Peripheral chemokine levels in women with recurrent major depression with suicidal ideation

Detalhes bibliográficos
Autor(a) principal: Grassi-Oliveira, Rodrigo
Data de Publicação: 2012
Outros Autores: Brietzke, Elisa [UNIFESP], Teixeira, Antonio Lúcio [UNIFESP], Pezzi, Júlio Carlos, Zanini, Márcio [UNIFESP], Lopes, Rodrigo Pestana, Bauer, Moisés Evandro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1516-44462012000100013
http://repositorio.unifesp.br/handle/11600/6991
Resumo: OBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.
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spelling Peripheral chemokine levels in women with recurrent major depression with suicidal ideationNíveis periféricos de quimiocina em mulheres com depressão maior com ideação suicidaSuicideSuicidal IdeationChemokinesCytokinesMajor Depressive DisorderMood DisordersInflammationImmunitySuicídioIdeação suicidaQuimiocinasCitocinasTranstorno Depressivo MaiorTranstornos do HumorInflamaçãoImunidadeOBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.OBJETIVO: Comparar os níveis séricos de MCP-1/CCL2, RANTES/CCL5 e Eotaxin/CCL11 entre pacientes do sexo feminino com transtorno depressivo maior (TDM) recorrente e controles saudáveis, verificando se há diferença nos níveis desses mediadores entre os indivíduos com ou sem ideação suicida. MÉTODOS: Trinta pacientes do sexo feminino com TDM recorrente foram divididas em dois grupos de acordo com a presença ou ausência de ideação suicida. Esses grupos foram comparados com 16 controles saudáveis. Os níveis séricos de MCP-1/CCL2, RANTES/CCL5 e Eotaxin/CCL11 foram determinados. A gravidade da depressão foi avaliada usando o Beck Depression Inventory (BDI) e a ideação suicida foi avaliada usando o SCID-I e o BDI. RESULTADOS: As pacientes com TDM recorrente e os controles saudáveis não diferiram em idade, status socioeconômico e educação. Todas as pacientes relataram altas pontuações no BDI (média, SD, n; 29,75, 10,55, 28). A análise de covariância multivariada ajustada para idade e de IMC mostrou que as pacientes com TDM e ideação suicida apresentaram níveis mais baixos de MCP-1/CCL2 e RANTES/CCL5 (p < 0,001) e níveis mais elevados de Eotaxin/CCL11 (p = 0,04) em comparação com os controles saudáveis. Essas diferenças permaneceram significantes após o ajuste para gravidade da depressão. CONCLUSÃO: Os resultados deste estudo indicaram que a presença de TDM recorrente com ideação suicida está associada a diferenças nas quimiocinas inflamatórias na comparação com os indivíduos sem ideação suicida.Pontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research GroupUniversidade Federal de São Paulo (UNIFESP) Program of Interventions in Individuals at Risk Mental StatesUniversidade Federal Minas Gerais School of Medicine Department of Internal MedicineUniversidade Federal de Ciências da Saúde de Porto Alegre Post-Graduate Program in Health SciencesPontifícia Universidade Católica Institute of Biomedical Research and Faculty of BiosciencesUNIFESP, Program of Interventions in Individuals at Risk Mental StatesSciELOAssociação Brasileira de Psiquiatria - ABPPontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research GroupUniversidade Federal de São Paulo (UNIFESP)Universidade Federal Minas Gerais School of Medicine Department of Internal MedicineUniversidade Federal de Ciências da Saúde de Porto Alegre Post-Graduate Program in Health SciencesPontifícia Universidade Católica Institute of Biomedical Research and Faculty of BiosciencesGrassi-Oliveira, RodrigoBrietzke, Elisa [UNIFESP]Teixeira, Antonio Lúcio [UNIFESP]Pezzi, Júlio CarlosZanini, Márcio [UNIFESP]Lopes, Rodrigo PestanaBauer, Moisés Evandro2015-06-14T13:43:38Z2015-06-14T13:43:38Z2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion71-75application/pdfhttp://dx.doi.org/10.1590/S1516-44462012000100013GRASSI-OLIVEIRA, Rodrigo et al . Peripheral chemokine levels in women with recurrent major depression with suicidal ideation. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 1, p. 71-75, mar. 201210.1590/S1516-44462012000100013S1516-44462012000100013.pdf1516-4446S1516-44462012000100013http://repositorio.unifesp.br/handle/11600/6991WOS:000301120200013engRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T07:43:07Zoai:repositorio.unifesp.br/:11600/6991Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T07:43:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
Níveis periféricos de quimiocina em mulheres com depressão maior com ideação suicida
title Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
spellingShingle Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
Grassi-Oliveira, Rodrigo
Suicide
Suicidal Ideation
Chemokines
Cytokines
Major Depressive Disorder
Mood Disorders
Inflammation
Immunity
Suicídio
Ideação suicida
Quimiocinas
Citocinas
Transtorno Depressivo Maior
Transtornos do Humor
Inflamação
Imunidade
title_short Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
title_full Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
title_fullStr Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
title_full_unstemmed Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
title_sort Peripheral chemokine levels in women with recurrent major depression with suicidal ideation
author Grassi-Oliveira, Rodrigo
author_facet Grassi-Oliveira, Rodrigo
Brietzke, Elisa [UNIFESP]
Teixeira, Antonio Lúcio [UNIFESP]
Pezzi, Júlio Carlos
Zanini, Márcio [UNIFESP]
Lopes, Rodrigo Pestana
Bauer, Moisés Evandro
author_role author
author2 Brietzke, Elisa [UNIFESP]
Teixeira, Antonio Lúcio [UNIFESP]
Pezzi, Júlio Carlos
Zanini, Márcio [UNIFESP]
Lopes, Rodrigo Pestana
Bauer, Moisés Evandro
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Pontifícia Universidade Católica Post-Graduate Program in Psychology Developmental Cognitive Neuroscience Research Group
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal Minas Gerais School of Medicine Department of Internal Medicine
Universidade Federal de Ciências da Saúde de Porto Alegre Post-Graduate Program in Health Sciences
Pontifícia Universidade Católica Institute of Biomedical Research and Faculty of Biosciences
dc.contributor.author.fl_str_mv Grassi-Oliveira, Rodrigo
Brietzke, Elisa [UNIFESP]
Teixeira, Antonio Lúcio [UNIFESP]
Pezzi, Júlio Carlos
Zanini, Márcio [UNIFESP]
Lopes, Rodrigo Pestana
Bauer, Moisés Evandro
dc.subject.por.fl_str_mv Suicide
Suicidal Ideation
Chemokines
Cytokines
Major Depressive Disorder
Mood Disorders
Inflammation
Immunity
Suicídio
Ideação suicida
Quimiocinas
Citocinas
Transtorno Depressivo Maior
Transtornos do Humor
Inflamação
Imunidade
topic Suicide
Suicidal Ideation
Chemokines
Cytokines
Major Depressive Disorder
Mood Disorders
Inflammation
Immunity
Suicídio
Ideação suicida
Quimiocinas
Citocinas
Transtorno Depressivo Maior
Transtornos do Humor
Inflamação
Imunidade
description OBJECTIVE: To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation. METHODS: Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI. RESULTS: Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity. CONCLUSION: The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
2015-06-14T13:43:38Z
2015-06-14T13:43:38Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-44462012000100013
GRASSI-OLIVEIRA, Rodrigo et al . Peripheral chemokine levels in women with recurrent major depression with suicidal ideation. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 1, p. 71-75, mar. 2012
10.1590/S1516-44462012000100013
S1516-44462012000100013.pdf
1516-4446
S1516-44462012000100013
http://repositorio.unifesp.br/handle/11600/6991
WOS:000301120200013
url http://dx.doi.org/10.1590/S1516-44462012000100013
http://repositorio.unifesp.br/handle/11600/6991
identifier_str_mv GRASSI-OLIVEIRA, Rodrigo et al . Peripheral chemokine levels in women with recurrent major depression with suicidal ideation. Rev. Bras. Psiquiatr., São Paulo , v. 34, n. 1, p. 71-75, mar. 2012
10.1590/S1516-44462012000100013
S1516-44462012000100013.pdf
1516-4446
S1516-44462012000100013
WOS:000301120200013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 71-75
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Psiquiatria - ABP
publisher.none.fl_str_mv Associação Brasileira de Psiquiatria - ABP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268423669022720

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