Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification

Detalhes bibliográficos
Autor(a) principal: Tanaka, Carlos Itio [UNIFESP]
Data de Publicação: 1997
Outros Autores: Gebrim, Luiz Henrique [UNIFESP], Lima, Geraldo Rodrigues de [UNIFESP], Simões, Manuel de Jesus [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000qkpd
DOI: 10.1590/S1516-31801997000200004
Texto Completo: http://dx.doi.org/10.1590/S1516-31801997000200004
http://repositorio.unifesp.br/handle/11600/481
Resumo: Tamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transformation has not been fully elucidated. This prospective, randomized study assessed the estrogen activity of tamoxifen on the mammary gland epithelium of premenopausal patients using a quantitative analysis of mammary epithelium lysosomes identified by the cytochemical technique of GOMORI for acid phosphatase and by light microscopy. Tamoxifen significantly increased the number of lysosomes only during the secretory phase of the menstrual cycle. We concluded that the early effect of the drug on normal mammary tissue is synergistic with the effect of estrogen during the premenopausal period.
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spelling Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantificationTamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transformation has not been fully elucidated. This prospective, randomized study assessed the estrogen activity of tamoxifen on the mammary gland epithelium of premenopausal patients using a quantitative analysis of mammary epithelium lysosomes identified by the cytochemical technique of GOMORI for acid phosphatase and by light microscopy. Tamoxifen significantly increased the number of lysosomes only during the secretory phase of the menstrual cycle. We concluded that the early effect of the drug on normal mammary tissue is synergistic with the effect of estrogen during the premenopausal period.INTRODUÇÃO: O tamoxifeno é uma droga antiestrogênica largamente utilizada no tratamento hormonal adjuvante do carcinoma mamário. Atualmente, vem sendo proposto a sua utilização na profilaxia primária desta doença. Trata-se de uma droga de poucos efeitos colaterais que ainda não tem estabelecido a exata forma de ação, em tecido mamário que não sofreu transformação neoplásica. OBJETIVO: Avaliar a atividade estrogênica do tamoxifeno no epitélio da glândula mamária de pacientes na pré-menopausa. TIPO DE ESTUDO: Prospectivo - randômico. METODOLOGIA: Análise quantitativa dos Iisossomos do epitélio mamário identificados peia técnica citoquímica de GOMORI para a fosfatase ácida e microscopia de luz. RESULTADOS: Observou-se que o tamoxifeno aumentou de forma significante, o número de lisossomos somente na fase secretora do ciclo menstrual. CONCLUSÃO: concluiu-se que o efeito inicial da droga em tecido mamário normal, na pré-menopausa, tem efeito sinérgico ao estrogênio.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of Gynecology and ObstetricsUNIFESP, EPM, Department of Gynecology and ObstetricsSciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)Tanaka, Carlos Itio [UNIFESP]Gebrim, Luiz Henrique [UNIFESP]Lima, Geraldo Rodrigues de [UNIFESP]Simões, Manuel de Jesus [UNIFESP]2015-06-14T13:24:35Z2015-06-14T13:24:35Z1997-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1390-1394application/pdfhttp://dx.doi.org/10.1590/S1516-31801997000200004São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 115, n. 2, p. 1390-1394, 1997.10.1590/S1516-31801997000200004S1516-31801997000200004.pdf1516-3180S1516-31801997000200004http://repositorio.unifesp.br/handle/11600/481ark:/48912/001300000qkpdengSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T06:33:06Zoai:repositorio.unifesp.br/:11600/481Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:31:37.636202Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
title Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
spellingShingle Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
Tanaka, Carlos Itio [UNIFESP]
Tanaka, Carlos Itio [UNIFESP]
title_short Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
title_full Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
title_fullStr Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
title_full_unstemmed Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
title_sort Study of the action of tamoxifen on the mammary gland epithelium of premenopausal patients by lysosome quantification
author Tanaka, Carlos Itio [UNIFESP]
author_facet Tanaka, Carlos Itio [UNIFESP]
Tanaka, Carlos Itio [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
Lima, Geraldo Rodrigues de [UNIFESP]
Simões, Manuel de Jesus [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
Lima, Geraldo Rodrigues de [UNIFESP]
Simões, Manuel de Jesus [UNIFESP]
author_role author
author2 Gebrim, Luiz Henrique [UNIFESP]
Lima, Geraldo Rodrigues de [UNIFESP]
Simões, Manuel de Jesus [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Tanaka, Carlos Itio [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
Lima, Geraldo Rodrigues de [UNIFESP]
Simões, Manuel de Jesus [UNIFESP]
description Tamoxifen is an antiestrogen drug widely utilized for the adjuvant hormonal treatment of breast carcinoma. Its use in the primary prophylaxis of this disease is currently being proposed. Although the drug has few side effects, its precise action on breast tissue that has not undergone neoplastic transformation has not been fully elucidated. This prospective, randomized study assessed the estrogen activity of tamoxifen on the mammary gland epithelium of premenopausal patients using a quantitative analysis of mammary epithelium lysosomes identified by the cytochemical technique of GOMORI for acid phosphatase and by light microscopy. Tamoxifen significantly increased the number of lysosomes only during the secretory phase of the menstrual cycle. We concluded that the early effect of the drug on normal mammary tissue is synergistic with the effect of estrogen during the premenopausal period.
publishDate 1997
dc.date.none.fl_str_mv 1997-04-01
2015-06-14T13:24:35Z
2015-06-14T13:24:35Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-31801997000200004
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 115, n. 2, p. 1390-1394, 1997.
10.1590/S1516-31801997000200004
S1516-31801997000200004.pdf
1516-3180
S1516-31801997000200004
http://repositorio.unifesp.br/handle/11600/481
dc.identifier.dark.fl_str_mv ark:/48912/001300000qkpd
url http://dx.doi.org/10.1590/S1516-31801997000200004
http://repositorio.unifesp.br/handle/11600/481
identifier_str_mv São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 115, n. 2, p. 1390-1394, 1997.
10.1590/S1516-31801997000200004
S1516-31801997000200004.pdf
1516-3180
S1516-31801997000200004
ark:/48912/001300000qkpd
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv São Paulo Medical Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1390-1394
application/pdf
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822219207224328192
dc.identifier.doi.none.fl_str_mv 10.1590/S1516-31801997000200004

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