, Caden [UNIFESP] Torres, Luce Maria Brandão |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) UNIV FED MARANHAO |
dc.contributor.author.fl_str_mv |
Freire, Sonia Maria de Farias Emim, José Artur da Silva [UNIFESP] Lapa, Antonio José [UNIFESP] Souccar, Caden [UNIFESP] Torres, Luce Maria Brandão |
dc.subject.por.fl_str_mv |
SCOPARIA-DULCIS L SCROPHULARIACEAE MEDICINAL PLANT GLUTINOL ANALGESIC ANTIINFLAMMATORY ACTIONS RATS AND MICE |
topic |
SCOPARIA-DULCIS L SCROPHULARIACEAE MEDICINAL PLANT GLUTINOL ANALGESIC ANTIINFLAMMATORY ACTIONS RATS AND MICE |
description |
The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process. |
publishDate |
1993 |
dc.date.none.fl_str_mv |
1993-11-01 2018-06-18T11:27:08Z 2018-06-18T11:27:08Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/ptr.2650070605 Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993. 10.1002/ptr.2650070605 0951-418X http://repositorio.unifesp.br/handle/11600/45112 WOS:A1993ML69000004 |
url |
http://dx.doi.org/10.1002/ptr.2650070605 http://repositorio.unifesp.br/handle/11600/45112 |
identifier_str_mv |
Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993. 10.1002/ptr.2650070605 0951-418X WOS:A1993ML69000004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Phytotherapy Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
dc.format.none.fl_str_mv |
408-414 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268370881609728 |