Efeitos do tamoxifeno e dos estrogênios conjugados no epitélio mamário de ratas em estro permanente

• Autor(a) principal: Silva, Benedito Borges da [UNIFESP]
• Data de Publicação: 2000
• Outros Autores: Gebrim, Luiz Henrique [UNIFESP], Simões, Manuel de Jesus [UNIFESP], Baracat, Edmund Chada [UNIFESP], Lima, Geraldo Rodrigues de [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0100-72032000000100006; http://repositorio.unifesp.br/handle/11600/915
• topic: Normal breast; Hormonal replacement therapy; Antiestrogens; Mama normal; Terapia de reposição hormonal; Antiestrogênios

Purpose: to evaluate the morphologic and morphometric alterations produced by tamoxifen and conjugated estrogens in the mammary epithelium of rats in persistent estrus. Methods: thirty-three adult female rats in persistent estrus induced with 1.25 mg testosterone propionate were divided at random into three groups: GI -- which received only water, control group (n = 12); GII -- treated with 500 mug tamoxifen daily (n = 10); GIII -- treated with 30 mug conjugated estrogens per day (n = 11). The first inguinal-abdominal pair of mammary glands of the animals was extirpated and processed for morphologic and morphometric study. Data were analyzed statistically by the Kruskal-Wallis rank analysis of variance (p < 0.05). Results: the morphologic study revealed signs of epithelial atrophy and the morphometric study showed a statistically significant reduction in the mean number of ducts and alveoli in groups II (10.1 and 1.9, respectively) and III (11.1 and 3.5, respectively) compared to group I (25.0 and 6.6, respectively). There was no significant difference between groups II and III. Conclusions: the results of this study indicate that tamoxifen as well as conjugated estrogens at the tested doses produced mammary epithelial atrophy in rats in persistent estrus.