Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-736X2010001200012 http://repositorio.unifesp.br/handle/11600/6102 |
Resumo: | Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs. |
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Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataractsEstudo comparativo do eletrorretinograma de campo total em cães diabéticos e não diabéticos com catarataElectroretinogramdogscataractsdiabetes mellitusdiabetic retinopathyretinaEletrorretinogramacãocataratadiabetes mellitusretinopatia diabéticaretinaBeing the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.Catarata madura e hipermadura, alteração frequentemente observada em cães, impossibilita a visibilização do fundo do olho e provável diagnóstico de degenerações retinianas. Objetivou-se comparar as respostas retiniana de cães diabéticos e não diabéticos, ambos portadores de catarata madura ou hipermadura, com auxílio do eletrorretinograma de campo total, utilizando o protocolo da International Society for Clinical Electrophysiology of Vision. Sessenta e seis cães, com idades variando entre 6 a 15 anos de idade foram divididos em dois grupos: (1) CG, cães não diabéticos com catarata madura ou hipermadura e (2) DG, cães diabéticos com catarata madura ou hipermadura. Mensurou-se amplitude pico a pico (microvolts) e tempo de culminação da onda-b (milisegundos) para as cinco respostas do ERG (resposta de bastonetes, máxima resposta, potencial oscilatório, resposta de cones e flicker a 30Hz). Avaliando-se as respostas obtidas com o exame, o grupo de cães diabéticos apresentou menor amplitude e maior tempo de culminação da onda-b em todas as respostas. O aumento do tempo de culminação da onda-b em DG foi estatisticamente significante (p<0.05) no flicker a 30 Hz (24.0ms versus 22.4ms). ERG de campo total é capaz de registrar alterações em respostas sensíveis como o tempo de culminação da onda-b do flicker, podendo ser útil para investigar retinopatias em cães diabéticos.Universidade de São Paulo Faculdade de Medicina Veterinária e Zootecnia Departamento de CirurgiaUSP Faculdade de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Safatle, Angélica de Mendonça VazHvenegaard, Ana PaulaOtsuki, DeniseMartins, Terezinha LuizaKahvegian, MárciaBerezovsky, Adriana [UNIFESP]Salomão, Solange Rios [UNIFESP]Barros, Paulo Sergio de Moraes2015-06-14T13:42:03Z2015-06-14T13:42:03Z2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1071-1076application/pdfhttp://dx.doi.org/10.1590/S0100-736X2010001200012SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 201010.1590/S0100-736X2010001200012S0100-736X2010001200012.pdf0100-736XS0100-736X2010001200012http://repositorio.unifesp.br/handle/11600/6102WOS:000286963600012engPesquisa Veterinária Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T16:55:31Zoai:repositorio.unifesp.br/:11600/6102Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T16:55:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts Estudo comparativo do eletrorretinograma de campo total em cães diabéticos e não diabéticos com catarata |
title |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
spellingShingle |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts Safatle, Angélica de Mendonça Vaz Electroretinogram dogs cataracts diabetes mellitus diabetic retinopathy retina Eletrorretinograma cão catarata diabetes mellitus retinopatia diabética retina |
title_short |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
title_full |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
title_fullStr |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
title_full_unstemmed |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
title_sort |
Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts |
author |
Safatle, Angélica de Mendonça Vaz |
author_facet |
Safatle, Angélica de Mendonça Vaz Hvenegaard, Ana Paula Otsuki, Denise Martins, Terezinha Luiza Kahvegian, Márcia Berezovsky, Adriana [UNIFESP] Salomão, Solange Rios [UNIFESP] Barros, Paulo Sergio de Moraes |
author_role |
author |
author2 |
Hvenegaard, Ana Paula Otsuki, Denise Martins, Terezinha Luiza Kahvegian, Márcia Berezovsky, Adriana [UNIFESP] Salomão, Solange Rios [UNIFESP] Barros, Paulo Sergio de Moraes |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Safatle, Angélica de Mendonça Vaz Hvenegaard, Ana Paula Otsuki, Denise Martins, Terezinha Luiza Kahvegian, Márcia Berezovsky, Adriana [UNIFESP] Salomão, Solange Rios [UNIFESP] Barros, Paulo Sergio de Moraes |
dc.subject.por.fl_str_mv |
Electroretinogram dogs cataracts diabetes mellitus diabetic retinopathy retina Eletrorretinograma cão catarata diabetes mellitus retinopatia diabética retina |
topic |
Electroretinogram dogs cataracts diabetes mellitus diabetic retinopathy retina Eletrorretinograma cão catarata diabetes mellitus retinopatia diabética retina |
description |
Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2015-06-14T13:42:03Z 2015-06-14T13:42:03Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-736X2010001200012 SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 2010 10.1590/S0100-736X2010001200012 S0100-736X2010001200012.pdf 0100-736X S0100-736X2010001200012 http://repositorio.unifesp.br/handle/11600/6102 WOS:000286963600012 |
url |
http://dx.doi.org/10.1590/S0100-736X2010001200012 http://repositorio.unifesp.br/handle/11600/6102 |
identifier_str_mv |
SAFATLE, Angélica de Mendonça Vaz. et al . Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts. Pesq. Vet. Bras., Rio de Janeiro , v. 30, n. 12, p. 1071-1076, dez. 2010 10.1590/S0100-736X2010001200012 S0100-736X2010001200012.pdf 0100-736X S0100-736X2010001200012 WOS:000286963600012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinária Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1071-1076 application/pdf |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
publisher.none.fl_str_mv |
Colégio Brasileiro de Patologia Animal - CBPAEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268373856419840 |