Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1707 http://dx.doi.org/10.1590/S0100-879X2003000400011 |
Resumo: | Hormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation. |
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Uint, LucianaGebara, Otávio Celso ElufPinto, Lígia B.Wajngarten, MaurícioBoschcov, Paulo [UNIFESP]Luz, Protásio Lemos daGidlund, MagnusUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:30:00Z2015-06-14T13:30:00Z2003-04-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 4, p. 491-494, 2003.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1707http://dx.doi.org/10.1590/S0100-879X2003000400011S0100-879X2003000400011.pdfS0100-879X200300040001110.1590/S0100-879X2003000400011WOS:000182664000011Hormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation.Universidade de São Paulo Faculdade de Medicina Instituto do CoraçãoUniversidade Federal de São Paulo (UNIFESP) Departamento de BiofísicaUniversidade de São Paulo Instituto de Ciências Biomédicas IV Departamento de Imunologia and Instituto de Medicina Tropical da Universidade de São PauloUNIFESP, Depto. de BiofísicaSciELO491-494engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchHormone replacement therapyPostmenopauseOxidized LDLHeat shock proteinImmune responseAntibodiesHormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoproteininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2003000400011.pdfapplication/pdf464230${dspace.ui.url}/bitstream/11600/1707/1/S0100-879X2003000400011.pdfb7e91c4fd3dbcc5070f6683f9ed043a1MD51open accessTEXTS0100-879X2003000400011.pdf.txtS0100-879X2003000400011.pdf.txtExtracted texttext/plain14868${dspace.ui.url}/bitstream/11600/1707/2/S0100-879X2003000400011.pdf.txt5b8052811eae631e41d801afa4466712MD52open access11600/17072021-09-29 11:23:43.211open accessoai:repositorio.unifesp.br:11600/1707Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T14:23:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
title |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
spellingShingle |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein Uint, Luciana Hormone replacement therapy Postmenopause Oxidized LDL Heat shock protein Immune response Antibodies |
title_short |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
title_full |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
title_fullStr |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
title_full_unstemmed |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
title_sort |
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein |
author |
Uint, Luciana |
author_facet |
Uint, Luciana Gebara, Otávio Celso Eluf Pinto, Lígia B. Wajngarten, Maurício Boschcov, Paulo [UNIFESP] Luz, Protásio Lemos da Gidlund, Magnus |
author_role |
author |
author2 |
Gebara, Otávio Celso Eluf Pinto, Lígia B. Wajngarten, Maurício Boschcov, Paulo [UNIFESP] Luz, Protásio Lemos da Gidlund, Magnus |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Uint, Luciana Gebara, Otávio Celso Eluf Pinto, Lígia B. Wajngarten, Maurício Boschcov, Paulo [UNIFESP] Luz, Protásio Lemos da Gidlund, Magnus |
dc.subject.eng.fl_str_mv |
Hormone replacement therapy Postmenopause Oxidized LDL Heat shock protein Immune response Antibodies |
topic |
Hormone replacement therapy Postmenopause Oxidized LDL Heat shock protein Immune response Antibodies |
description |
Hormone replacement therapy (HRT) reduces cardiovascular risks, although the initiation of therapy may be associated with transient adverse ischemic and thrombotic events. Antibodies against heat shock protein (Hsp) and oxidized low density lipoprotein (LDL) have been found in atherosclerotic lesions and plasma of patients with coronary artery disease and may play an important role in the pathogenesis of atherosclerosis. The aim of the present study was to assess the effects of HRT on the immune response by measuring plasma levels of antibodies against Hsp 65 and LDL with a low and high degree of copper-mediated oxidative modification of 20 postmenopausal women before and 90 days after receiving orally 0.625 mg equine conjugate estrogen plus 2.5 mg medroxyprogesterone acetate per day. HRT significantly increased antibodies against Hsp 65 (0.316 ± 0.03 vs 0.558 ± 0.11) and against LDL with a low degree of oxidative modification (0.100 ± 0.01 vs 0.217 ± 0.02) (P<0.05 and P<0.001, respectively, ANOVA). The hormone-mediated immune response may trigger an inflammatory response within the vessel wall and potentially increase plaque burden. Whether or not this immune response is temporary or sustained and deleterious requires further investigation. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003-04-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:30:00Z |
dc.date.available.fl_str_mv |
2015-06-14T13:30:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 4, p. 491-494, 2003. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1707 http://dx.doi.org/10.1590/S0100-879X2003000400011 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2003000400011.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2003000400011 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2003000400011 |
dc.identifier.wos.none.fl_str_mv |
WOS:000182664000011 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 4, p. 491-494, 2003. 0100-879X S0100-879X2003000400011.pdf S0100-879X2003000400011 10.1590/S0100-879X2003000400011 WOS:000182664000011 |
url |
http://repositorio.unifesp.br/handle/11600/1707 http://dx.doi.org/10.1590/S0100-879X2003000400011 |
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eng |
language |
eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
491-494 |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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