Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-775720130540 http://repositorio.unifesp.br/handle/11600/8328 |
Resumo: | Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups. |
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Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitisDiabetes mellitusPeriodontitisCytokinesInflammationDiabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.University of São Paulo Institute of Biomedical Sciences Department of MicrobiologyUniversity of São Paulo School of Dentistry Department of StomatologyFederal University of São Paulo School of Medicine Department of EndocrinologyUNIFESP, EPM, Department of EndocrinologySciELOFaculdade De Odontologia De Bauru - USPUniversity of São Paulo Institute of Biomedical Sciences Department of MicrobiologyUniversity of São Paulo School of Dentistry Department of StomatologyUniversidade Federal de São Paulo (UNIFESP)Longo, Priscila LarcherArtese, Hilana Paula CarilloRabelo, Mariana de SousaKawamoto, DioneFoz, Adriana MouraRomito, Giuseppe AlexandreDib, Sergio Atala [UNIFESP]Mayer, Marcia Pinto Alves2015-06-14T13:47:02Z2015-06-14T13:47:02Z2014-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion103-108application/pdfhttp://dx.doi.org/10.1590/1678-775720130540Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014.10.1590/1678-775720130540S1678-77572014000200103.pdf1678-7757S1678-77572014000200103http://repositorio.unifesp.br/handle/11600/8328engJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T02:49:26Zoai:repositorio.unifesp.br/:11600/8328Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T02:49:26Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
title |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
spellingShingle |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis Longo, Priscila Larcher Diabetes mellitus Periodontitis Cytokines Inflammation |
title_short |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
title_full |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
title_fullStr |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
title_full_unstemmed |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
title_sort |
Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis |
author |
Longo, Priscila Larcher |
author_facet |
Longo, Priscila Larcher Artese, Hilana Paula Carillo Rabelo, Mariana de Sousa Kawamoto, Dione Foz, Adriana Moura Romito, Giuseppe Alexandre Dib, Sergio Atala [UNIFESP] Mayer, Marcia Pinto Alves |
author_role |
author |
author2 |
Artese, Hilana Paula Carillo Rabelo, Mariana de Sousa Kawamoto, Dione Foz, Adriana Moura Romito, Giuseppe Alexandre Dib, Sergio Atala [UNIFESP] Mayer, Marcia Pinto Alves |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
University of São Paulo Institute of Biomedical Sciences Department of Microbiology University of São Paulo School of Dentistry Department of Stomatology Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Longo, Priscila Larcher Artese, Hilana Paula Carillo Rabelo, Mariana de Sousa Kawamoto, Dione Foz, Adriana Moura Romito, Giuseppe Alexandre Dib, Sergio Atala [UNIFESP] Mayer, Marcia Pinto Alves |
dc.subject.por.fl_str_mv |
Diabetes mellitus Periodontitis Cytokines Inflammation |
topic |
Diabetes mellitus Periodontitis Cytokines Inflammation |
description |
Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04-01 2015-06-14T13:47:02Z 2015-06-14T13:47:02Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-775720130540 Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014. 10.1590/1678-775720130540 S1678-77572014000200103.pdf 1678-7757 S1678-77572014000200103 http://repositorio.unifesp.br/handle/11600/8328 |
url |
http://dx.doi.org/10.1590/1678-775720130540 http://repositorio.unifesp.br/handle/11600/8328 |
identifier_str_mv |
Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014. 10.1590/1678-775720130540 S1678-77572014000200103.pdf 1678-7757 S1678-77572014000200103 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Oral Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
103-108 application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268415988203520 |