O estadiamento TNM do carcinoma de células renais deve ser modificado novamente ?

• Autor(a) principal: Dall'Oglio, Marcos Francisco [UNIFESP]
• Data de Publicação: 2003
• Outros Autores: Srougi, Miguel [UNIFESP], Nesrallah, Luciano [UNIFESP], Leite, Kátia Ramos Moreira [UNIFESP], Hering, Flávio [UNIFESP], Bomfim, Alexandre de Campos [UNIFESP], Sanudo, Adriana [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0104-42302003000100039; http://repositorio.unifesp.br/handle/11600/1597
• topic: Carcinoma renal cell; Neoplasm staging; Neoplasms; Neoplasm recurrence; TNM classification; Carcinoma de células renais; Estadiamento; Neoplasias; Neoplasia recorrente

OBJECTIVE: The behavior of the renal cells carcinoma stage PT1 is not completely clarified. We studied the presence of factors after prognostics and tumoral size in the recurrence of survival of the sporadic kidney carcinoma after surgical treatment. METHODS: 120 patients followed after nephrectomy had been revised retrospectively 93 PT1, 9 PT2, 11 PT3, 7 PT4, It was analyzed survival and recurrence of the disease inside of three groups of tumors: Group 1: < 4cm, group 2: 4-7cm and group 3: > 7cm, and the prognostics factors above-mentioned evaluated were nuclear degree, microvascular invasion, presence of committed ganglia and sarcomatous degeneration. RESULTS: The frequency of adverse prognostics factors increase as the tumor size increase. In the group 1, we had only four tumors of high degree and only one shown microvascular invasion that does not committed ganglia or sarcomatous degeneration. In group 2 there was 16 tumors of high degree, 4 sarcomatoses, two with positive microvascular invasion and two with positive ganglia. In group 3, was found 18 tumors of high degree, 15 with microvascular invasion and 7 with positive ganglia and 5 sarcomatoses. There was statistical significance in the specific cancer survival (p=0.002) and free of illness (p=0.0002) between the three groups. CONCLUSION: The evolution of tumors PT1 is distinct for lesser tumors of 4 cm and 4-7 cm fitting the subdivision of these two groups in T1a and T1b.