Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis

Detalhes bibliográficos
Autor(a) principal: Longo, Priscila Larcher
Data de Publicação: 2014
Outros Autores: Artese, Hilana Paula Carillo, Rabelo, Mariana de Sousa, Kawamoto, Dione, Foz, Adriana Moura, Romito, Giuseppe Alexandre, Dib, Sergio Atala [UNIFESP], Mayer, Marcia Pinto Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/1678-775720130540
http://repositorio.unifesp.br/handle/11600/8328
Resumo: Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.
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spelling Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitisDiabetes mellitusPeriodontitisCytokinesInflammationDiabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.University of São Paulo Institute of Biomedical Sciences Department of MicrobiologyUniversity of São Paulo School of Dentistry Department of StomatologyFederal University of São Paulo School of Medicine Department of EndocrinologyUNIFESP, EPM, Department of EndocrinologySciELOFaculdade De Odontologia De Bauru - USPUniversity of São Paulo Institute of Biomedical Sciences Department of MicrobiologyUniversity of São Paulo School of Dentistry Department of StomatologyUniversidade Federal de São Paulo (UNIFESP)Longo, Priscila LarcherArtese, Hilana Paula CarilloRabelo, Mariana de SousaKawamoto, DioneFoz, Adriana MouraRomito, Giuseppe AlexandreDib, Sergio Atala [UNIFESP]Mayer, Marcia Pinto Alves2015-06-14T13:47:02Z2015-06-14T13:47:02Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion103-108application/pdfhttp://dx.doi.org/10.1590/1678-775720130540Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014.10.1590/1678-775720130540S1678-77572014000200103.pdf1678-7757S1678-77572014000200103http://repositorio.unifesp.br/handle/11600/8328engJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T02:49:26Zoai:repositorio.unifesp.br/:11600/8328Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T02:49:26Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
title Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
spellingShingle Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
Longo, Priscila Larcher
Diabetes mellitus
Periodontitis
Cytokines
Inflammation
title_short Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
title_full Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
title_fullStr Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
title_full_unstemmed Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
title_sort Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
author Longo, Priscila Larcher
author_facet Longo, Priscila Larcher
Artese, Hilana Paula Carillo
Rabelo, Mariana de Sousa
Kawamoto, Dione
Foz, Adriana Moura
Romito, Giuseppe Alexandre
Dib, Sergio Atala [UNIFESP]
Mayer, Marcia Pinto Alves
author_role author
author2 Artese, Hilana Paula Carillo
Rabelo, Mariana de Sousa
Kawamoto, Dione
Foz, Adriana Moura
Romito, Giuseppe Alexandre
Dib, Sergio Atala [UNIFESP]
Mayer, Marcia Pinto Alves
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv University of São Paulo Institute of Biomedical Sciences Department of Microbiology
University of São Paulo School of Dentistry Department of Stomatology
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Longo, Priscila Larcher
Artese, Hilana Paula Carillo
Rabelo, Mariana de Sousa
Kawamoto, Dione
Foz, Adriana Moura
Romito, Giuseppe Alexandre
Dib, Sergio Atala [UNIFESP]
Mayer, Marcia Pinto Alves
dc.subject.por.fl_str_mv Diabetes mellitus
Periodontitis
Cytokines
Inflammation
topic Diabetes mellitus
Periodontitis
Cytokines
Inflammation
description Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.
publishDate 2014
dc.date.none.fl_str_mv 2014-04-01
2015-06-14T13:47:02Z
2015-06-14T13:47:02Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-775720130540
Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014.
10.1590/1678-775720130540
S1678-77572014000200103.pdf
1678-7757
S1678-77572014000200103
http://repositorio.unifesp.br/handle/11600/8328
url http://dx.doi.org/10.1590/1678-775720130540
http://repositorio.unifesp.br/handle/11600/8328
identifier_str_mv Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014.
10.1590/1678-775720130540
S1678-77572014000200103.pdf
1678-7757
S1678-77572014000200103
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Applied Oral Science
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 103-108
application/pdf
dc.publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
publisher.none.fl_str_mv Faculdade De Odontologia De Bauru - USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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