Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts

Detalhes bibliográficos
Autor(a) principal: Safatle, Angélica de Mendonça Vaz
Data de Publicação: 2010
Outros Autores: Hvenegaard, Ana Paula, Otsuki, Denise, Martins, Terezinha Luiza, Kahvegian, Márcia, Berezovsky, Adriana [UNIFESP], Salomão, Solange Rios [UNIFESP], Barros, Paulo Sergio de Moraes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-736X2010001200012
http://repositorio.unifesp.br/handle/11600/6102
Resumo: Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.
id UFSP_b8a2aabcf4de088ee119a5bc91c6e11b
oai_identifier_str oai:repositorio.unifesp.br/:11600/6102
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataractsEstudo comparativo do eletrorretinograma de campo total em cães diabéticos e não diabéticos com catarataElectroretinogramdogscataractsdiabetes mellitusdiabetic retinopathyretinaEletrorretinogramacãocataratadiabetes mellitusretinopatia diabéticaretinaBeing the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.Catarata madura e hipermadura, alteração frequentemente observada em cães, impossibilita a visibilização do fundo do olho e provável diagnóstico de degenerações retinianas. Objetivou-se comparar as respostas retiniana de cães diabéticos e não diabéticos, ambos portadores de catarata madura ou hipermadura, com auxílio do eletrorretinograma de campo total, utilizando o protocolo da International Society for Clinical Electrophysiology of Vision. Sessenta e seis cães, com idades variando entre 6 a 15 anos de idade foram divididos em dois grupos: (1) CG, cães não diabéticos com catarata madura ou hipermadura e (2) DG, cães diabéticos com catarata madura ou hipermadura. Mensurou-se amplitude pico a pico (microvolts) e tempo de culminação da onda-b (milisegundos) para as cinco respostas do ERG (resposta de bastonetes, máxima resposta, potencial oscilatório, resposta de cones e flicker a 30Hz). Avaliando-se as respostas obtidas com o exame, o grupo de cães diabéticos apresentou menor amplitude e maior tempo de culminação da onda-b em todas as respostas. O aumento do tempo de culminação da onda-b em DG foi estatisticamente significante (p<0.05) no flicker a 30 Hz (24.0ms versus 22.4ms). ERG de campo total é capaz de registrar alterações em respostas sensíveis como o tempo de culminação da onda-b do flicker, podendo ser útil para investigar retinopatias em cães diabéticos.Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de CirurgiaUSP Faculdade de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Safatle, Angélica de Mendonça VazHvenegaard, Ana PaulaOtsuki, DeniseMartins, Terezinha LuizaKahvegian, MárciaBerezovsky, Adriana [UNIFESP]Salomão, Solange Rios [UNIFESP]Barros, Paulo Sergio de Moraes2015-06-14T13:42:03Z2015-06-14T13:42:03Z2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1071-1076application/pdfhttp://dx.doi.org/10.1590/S0100-736X2010001200012SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 201010.1590/S0100-736X2010001200012S0100-736X2010001200012.pdf0100-736XS0100-736X2010001200012http://repositorio.unifesp.br/handle/11600/6102WOS:000286963600012engPesquisa Veterinária Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T16:55:31Zoai:repositorio.unifesp.br/:11600/6102Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T16:55:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
Estudo comparativo do eletrorretinograma de campo total em cães diabéticos e não diabéticos com catarata
title Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
spellingShingle Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
Safatle, Angélica de Mendonça Vaz
Electroretinogram
dogs
cataracts
diabetes mellitus
diabetic retinopathy
retina
Eletrorretinograma
cão
catarata
diabetes mellitus
retinopatia diabética
retina
title_short Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
title_full Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
title_fullStr Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
title_full_unstemmed Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
title_sort Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
author Safatle, Angélica de Mendonça Vaz
author_facet Safatle, Angélica de Mendonça Vaz
Hvenegaard, Ana Paula
Otsuki, Denise
Martins, Terezinha Luiza
Kahvegian, Márcia
Berezovsky, Adriana [UNIFESP]
Salomão, Solange Rios [UNIFESP]
Barros, Paulo Sergio de Moraes
author_role author
author2 Hvenegaard, Ana Paula
Otsuki, Denise
Martins, Terezinha Luiza
Kahvegian, Márcia
Berezovsky, Adriana [UNIFESP]
Salomão, Solange Rios [UNIFESP]
Barros, Paulo Sergio de Moraes
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Safatle, Angélica de Mendonça Vaz
Hvenegaard, Ana Paula
Otsuki, Denise
Martins, Terezinha Luiza
Kahvegian, Márcia
Berezovsky, Adriana [UNIFESP]
Salomão, Solange Rios [UNIFESP]
Barros, Paulo Sergio de Moraes
dc.subject.por.fl_str_mv Electroretinogram
dogs
cataracts
diabetes mellitus
diabetic retinopathy
retina
Eletrorretinograma
cão
catarata
diabetes mellitus
retinopatia diabética
retina
topic Electroretinogram
dogs
cataracts
diabetes mellitus
diabetic retinopathy
retina
Eletrorretinograma
cão
catarata
diabetes mellitus
retinopatia diabética
retina
description Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
2015-06-14T13:42:03Z
2015-06-14T13:42:03Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-736X2010001200012
SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 2010
10.1590/S0100-736X2010001200012
S0100-736X2010001200012.pdf
0100-736X
S0100-736X2010001200012
http://repositorio.unifesp.br/handle/11600/6102
WOS:000286963600012
url http://dx.doi.org/10.1590/S0100-736X2010001200012
http://repositorio.unifesp.br/handle/11600/6102
identifier_str_mv SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 2010
10.1590/S0100-736X2010001200012
S0100-736X2010001200012.pdf
0100-736X
S0100-736X2010001200012
WOS:000286963600012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Veterinária Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1071-1076
application/pdf
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268373856419840