Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents

Detalhes bibliográficos
Autor(a) principal: Freire, Sonia Maria de Farias
Data de Publicação: 1993
Outros Autores: Emim, José Artur da Silva [UNIFESP], Lapa, Antonio José [UNIFESP], Souccar, Caden [UNIFESP], Torres, Luce Maria Brandão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1002/ptr.2650070605
http://repositorio.unifesp.br/handle/11600/45112
Resumo: The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.
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spelling Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodentsSCOPARIA-DULCIS LSCROPHULARIACEAEMEDICINAL PLANTGLUTINOLANALGESICANTIINFLAMMATORY ACTIONSRATS AND MICEThe analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.ESCOLA PAULISTA MED,DEPT PHARMACOL,NAT PROD SECT,04044-020 RUA TRES MAIO 100,SAO PAULO,SP,BRAZILUNIV FED MARANHAO,DEPT PHYSIOL SCI,MARANHAO,GO,BRAZILUNIV FED MARANHAO,DEPT CHEM,MARANHAO,GO,BRAZILESCOLA PAULISTA MED,DEPT PHARMACOL,NAT PROD SECT,04044-020 RUA TRES MAIO 100,SAO PAULO,SP,BRAZILWeb of ScienceWiley-BlackwellUniversidade Federal de São Paulo (UNIFESP)UNIV FED MARANHAOFreire, Sonia Maria de FariasEmim, José Artur da Silva [UNIFESP]Lapa, Antonio José [UNIFESP]Souccar, Caden [UNIFESP]Torres, Luce Maria Brandão2018-06-18T11:27:08Z2018-06-18T11:27:08Z1993-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion408-414http://dx.doi.org/10.1002/ptr.2650070605Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993.10.1002/ptr.26500706050951-418Xhttp://repositorio.unifesp.br/handle/11600/45112WOS:A1993ML69000004engPhytotherapy Researchinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:52:33Zoai:repositorio.unifesp.br/:11600/45112Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:52:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
title Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
spellingShingle Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
Freire, Sonia Maria de Farias
SCOPARIA-DULCIS L
SCROPHULARIACEAE
MEDICINAL PLANT
GLUTINOL
ANALGESIC
ANTIINFLAMMATORY ACTIONS
RATS AND MICE
title_short Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
title_full Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
title_fullStr Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
title_full_unstemmed Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
title_sort Analgesic and antiinflammatory properties of Scoparia dulcis L. Extracts and glutinol in rodents
author Freire, Sonia Maria de Farias
author_facet Freire, Sonia Maria de Farias
Emim, José Artur da Silva [UNIFESP]
Lapa, Antonio José [UNIFESP]
Souccar, Caden [UNIFESP]
Torres, Luce Maria Brandão
author_role author
author2 Emim, José Artur da Silva [UNIFESP]
Lapa, Antonio José [UNIFESP]
Souccar, Caden [UNIFESP]
Torres, Luce Maria Brandão
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
UNIV FED MARANHAO
dc.contributor.author.fl_str_mv Freire, Sonia Maria de Farias
Emim, José Artur da Silva [UNIFESP]
Lapa, Antonio José [UNIFESP]
Souccar, Caden [UNIFESP]
Torres, Luce Maria Brandão
dc.subject.por.fl_str_mv SCOPARIA-DULCIS L
SCROPHULARIACEAE
MEDICINAL PLANT
GLUTINOL
ANALGESIC
ANTIINFLAMMATORY ACTIONS
RATS AND MICE
topic SCOPARIA-DULCIS L
SCROPHULARIACEAE
MEDICINAL PLANT
GLUTINOL
ANALGESIC
ANTIINFLAMMATORY ACTIONS
RATS AND MICE
description The analgesic, antiinflammatory and antipyretic activities of the water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were tested in mice and rats. Both extracts (0.5 and 1 g/kg) p.o., prolonged the sleeping time induced by pentobarbital in mice, EE being more active than WE. Injections of EE (0.5-2 mg/kg i.v.) to anaesthetized rats induced a dose-related hypertension inhibited by alpha-blocker drugs; the hypertension was not obtained after oral treatment. EE (0.25-1 g/kg p.o.) but not WE, reduced writhings induced by acetic acid in mice. Glutinol (30 mg/kg p.o.), a major triterpene obtained from EE, produced the same effect. The tail flick response of mice was not influenced by either extract. EE (0.5 and 1 g/kg) and glutinol (30 mg/kg) p.o., reduced the paw oedema and pleurisy induced by carrageenin in rats, but only EE (1 g/kg) reduced the paw oedema induced by dextran or histamine. No effect of EE was detected on chronic inflammation induced by cotton pellets and in yeast-induced hyperthermia in rats. The results indicate that the extract of S. dulcis is endowed with analgesic effects probably related to the antiinflammatory activity of the plant. Those effects are related mainly to the presence of glutinol and flavonoids, which exert their action on the early phase of the acute inflammatory process.
publishDate 1993
dc.date.none.fl_str_mv 1993-11-01
2018-06-18T11:27:08Z
2018-06-18T11:27:08Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1002/ptr.2650070605
Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993.
10.1002/ptr.2650070605
0951-418X
http://repositorio.unifesp.br/handle/11600/45112
WOS:A1993ML69000004
url http://dx.doi.org/10.1002/ptr.2650070605
http://repositorio.unifesp.br/handle/11600/45112
identifier_str_mv Phytotherapy Research. W Sussex: John Wiley & Sons Ltd, v. 7, n. 6, p. 408-414, 1993.
10.1002/ptr.2650070605
0951-418X
WOS:A1993ML69000004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Phytotherapy Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://olabout.wiley.com/WileyCDA/Section/id-406071.html
eu_rights_str_mv openAccess
rights_invalid_str_mv http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.format.none.fl_str_mv 408-414
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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