Association between peripheral arterial disease and creactive protein in the japanese-brazilian population

• Autor(a) principal: Garofolo, Luciana [UNIFESP]
• Data de Publicação: 2014
• Outros Autores: Ferreira, Sandra Roberta Gouvea [UNIFESP], Miranda Junior, Fausto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0100-69912014000300006; http://repositorio.unifesp.br/handle/11600/8407
• topic: Peripheral arterial disease; C-reactive protein; Atherosclerosis; Homocysteine; Doença arterial periférica; Proteína C-reativa; Aterosclerose; Homocisteina

OBJECTIVE:To evaluate the relationship between peripheral arterial disease and elevated levels of C-reactive protein in the Japanese-Brazilian population of high cardiovascular risk.METHODS:We conducted a cross-sectional study derived from a population-based study on the prevalence of diabetes and associated diseases in the Japanese-Brazilian population. One thousand, three hundred and thirty individuals aged e 30 underwent clinical and laboratory examination, including measurement of ultrasensitive C-reactive protein. The diagnosis of peripheral arterial disease was performed by calculating the ankle-brachial index. We considered with peripheral arterial disease patients who had ankle-brachial index d 0.9. After applying the exclusion criteria, 1,038 subjects completed the study.RESULTS:The mean age of the population was 56.8 years; 46% were male. The prevalence of peripheral arterial disease was 21%, with no difference between genders. Data analysis showed no association between peripheral arterial disease and ultrasensitive C-reactive protein. Patients with ankle-brachial index d 0.70 showed higher values of ultrasensitive C-reactive protein and worse cardiometabolic profile. We found a positive independent association of peripheral arterial disease with hypertension and smoking.CONCLUSION:The association between low levels of ankle-brachial index and elevated levels of ultrasensitive C-reactive protein may suggest a relationship of gravity, aiding in the mapping of high-risk patients.