Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

• Autor(a) principal: Ferreira Filho, Celso [UNIFESP]
• Data de Publicação: 2010
• Outros Autores: Abreu, Luiz Carlos de, Valenti, Vitor Engrácia [UNIFESP], Ferreira, Marcelo, Meneghini, Adriano, Silveira, José Alexandre, Perez Riera, Andrés Ricardo [UNIFESP], Colombari, Eduardo [UNIFESP], Murad, Neif, Santos-Silva, Paulo Roberto, Silva, Lovian José Henrique Pereira da, Vanderlei, Luiz Carlos Marques, Carvalho, Tatiana Dias de [UNIFESP], Ferreira, Celso [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S1807-59322010000700012; http://repositorio.unifesp.br/handle/11600/5488
• topic: Hypertrophy; Cardiomyopathy; Hypertrophic; Left ventricle hypertension; Cardiology

OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.