Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?

Detalhes bibliográficos
Autor(a) principal: Peres, Fernanda Fiel [UNIFESP]
Data de Publicação: 2018
Outros Autores: Lima, Alvaro C., Hallak, Jaime E. C., Crippa, José Alexandre de Souza [UNIFESP], Silva, Regina Helena da [UNIFESP], Abilio, Vanessa Costhek [UNIFESP]
Tipo de documento: Artigo (review)
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.3389/fphar.2018.00482
http://repositorio.unifesp.br/handle/11600/46042
Resumo: Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still mainly symptomatic, do not benefit all patients and induce severe side effects. Cannabidiol is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. Although the studies that investigate the effects of this compound on movement disorders are surprisingly few, cannabidiol emerges as a promising compound to treat and/or prevent them. Here, we review these clinical and pre-clinical studies and draw attention to the potential of cannabidiol in this field.
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spelling Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?cannabidiolmovement disordersParkinson's diseaseHuntington's diseasedystonic disorderscannabinoidsMovement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still mainly symptomatic, do not benefit all patients and induce severe side effects. Cannabidiol is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. Although the studies that investigate the effects of this compound on movement disorders are surprisingly few, cannabidiol emerges as a promising compound to treat and/or prevent them. Here, we review these clinical and pre-clinical studies and draw attention to the potential of cannabidiol in this field.Univ Fed Sao Paulo, Dept Pharmacol, Lab Behav Neurosci, Sao Paulo, BrazilNatl Inst Translat Med INCT TM, CNPq, FAPESP, CAPES, Ribeirao Preto, BrazilUniv Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, BrazilUniv Fed Sao Paulo, Dept Pharmacol, Lab Behav Neurosci, Sao Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (FAEPA, Brazil)Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil (NAPNA)National Institute for Translational Medicine (INCT-TM)National Institute for Translational Medicine (CNPq/FAPESP, Brazil)University Global Partnership Network (UGPN)-Global priorities in cannabinoid research excellenceFrontiers Media Sa2018-07-26T12:18:48Z2018-07-26T12:18:48Z2018info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.3389/fphar.2018.00482Frontiers In Pharmacology. Lausanne, v. 9, p. -, 2018.10.3389/fphar.2018.00482WOS000431876000001.pdf1663-9812http://repositorio.unifesp.br/handle/11600/46042WOS:000431876000001enginfo:eu-repo/semantics/openAccessPeres, Fernanda Fiel [UNIFESP]Lima, Alvaro C.Hallak, Jaime E. C.Crippa, José Alexandre de Souza [UNIFESP]Silva, Regina Helena da [UNIFESP]Abilio, Vanessa Costhek [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-03T05:05:28Zoai:repositorio.unifesp.br/:11600/46042Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-03T05:05:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
title Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
spellingShingle Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
Peres, Fernanda Fiel [UNIFESP]
cannabidiol
movement disorders
Parkinson's disease
Huntington's disease
dystonic disorders
cannabinoids
title_short Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
title_full Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
title_fullStr Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
title_full_unstemmed Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
title_sort Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
author Peres, Fernanda Fiel [UNIFESP]
author_facet Peres, Fernanda Fiel [UNIFESP]
Lima, Alvaro C.
Hallak, Jaime E. C.
Crippa, José Alexandre de Souza [UNIFESP]
Silva, Regina Helena da [UNIFESP]
Abilio, Vanessa Costhek [UNIFESP]
author_role author
author2 Lima, Alvaro C.
Hallak, Jaime E. C.
Crippa, José Alexandre de Souza [UNIFESP]
Silva, Regina Helena da [UNIFESP]
Abilio, Vanessa Costhek [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Peres, Fernanda Fiel [UNIFESP]
Lima, Alvaro C.
Hallak, Jaime E. C.
Crippa, José Alexandre de Souza [UNIFESP]
Silva, Regina Helena da [UNIFESP]
Abilio, Vanessa Costhek [UNIFESP]
dc.subject.por.fl_str_mv cannabidiol
movement disorders
Parkinson's disease
Huntington's disease
dystonic disorders
cannabinoids
topic cannabidiol
movement disorders
Parkinson's disease
Huntington's disease
dystonic disorders
cannabinoids
description Movement disorders such as Parkinson's disease and dyskinesia are highly debilitating conditions linked to oxidative stress and neurodegeneration. When available, the pharmacological therapies for these disorders are still mainly symptomatic, do not benefit all patients and induce severe side effects. Cannabidiol is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. Although the studies that investigate the effects of this compound on movement disorders are surprisingly few, cannabidiol emerges as a promising compound to treat and/or prevent them. Here, we review these clinical and pre-clinical studies and draw attention to the potential of cannabidiol in this field.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-26T12:18:48Z
2018-07-26T12:18:48Z
2018
dc.type.driver.fl_str_mv info:eu-repo/semantics/review
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format review
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3389/fphar.2018.00482
Frontiers In Pharmacology. Lausanne, v. 9, p. -, 2018.
10.3389/fphar.2018.00482
WOS000431876000001.pdf
1663-9812
http://repositorio.unifesp.br/handle/11600/46042
WOS:000431876000001
url http://dx.doi.org/10.3389/fphar.2018.00482
http://repositorio.unifesp.br/handle/11600/46042
identifier_str_mv Frontiers In Pharmacology. Lausanne, v. 9, p. -, 2018.
10.3389/fphar.2018.00482
WOS000431876000001.pdf
1663-9812
WOS:000431876000001
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268278514647040

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