Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats

Detalhes bibliográficos
Autor(a) principal: Caous, Cristofer André [UNIFESP]
Data de Publicação: 2012
Outros Autores: Smith, Ricardo Luiz [UNIFESP], Freymüller-Haapalainen, Edna [UNIFESP], Lindsey, Charles Julian [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1679-45082012000200006
http://repositorio.unifesp.br/handle/11600/7113
Resumo: OBJECTIVE: Morphological study that searched to authenticate the presence of sinoaortic baroreceptor inputs within the dorsolateral medullary nucleus under electron microscopy analysis. METHODS: After a 5-day survival period, 9 baroreceptor-denervated rats deeply anaesthetized with equithesin were transcardially perfused and their brains were histologically processed. RESULTS: The neuronal cytoarchitecture of the paratrigeminal nucleus comprehends afferent projections from other nuclei that have a distributive character regarding visceral and nociceptive functions in the cardiovascular reflex integration response. CONCLUSION: The medial portion of the nucleus receives afferent projections of the rostral ventrolateral medulla, as shown by retrograde neurotracing studies. The present results show that the medial extent of the paratrigeminal nucleus contains degenerated axoplasmic cellular components in sinoaortic deafferented rats. The number of degenerated axonal fibers was also larger in this area of the nucleus.
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spelling Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented ratsEstudo ultraestrutural de degeneração transneuronal dos elementos axonais do núcleo paratrigeminal de ratos com desnervação sino-aórticaNerve degenerationTrigeminal nucleus, spinalBaroreflexDenervationMicroscopy, electronMedulla oblongataDegeneração neuralNúcleo espinal do trigêmeoBarorreflexoDesnervaçãoMicroscopia eletrônicaBulboOBJECTIVE: Morphological study that searched to authenticate the presence of sinoaortic baroreceptor inputs within the dorsolateral medullary nucleus under electron microscopy analysis. METHODS: After a 5-day survival period, 9 baroreceptor-denervated rats deeply anaesthetized with equithesin were transcardially perfused and their brains were histologically processed. RESULTS: The neuronal cytoarchitecture of the paratrigeminal nucleus comprehends afferent projections from other nuclei that have a distributive character regarding visceral and nociceptive functions in the cardiovascular reflex integration response. CONCLUSION: The medial portion of the nucleus receives afferent projections of the rostral ventrolateral medulla, as shown by retrograde neurotracing studies. The present results show that the medial extent of the paratrigeminal nucleus contains degenerated axoplasmic cellular components in sinoaortic deafferented rats. The number of degenerated axonal fibers was also larger in this area of the nucleus.OBJETIVO: Estudo morfológico que buscou verificar, por meio de microscopia eletrônica, a presença de aferências de receptores sino-aórticos em núcleo localizado na região dorso-lateral bulbar. MÉTODOS: Após 5 dias de sobrevida, 9 ratos com desnervação sino-aórtica anestesiados com equitesina foram submetidos à perfusão transcardíaca, e o encéfalo de cada um deles foi processado histologicamente. RESULTADOS: A citoarquitetura neuronal do núcleo paratrigeminal compreende projeções aferentes de outros núcleos que apresentam uma característica distributiva em relação às funções viscerais e nociceptivas na integração do reflexo cardiovascular. CONCLUSÃO: A porção medial do núcleo recebe projeções aferentes da região rostro-ventrolateral do troncoencefálico, confirmadas por meio de estudos com rastreadores neuronais. Os resultados indicam que a região medial do núcleo paratrigeminal contém o maior número de fibras axonais degeneradas.Hospital Israelita Albert Einstein Instituto do CérebroUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo (UNIFESP) Centro de Microscopia EletrônicaUNIFESP, Centro de Microscopia EletrônicaSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Israelita de Ensino e Pesquisa Albert EinsteinHospital Israelita Albert Einstein Instituto do CérebroUniversidade Federal de São Paulo (UNIFESP)Caous, Cristofer André [UNIFESP]Smith, Ricardo Luiz [UNIFESP]Freymüller-Haapalainen, Edna [UNIFESP]Lindsey, Charles Julian [UNIFESP]2015-06-14T13:44:43Z2015-06-14T13:44:43Z2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion145-150application/pdfhttp://dx.doi.org/10.1590/S1679-45082012000200006Einstein (São Paulo). Instituto Israelita de Ensino e Pesquisa Albert Einstein, v. 10, n. 2, p. 145-150, 2012.10.1590/S1679-45082012000200006S1679-45082012000200006.pdf1679-4508S1679-45082012000200006http://repositorio.unifesp.br/handle/11600/7113engEinstein (São Paulo)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T09:14:28Zoai:repositorio.unifesp.br/:11600/7113Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T09:14:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
Estudo ultraestrutural de degeneração transneuronal dos elementos axonais do núcleo paratrigeminal de ratos com desnervação sino-aórtica
title Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
spellingShingle Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
Caous, Cristofer André [UNIFESP]
Nerve degeneration
Trigeminal nucleus, spinal
Baroreflex
Denervation
Microscopy, electron
Medulla oblongata
Degeneração neural
Núcleo espinal do trigêmeo
Barorreflexo
Desnervação
Microscopia eletrônica
Bulbo
title_short Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
title_full Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
title_fullStr Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
title_full_unstemmed Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
title_sort Ultrastructural transneuronal degeneration study of axonal elements within the paratrigeminal nucleus in sinoaortic deafferented rats
author Caous, Cristofer André [UNIFESP]
author_facet Caous, Cristofer André [UNIFESP]
Smith, Ricardo Luiz [UNIFESP]
Freymüller-Haapalainen, Edna [UNIFESP]
Lindsey, Charles Julian [UNIFESP]
author_role author
author2 Smith, Ricardo Luiz [UNIFESP]
Freymüller-Haapalainen, Edna [UNIFESP]
Lindsey, Charles Julian [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Hospital Israelita Albert Einstein Instituto do Cérebro
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Caous, Cristofer André [UNIFESP]
Smith, Ricardo Luiz [UNIFESP]
Freymüller-Haapalainen, Edna [UNIFESP]
Lindsey, Charles Julian [UNIFESP]
dc.subject.por.fl_str_mv Nerve degeneration
Trigeminal nucleus, spinal
Baroreflex
Denervation
Microscopy, electron
Medulla oblongata
Degeneração neural
Núcleo espinal do trigêmeo
Barorreflexo
Desnervação
Microscopia eletrônica
Bulbo
topic Nerve degeneration
Trigeminal nucleus, spinal
Baroreflex
Denervation
Microscopy, electron
Medulla oblongata
Degeneração neural
Núcleo espinal do trigêmeo
Barorreflexo
Desnervação
Microscopia eletrônica
Bulbo
description OBJECTIVE: Morphological study that searched to authenticate the presence of sinoaortic baroreceptor inputs within the dorsolateral medullary nucleus under electron microscopy analysis. METHODS: After a 5-day survival period, 9 baroreceptor-denervated rats deeply anaesthetized with equithesin were transcardially perfused and their brains were histologically processed. RESULTS: The neuronal cytoarchitecture of the paratrigeminal nucleus comprehends afferent projections from other nuclei that have a distributive character regarding visceral and nociceptive functions in the cardiovascular reflex integration response. CONCLUSION: The medial portion of the nucleus receives afferent projections of the rostral ventrolateral medulla, as shown by retrograde neurotracing studies. The present results show that the medial extent of the paratrigeminal nucleus contains degenerated axoplasmic cellular components in sinoaortic deafferented rats. The number of degenerated axonal fibers was also larger in this area of the nucleus.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
2015-06-14T13:44:43Z
2015-06-14T13:44:43Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1679-45082012000200006
Einstein (São Paulo). Instituto Israelita de Ensino e Pesquisa Albert Einstein, v. 10, n. 2, p. 145-150, 2012.
10.1590/S1679-45082012000200006
S1679-45082012000200006.pdf
1679-4508
S1679-45082012000200006
http://repositorio.unifesp.br/handle/11600/7113
url http://dx.doi.org/10.1590/S1679-45082012000200006
http://repositorio.unifesp.br/handle/11600/7113
identifier_str_mv Einstein (São Paulo). Instituto Israelita de Ensino e Pesquisa Albert Einstein, v. 10, n. 2, p. 145-150, 2012.
10.1590/S1679-45082012000200006
S1679-45082012000200006.pdf
1679-4508
S1679-45082012000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Einstein (São Paulo)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 145-150
application/pdf
dc.publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
publisher.none.fl_str_mv Instituto Israelita de Ensino e Pesquisa Albert Einstein
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268296608874496

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