Meningeoma de goteira olfatória: relação entre achados clínico-radiológicos e índice proliferativo (Mib-1)

• Autor(a) principal: Paiva Neto, Manoel Antonio de [UNIFESP]
• Data de Publicação: 2006
• Outros Autores: Tella Jr, Oswaldo Inácio de [UNIFESP], Herculano, Marco Antonio [UNIFESP], Stávale, João Norberto [UNIFESP], Bonatteli, Antonio Pádua Furquim [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-282X2006000100016; http://repositorio.unifesp.br/handle/11600/2961
• topic: meningioma; olfactory groove; edema; proliferative index; Mib-1; meningeoma; goteira olfatória; edema; índice proliferativo; Mib-1

OBJECTIVE: The aim of this study is to correlationate demografic, radiologic features and proliferative index defined by imunohistochemical expression of Mib-1 in olfactory groove meningiomas, and to observe possible predictive factors of recurrence of this tumor. METHOD: There were analysed demografic, clinical and radiological features of 15 patients with olfactory groove meningioma. Fifteen paraffin-embebed tumors were studied by imunohistochemical methods for the expression of proliferative index by the Mib-1. RESULTS: There was a statiscally positive correlation between tumoral and edema volumes. There was no correlation betweem Mib-1, tumoral volume, tumoral edema and frontal skull base abnormalities. Two cases with tumor recurrence had proliferative indices higher than the mean index. CONCLUSION: Larger tumors were more susceptible to develop peritumoral edema. The proliferative índex has no positive correlation with tumoral volume, edema volumes and skull base invasion, but probably it is associated with tumoral recurrence.